Results 71 to 80 of about 831,955 (292)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
A Multi-Layer Parametric Approach to Maximize the Access Probability of Mobile Networks
IEEE Access, 2016 Next-generation mobile networks (5G) are defined to provide access in the framework of heterogeneous systems where it is crucial to have “always on” and “everywhere connectivity” capabilities. This is of fundamental importance
Mauro Biagi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Shared carrier vertical network transformation algorithm in heterogeneous wireless networks
Tongxin xuebao, 2012 In order to enhance the spectrum efficiency in heterogeneous wireless networks,the idea of dynamic spectrum allocation (DSA) used in cognitive radio was introduced into the heterogeneous wireless networks,the idea of vertical handoff for multi-mode ...
Liang ZHAO +3 more
doaj +2 more sources
Toward Virtualized Optical-Wireless Heterogeneous Networks
IEEE AccessTowards supporting a myriad of new services and applications under highly heterogeneous operating conditions, while dynamically adapting to capacity and quality-of-service (QoS) demands, the sixth generation (6G) communication systems are required to ...
Zoran Vujicic +7 more
doaj +1 more source
IEEE Access, 2018 In this paper, we propose a distributed joint computation offloading and resource allocation optimization (JCORAO) scheme in heterogeneous networks with mobile edge computing.
Jing Zhang +3 more
doaj +1 more source
Meteorological Applications, 2022 The current evolution of numerical weather prediction models, climate applications, warning and decision support systems needs more information at increasingly finer scales.
Lorenzo Silvestri +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source