Results 71 to 80 of about 260,326 (318)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Wafer-scale fabrication of solid-state nanopore array with a novel SpacerX process

Microsystems & Nanoengineering
Solid-state nanopores (SSNPs) have emerged as a transformative platform in nanotechnology and biotechnology, yet their application is limited by the lack of cost-effective, reproducible fabrication technology.
Lihuan Zhao, Jiajun Wang, Lin-Sheng Wu, Xin Zhao   +3 more
doaj   +1 more source

SAF-PUF: A Strong PUF with Zero-BER, ML-Resilience and Dynamic Key Concealment Enabled by RRAM Stuck-at-Faults

Applied Sciences
Targeting resource-constrained Internet of Things (IoT) devices, this paper proposes Stuck-at-Fault Physical Unclonable Function (SAF-PUF), a lightweight Resistive Random-Access Memory (RRAM)-based PUF that exploits the intrinsic addresses of ...
Qianwu Zhang, Bingyang Zheng, Lin-Sheng Wu, Xin Zhao   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Electromigration Reliability of Cu3Sn Microbumps for 3D Heterogeneous Integration

Publisher Copyright: © 2024 IEEE. | openaire: EC/H2020/876659/EU//iRel403D heterogeneous integration (HI) and advanced packaging (AP) technologies require small volume, high-density interconnects for stacking discrete chips for which the reliability of ...
Grosse, Christian, Windemuth, Thilo, Ross, Glenn, Kögel, Michael, Brand, Sebastian, Paulasto-Kröckel, Mervi, Tiwary, Nikhilendu, Vuorinen, Vesa   +7 more
core   +1 more source

Dual-modal spatiotemporal imaging of ultrafast dynamics in laser-induced periodic surface structures

Light: Advanced Manufacturing
The interactions between ultrafast lasers and materials reveal a range of nonlinear transient phenomena that are crucial in advanced manufacturing.
Qianyi Wei, Jielei Ni, Yuquan Zhang, Yanan Fu, Zhangyu Zhou, Xi Xie, Yixuan Chen, Shuoshuo Zhang, Xiaocong Yuan, Changjun Min   +9 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A D-Band Self-Packaged Low Loss Grounded Coplanar Waveguide to Rectangular Waveguide Transition With Silicon-Based Air Cavity-Backed Structure

IEEE Journal of Microwaves
A novel D-band self-packaged silicon-based air cavity-backed transition from grounded coplanar waveguide to air-filled rectangular waveguide was investigated, fabricated, and measured in this work.
Zi-Qi Zhang, Xiao-Long Huang, Liang Zhou, Yin-Shan Huang, Cheng-Rui Zhang   +4 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Dual-branch geometric algebra graph network with pyramid fusion for deformable medical image registration

Journal of King Saud University: Computer and Information Sciences
Deformable medical image registration (DMIR) is a fundamental component in contemporary medical image analysis. Graph Neural Networks (GNNs) offer strong spatial modeling, but deeper, multi-stage GNNs often lead to over-smoothed features across different
Muhammad Anwar, Wenming Cao
doaj   +1 more source