Results 41 to 50 of about 10,669 (267)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Heterogeneous Database Integration in Biomedicine

Journal of Biomedical Informatics, 2001
The rapid expansion of biomedical knowledge, reduction in computing costs, and spread of internet access have created an ocean of electronic data. The decentralized nature of our scientific community and healthcare system, however, has resulted in a patchwork of diverse, or heterogeneous, database implementations, making access to and aggregation of ...
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Topological transition of Pancharatnam–Berry phase in a nonlocal twisted bilayer metasurface

Scientific Reports
The Pancharatnam-Berry (PB) phase principle has been extensively utilized in the design of polarization-dependent, ultrathin, phase-gradient metasurfaces, where the PB phase shift is determined by twice the change in orientation angle of individual ...
Yongqing Huang, Yachao Liu, Mingwei Wang, Xiandi Chen, Haoliang Han, Aofei Yu, Guo Ping Wang   +6 more
doaj   +1 more source

SAF-PUF: A Strong PUF with Zero-BER, ML-Resilience and Dynamic Key Concealment Enabled by RRAM Stuck-at-Faults

Applied Sciences
Targeting resource-constrained Internet of Things (IoT) devices, this paper proposes Stuck-at-Fault Physical Unclonable Function (SAF-PUF), a lightweight Resistive Random-Access Memory (RRAM)-based PUF that exploits the intrinsic addresses of ...
Qianwu Zhang, Bingyang Zheng, Lin-Sheng Wu, Xin Zhao   +3 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Wafer-scale fabrication of solid-state nanopore array with a novel SpacerX process

Microsystems & Nanoengineering
Solid-state nanopores (SSNPs) have emerged as a transformative platform in nanotechnology and biotechnology, yet their application is limited by the lack of cost-effective, reproducible fabrication technology.
Lihuan Zhao, Jiajun Wang, Lin-Sheng Wu, Xin Zhao   +3 more
doaj   +1 more source

Dual-modal spatiotemporal imaging of ultrafast dynamics in laser-induced periodic surface structures

Light: Advanced Manufacturing
The interactions between ultrafast lasers and materials reveal a range of nonlinear transient phenomena that are crucial in advanced manufacturing.
Qianyi Wei, Jielei Ni, Yuquan Zhang, Yanan Fu, Zhangyu Zhou, Xi Xie, Yixuan Chen, Shuoshuo Zhang, Xiaocong Yuan, Changjun Min   +9 more
doaj   +1 more source