Results 51 to 60 of about 321,248 (311)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Shear Correction Factor for Porous Eco-Materials: Mechanical Characterization of a Heterogeneous Medium

Buildings
Classical formulas for the shear correction factor ks, typically derived for homogeneous continua, are unsuitable for porous media exhibiting local density gradients, irregular pore morphologies, and spatially varying stiffness.
Julia Graczyk, Tomasz Gajewski, Tomasz Garbowski   +2 more
doaj   +1 more source

Modeling cell movement in anisotropic and heterogeneous network tissues [PDF]

, 2007
Cell motion and interaction with the extracellular matrix is studied deriving a kinetic model and considering its diffusive limit. The model takes into account of chemotactic and haptotactic effects, and obtains friction as a result of the interactions ...
A. Chauviere, null null, T. Hillen, Preziosi, Luigi, L. Preziosi, Chauviere, A., Hillen, T.   +6 more
core   +1 more source

Heterogeneous Reactions of Epoxides in Acidic Media [PDF]

The Journal of Physical Chemistry A, 2012
Epoxides have recently been identified as important intermediates in the gas phase oxidation of hydrocarbons, and their hydrolysis products have been observed in ambient aerosols. To evaluate the role of epoxides in the formation of secondary organic aerosols (SOA), the kinetics and mechanism of heterogeneous reactions of two model epoxides, isoprene ...
Vinita, Lal, Alexei F, Khalizov, Yun, Lin, Maria D, Galvan, Brian T, Connell, Renyi, Zhang   +5 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

How Environmental Uncertainty Drives Asymmetric Mispricing in China: Dual Channels and Heterogeneous Media Effect

International Journal of Financial Studies
The essay delves into the impact of environmental uncertainty on asymmetric mispricing, utilizing the data from listed firms in China spanning from 2007 to 2023.
Shuya Hu, Shengnian Wang
doaj   +1 more source

On the measurement of solute concentrations in 2-D flow tank experiments [PDF]

, 2007
In this study we describe and compare photometric and resistivity measurement methodologies to determine solute concentrations in porous media flow tank experiments.
E. Meier, Ackerer, P., Gechter, D., D. Gechter, Meier, E., Konz, M., M. Konz, Huggenberger, P., Zechner, E., P. Ackerer, P. Huggenberger, E. Zechner   +11 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Mathematical Treatment of Saturated Macroscopic Flow in Heterogeneous Porous Medium: Evaluating Darcy’s Law

Hydrology, 2019
We present a rigorous mathematical treatment of water flow in saturated heterogeneous porous media based on the classical Navier-Stokes formulation that includes vorticity in a heterogeneous porous media.
R. William Nelson, Gustavious P. Williams   +1 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source