Results 61 to 70 of about 95,715 (219)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Recent Applications of Focused Ion Beam–Scanning Electron Microscopy in Advanced Packaging

Journal of Manufacturing and Materials Processing
Advanced packaging represents a crucial technological evolution aimed at overcoming limitations posed by Moore’s Law, driving the semiconductor industry from two-dimensional toward three-dimensional integrated structures.
Huan Zhang, Mengmeng Ma, Yuhang Liu, Wenwu Zhang, Chonglei Zhang   +4 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Topological transition of Pancharatnam–Berry phase in a nonlocal twisted bilayer metasurface

Scientific Reports
The Pancharatnam-Berry (PB) phase principle has been extensively utilized in the design of polarization-dependent, ultrathin, phase-gradient metasurfaces, where the PB phase shift is determined by twice the change in orientation angle of individual ...
Yongqing Huang, Yachao Liu, Mingwei Wang, Xiandi Chen, Haoliang Han, Aofei Yu, Guo Ping Wang   +6 more
doaj   +1 more source

A Dual-Polarized Multi-Wideband Ceiling Antenna With Eight-Diagram Shape for 2G/3G/LTE/5G Sub-6 GHz Indoor Applications

IEEE Access
This paper presents a dual-polarized, multi-wideband ceiling antenna with an eight-diagram shape for indoor communication in the 2G/3G/LTE/5G sub-6 GHz frequency range.
Botao Feng, Siyuan Qi, Xiao Ding, Xingxing Yang, Chow-Yen-Desmond Sim   +4 more
doaj   +1 more source

Heterogeneous Agents Situated in Heterogeneous Spaces

Applied Artificial Intelligence, 2002
This paper introduces the Multi-layered Multi-Agent Situated System model (MMASS), a model for Multi-Agent Systems (MAS) situated in an environment. The main feature of the MMASS model is to give an explicit definition of the spatial structure of the environment in which the system of situated agents are acting and interacting.
BANDINI, STEFANIA, MANZONI, SARA LUCIA, SIMONE, CARLA   +2 more
openaire   +3 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Individual Genetic Heterogeneity

Genes, 2022
Genetic variation has been widely covered in literature, however, not from the perspective of an individual in any species. Here, a synthesis of genetic concepts and variations relevant for individual genetic constitution is provided. All the different levels of genetic information and variation are covered, ranging from whether an organism is unmixed ...
openaire   +2 more sources