Results 71 to 80 of about 785,223 (333)
How to quantify between-study heterogeneity in single-arm evidence synthesis?—It depends!
Systematic ReviewsBackground Random-effects meta-analysis models account for between-study heterogeneity by estimating and incorporating the heterogeneity variance parameter $${\tau }^{2}$$ τ 2 .
Stefania Iaquinto +4 more
doaj +1 more source
The Cost of Legal Restrictions on Experience Rating [PDF]
, 2020 We investigate the cost of legal restrictions on experience rating in auto and home insurance. The cost is an opportunity cost as experience rating can mitigate the problems associated with unobserved heterogeneity in claim risk, including mispriced ...
Barseghyan, Levon +3 more
core +1 more source
Effective boundary conditions for dense granular flows [PDF]
, 2008 We derive an effective boundary condition for granular flow taking into account the effect of the heterogeneity of the force network on sliding friction dynamics.
A. N. Schofield +6 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Genetic heterogeneity of within-family variance of body weight in Atlantic salmon (Salmo salar)
Genetics Selection Evolution, 2013 Canalization is defined as the stability of a genotype against minor variations in both environment and genetics. Genetic variation in degree of canalization causes heterogeneity of within-family variance. The aims of this study are twofold: (1) quantify
A. Sonesson +2 more
semanticscholar +1 more source
Self-organized Boolean game on networks
, 2005 A model of Boolean game with only one free parameter $p$ that denotes the strength of herd behavior is proposed where each agent acts according to the information obtained from his neighbors in network and those in the minority are rewarded.
B. Bollobás +8 more
core +1 more source
Heterogeneity of (Co)Variance Components for Jersey Type Traits
Journal of Dairy Science, 2001 Heterogeneity of (co)variances for US Jersey linear and final scores was investigated with data from February 2000 USDA genetic evaluations. (Co)variances were estimated from data sets defined by parity, contemporary group size, and mean final score. First-appraisal scores during first or second parity from records that included all traits were studied.
Gengler, Nicolas +4 more
openaire +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source