Results 71 to 80 of about 321,248 (311)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Power law singularity of catastrophic rupture in heterogeneous media

, 2009
Catastrophic rupture in heterogeneous media, such as earthquake in crust, has long been a topic of scientific and societal importance. However, there has been no reliable approach to its prediction.
Bai YL(白以龙), Xia MF(夏蒙芬), Lu MF, Ke FJ(柯孚久), Hao SW(郝圣旺), Bai, YL (reprint author), CAS, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.   +5 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Finite Volume Method for Elastic Waves in Heterogeneous, Anisotropic and Fractured Media

ARC Geophysical Research
Numerical modeling of elastic wave propagation in the subsurface requires applicability to heterogeneous, anisotropic and discontinuous media, as well as support of free surface boundary conditions.
Ingrid Kristine Jacobsen, Inga Berre, Jan Martin Nordbotten, Ivar Stefansson   +3 more
doaj   +1 more source

Wavefield Evolution and Arrival Behavior of Elastic Wave Propagation in Two-Dimensional Fractional Brownian Fields

Fractal and Fractional
The fractional Brownian field is often used to reproduce the fractal properties of complex heterogeneous media, which closely represent real-world geological materials.
Shuaifeng Wang, Zixin Zhang
doaj   +1 more source

A mass-conservative control volume-finite element method for solving Richards’ equation in heterogeneous porous media

, 2011
We present a mass-conservative vertex-centred finite volume method for efficiently solving the mixed form of Richards’ equation in heterogeneous porous media.
Ian Turner, Ben Cumming, Moroney, Timothy J., Turner, Ian, Tim Moroney, Cumming, Benjamin   +5 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Linear Boltzmann Equation for Solute Dispersion in Heterogeneous Media Under Non-Ergodic Conditions

ARC Geophysical Research
We study solute dispersion under non-ergodic conditions using a Boltzmann equation for the evolution of the joint distribution of the position and speed of solute particles in steady spatially heterogeneous flow fields.
Marco Dentz, Arash Massoudieh
doaj   +1 more source

1-D Reactive Transport Modelling in Heterogeneous Porous Media

Chemical Engineering Transactions, 2011
preview not available - see full-text PDF article.
O. Saouli, M. Bencheikh Lehocine, A.H. Meniai   +2 more
doaj   +1 more source

Multi-Paradigm Reasoning for Access to Heterogeneous GIS [PDF]

, 2005
Accessing and querying geographical data in a uniform way has become easier in recent years. Emerging standards like WFS turn the web into a geospatial web services enabled place.
Lorenz, Bernhard, Colonna, François-Marie, Bry, François   +2 more
core   +1 more source