Results 61 to 70 of about 1,151,520 (297)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Analysis of Two-Worm Interaction Model in Heterogeneous M2M Network

Information, 2015
With the rapid development of M2M (Machine-to-Machine) networks, the damages caused by malicious worms are getting more and more serious. By considering the influences of the network heterogeneity on worm spreading, we are the first to study the complex ...
Jinhua Ma, Zhide Chen, Jianghua Liu, Rongjun Zheng   +3 more
doaj   +1 more source

Heterogeneous pair approximation for voter models on networks [PDF]

, 2009
For models whose evolution takes place on a network it is often necessary to augment the mean-field approach by considering explicitly the degree dependence of average quantities (heterogeneous mean-field).
Baronchelli A. Pastor-Satorras R., Barrat A., C. Castellano, Castellano C., E. Pugliese, Liggett T. M., Suchecki K., Vazquez F.   +7 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Component Carrier Selection and Beamforming Jointly in LTE-Advanced Heterogeneous Network

Dianxin kexue, 2015
To deal with the interference between macro cell and pico cell, or between pico cell themselves in LTE-Advanced heterogeneous network, joint algorithm of component carrier selection and beamforming was proposed. By shutting down a subset of the component
Rui Fang, Changyin Sun, Guangyue Lu, Longlong Zheng   +3 more
doaj  

A Distributed Interference Alignment Approach Based on Grouping in Heterogeneous Network

IEEE Access, 2018
To effectively mitigate interference and improve the performance, we propose a grouping-based two-stage distributed interference alignment (GTDIA) scheme for a two-layered heterogeneous network (HetNet) in multi-user multiple-input-multiple-output (MIMO)
Cai Qin, Sheng Zeng, Chaowei Wang, Du Pan, Weidong Wang, Yinghai Zhang   +5 more
doaj   +1 more source

ActiveHNE: Active Heterogeneous Network Embedding

, 2019
Heterogeneous network embedding (HNE) is a challenging task due to the diverse node types and/or diverse relationships between nodes. Existing HNE methods are typically unsupervised.
Chen, Xia, Domeniconi, Carlotta, Li, Zhao, Wang, Jun, Yu, Guoxian, Zhang, Xiangliang   +5 more
core   +1 more source

Device-to-device communications in LTE-unlicensed heterogeneous Network [PDF]

, 2016
In this article, we look into how the LTE network can efficiently evolve to cater for new data services by utilizing direct communications between mobile devices and extending the direct transmissions to the unlicensed bands, that is, D2D communications ...
Guo, Weisi, Wang, Siyi, Yuan, Hu
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source