Results 61 to 70 of about 231,021 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dual-branch geometric algebra graph network with pyramid fusion for deformable medical image registration

Journal of King Saud University: Computer and Information Sciences
Deformable medical image registration (DMIR) is a fundamental component in contemporary medical image analysis. Graph Neural Networks (GNNs) offer strong spatial modeling, but deeper, multi-stage GNNs often lead to over-smoothed features across different
Muhammad Anwar, Wenming Cao
doaj   +1 more source

A D-Band Self-Packaged Low Loss Grounded Coplanar Waveguide to Rectangular Waveguide Transition With Silicon-Based Air Cavity-Backed Structure

IEEE Journal of Microwaves
A novel D-band self-packaged silicon-based air cavity-backed transition from grounded coplanar waveguide to air-filled rectangular waveguide was investigated, fabricated, and measured in this work.
Zi-Qi Zhang, Xiao-Long Huang, Liang Zhou, Yin-Shan Huang, Cheng-Rui Zhang   +4 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Quantum lock-in measurement of weak alternating signals

Quantum Frontiers
The detection of weak time-dependent alternating signals in a strongly noisy background is an important problem in physics and a critical task in metrology. Quantum lock-in amplifier can extract alternating signals within extreme noises by using suitable
Min Zhuang, Sijie Chen, Jiahao Huang, Chaohong Lee   +3 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Structureless excitation and manipulation of dynamic holographic plasmonic slides

Nature Communications
Surface plasmons are bound modes at metal–dielectric interfaces and enable a wide range of applications. However, holographic plasmonic fields are usually realized with complex nanostructures, introducing diffraction background and limiting flexibility ...
Yuquan Zhang, Haixiang Ma, Zhendong Ju, Xusheng Chen, Yixuan Chen, Xi Xie, Luping Du, Changjun Min, Xiaocong Yuan   +8 more
doaj   +1 more source

Bandwidth Enhancement of H-Plane MIMO Patch Antennas in Integrated Sensing and Communication Applications

IEEE Open Journal of Antennas and Propagation
In this paper, a low-cost compact decoupled bandwidth enhancement technique is proposed to address the high mutual coupling issue between wideband closely-spaced multiple-input and multiple-out (MIMO) patch antennas.
Lina Ma, Zijian Shao, Jun Lai, Changzhan Gu, Junfa Mao   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source