Results 121 to 130 of about 1,365,709 (331)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Journal of Agricultural SciencesThe second pillar of the European Union’s (EU) Common Agricultural Policy (CAP) aims at supporting rural areas by meeting the economic, environmental and social challenges. To deal with these challenges, countries are faced with the question of selecting
Rosalia Filippini +6 more
doaj +1 more source
THE REPRESENTATIVE CONSUMER IN THE NEOCLASSICAL GROWTH MODEL WITH IDIOSYNCRATIC SHOCKS [PDF]
This paper studies a complete-market version of the neoclassical growth model, where agents face idiosyncratic shocks to earnings. We show that if agents possess identical preferences of either the CRRA or the addilog type, then the heterogeneous-agent ...
Lilia Maliar, Serguei Maliar
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Innovation Diffusion Among Heterogeneous Agents
, 2008 In this paper we apply Agent-Based Modelling (ABM) to capture the complexity of the diffusion process depicted in Medical Innovation, the classic study on diffusion of a new drug Tetracycline by (Coleman, Katz, & Menzel, 1966). Based on our previous model with homogenous social agents, Gammanym (Ratna, Dray, Perez, Grafton, Newth, & Kompas ...
Ratna, Nazmun +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Essays on expectations and the econometrics of asset pricing [PDF]
, 2013 The way in which market participants form expectations affects the dynamic properties of financial asset prices and therefore the appropriateness of different econometric tools used for empirical asset pricing.
Lof, Matthijs
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Open Physics, 2017 Because many networked systems can only be characterized with fractional-order dynamics in complex environments, fractional-order calculus has been studied deeply recently.
Yang Hongyong +4 more
doaj +1 more source
Beyond DSGE Models: Toward an Empirically Based Macroeconomics [PDF]
This paper argues that macro models should be as simple as possible, but not more so. Existing models are “more so” by far. It is time for the science of macro to step beyond representative agent, DSGE models and focus more on alternative heterogeneous ...
Alan Kirman +4 more
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