Results 91 to 100 of about 785,223 (333)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Heterogeneity of variance and genetic parameters for milk production in cattle, using Bayesian inference. [PDF]

PLoS One, 2023
Júnior RNCC, Fernandes LDS, do Carmo Panetto JC, Barbosa da Silva MVG, de Araújo CV, Maciel E Silva AG, Felipe Marques JR, Silva WCD, de Araújo SI, Castro SRS, Silva LKX, Castro SV, Júnior JBL.   +12 more
europepmc   +1 more source

Individual Microscopic Results Of Bottleneck Experiments

, 2016
This contribution provides microscopic experimental study of pedestrian motion in front of the bottleneck, explains the high variance of individual travel time by the statistical analysis of trajectories.
B Steffen, D Duives, J Zhang, M Bukáček   +3 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Contributions of Maternal Age Heterogeneity to Variance in Lifetime Reproductive Output. [PDF]

Am Nat, 2022
van Daalen SF, Hernández CM, Caswell H, Neubert MG, Gribble KE.   +4 more
europepmc   +1 more source

The Voyage of the Beagle in Innovation Systems Land. Explorations on Sectors, Innovation, Heterogeneity and Selection [PDF]

The aim of the paper is to assess heterogeneity of the innovation process. Using exploratory factor analysis on micro data from the third Community Innovation Survey in 13 countries, we identify four factors that that can be interpreted as research, user,
Bart Verspagen, Martin Srholec
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Heritability of physical activity traits in Brazilian families: the Baependi Heart Study

BMC Medical Genetics, 2011
Background It is commonly recognized that physical activity has familial aggregation; however, the genetic influences on physical activity phenotypes are not well characterized.
Horimoto Andréa RVR, Giolo Suely R, Oliveira Camila M, Alvim Rafael O, Soler Júlia P, de Andrade Mariza, Krieger José E, Pereira Alexandre C   +7 more
doaj   +1 more source

Block Analysis for the Calculation of Dynamic and Static Length Scales in Glass-Forming Liquids

, 2017
We present {\it block analysis}, an efficient method to perform finite-size scaling for obtaining the length scale of dynamic heterogeneity and the point-to-set length scale for generic glass-forming liquids.
Chakrabarty, Saurish, Dasgupta, Chandan, Karmakar, Smarajit, Tah, Indrajit   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source