Results 91 to 100 of about 260,326 (318)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

4x25 Gbps polarization diversity silicon photonics receiver with transfer printed III-V photodiodes [PDF]

, 2019
We demonstrate the transfer-printing-based integration of III-V substrate-illuminated p-i-n photodetectors onto a 4-wavelength-channel silicon photonics polarization diversity receiver circuit.
Roelkens, Günther, Corbett, Brian M., Van Thourhout, Dries, Corbett, Brian, Van Gasse, Kasper, Trindade, Antonio José, Muliuk, Grigorij, Van Kerrebrouck, Joris   +7 more
core   +1 more source

Structureless excitation and manipulation of dynamic holographic plasmonic slides

Nature Communications
Surface plasmons are bound modes at metal–dielectric interfaces and enable a wide range of applications. However, holographic plasmonic fields are usually realized with complex nanostructures, introducing diffraction background and limiting flexibility ...
Yuquan Zhang, Haixiang Ma, Zhendong Ju, Xusheng Chen, Yixuan Chen, Xi Xie, Luping Du, Changjun Min, Xiaocong Yuan   +8 more
doaj   +1 more source

A Point Cloud Improvement Method for High-Resolution 4D mmWave Radar Imagery

Remote Sensing
To meet the requirement of autonomous driving development, high-quality point cloud generation of the environment has become the focus of 4D mmWave radar development.
Qingmian Wan, Hongli Peng, Xing Liao, Weihao Li, Kuayue Liu, Junfa Mao   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Intelligent Techniques for the Extraction and Integration of Heterogeneous Information

, 1999
Developing intelligent tools for the integration of information extracted from multiple heterogeneous sources is a challenging issue to effectively exploit the numerous sources available on-line in global information systems.
Bergamaschi Castano, BENEVENTANO, Domenico, M. Vincini, D. Beneventano, S. Bergamaschi, BERGAMASCHI, Sonia, S. Castano, VINCINI, Maurizio   +7 more
core  

Porous nanocomposites with enhanced intrinsic piezoresistive sensitivity for bioinspired multimodal tactile sensors

Microsystems & Nanoengineering
In this work, we propose porous fluororubber/thermoplastic urethane nanocomposites (PFTNs) and explore their intrinsic piezoresistive sensitivity to pressure.
Jianpeng Zhang, Song Wei, Caichao Liu, Chao Shang, Zhaoqiang He, Yu Duan, Zhengchun Peng   +6 more
doaj   +1 more source

Toward Skin-like Sensors: Stretchable Conductive Gels for Triboelectric Applications

Gels
With the rapid development of artificial intelligence and wearable electronics, there is an increasing demand for skin-like, flexible, and self-powered sensors capable of continuously perceiving mechanical stimuli and human motions.
Zejun Shen, Na Li, Jianjing Yi, Xiuru Xu, Xiaoxiao Mo, Ruopeng Wang   +5 more
doaj   +1 more source

All-optical wavelength migration and erasure via nonlinear polarization gating in a TiN/Ti3C2 heterojunction microfiber hybrid device [PDF]

APL Photonics
Conventional all-optical wavelength converters suffer from a fundamental limitation: the residual original signal remains at the output, resulting in spectral inefficiency and potential coherent crosstalk.
Yufeng Song, Wenhai Tan, Zhenhong Wang, Jianhua Ji   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source