Results 131 to 140 of about 785,223 (333)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
SUBSET: Best Subsets using Information Criteria [PDF]
SUBSET, written in the matrix language Gauss, is a program that identifies optimal subsets of means or proportions based on independent groups. All possible configurations of ordered subsets of groups are identified and the best model is selected using ...
C. Mitchell Dayton
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
The Macroeconomic Role of Unemployment Compensation [PDF]
The standard motivation for unemployment compensation is consumption smoothing and most papers in the literature have analyzed trade-offs involving consumption smoothing and moral hazard.
Eran Yashiv, Tomer Blumkin, Yossi Hadar
core
Population structure and variance effective size of red snapper (Lutjanus campechanus) in the northern Gulf of Mexico* [PDF]
, 2006 We assayed allelic variation at 19 nuclear-encoded microsatellites among 1622 Gulf red snapper (Lutjanus campechanus) sampled from the 1995 and 1997 cohorts at each of three offshore localities in the northern Gulf of Mexico (Gulf).
Gold, John R., Saillant, Eric
core
Analyses of Data with Heterogeneous Variance: A Review
Journal of Dairy Science, 1971 Abstract Appropriate analyses are reviewed for comparisons of means and estimation of regression coefficients when variances are not uniform. Approximate t and F-statistics are illustrated for comparisons of two means, k means, multiple comparisons, and two-way classifications. Transformations and weighted regression also are discussed.
openaire +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Ciência Animal Brasileira, 2017 A progeny test representing the milk yield was simulated to evaluate the effect of heterogeneity of environmental variance on genetic evaluation of sires in situations of unequal number of progeny per sire between herds, eliminating, at random, daughters
Claudio Vieira de Araujo +4 more
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