Results 131 to 140 of about 175,206 (343)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Fighting coal — Effectiveness of coal-replacement programs for residential heating in China: Empirical findings from a household survey [PDF]

, 2020
Household fuel substitution has been a crucial step for controlling air pollution in China, but the performance evaluation of household fuel substitution policies is overlooked.
Feng, W, Khanna, N, Wu, S, Zheng, X
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Chi-squared tests for evaluation and comparison of asset pricing models [PDF]

Using data for the Philippines, I develop and estimate a heterogeneous agent model to analyze the role of monetary policy in a small open economy subject to sizable remittance fluctuations.
Cesare Robotti, Nikolay Gospodinov, Raymond Kan   +2 more
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

A heterogeneous-agent model with district-level constraints: an application to livestock development in Gansu, China [PDF]

This paper develops a heterogeneous-agent model to assess the impacts of removing lucerne growing subsidies, increasing livestock numbers and including district-level equilibrium conditions on optimal farm plans in the Qingyang district of Gansu Province,
Brown, Colin G., Komarek, Adam M., Waldron, Scott A.   +2 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Female - headed households, poverty, and the welfare of children in urban Brazil [PDF]

The authors analyze the characteristics and behavior of households headed by women in urban Brazil and identify some of the consequences for child welfare on the growth of these households. The following was among their findings. First, households headed
Barros, Ricardo, DEC, Fox, Louise, Mendonca, Rosane   +3 more
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Urban-rural equalization of basic public services, fertility behavior and growth

International Review of Economics & Finance
The equalization of basic public services is a central reform priority in China. This study develops a three-period overlapping generations (OLG) model with heterogeneous agents to examine how urban-rural equalization in pension subsidies and public ...
Ning Zhang, Yue Ding
doaj   +1 more source