Results 91 to 100 of about 3,391,346 (320)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A comparison of different machine-learning techniques for the selection of a panel of metabolites allowing early detection of brain tumors

Scientific Reports, 2023
Metabolomics combined with machine learning methods (MLMs), is a powerful tool for searching novel diagnostic panels. This study was intended to use targeted plasma metabolomics and advanced MLMs to develop strategies for diagnosing brain tumors ...
Adrian Godlewski, Marcin Czajkowski, Patrycja Mojsak, Tomasz Pienkowski, Wioleta Gosk, Tomasz Lyson, Zenon Mariak, Joanna Reszec, Marcin Kondraciuk, Karol Kaminski, Marek Kretowski, Marcin Moniuszko, Adam Kretowski, Michal Ciborowski   +13 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Production of Particleboards from Hevea brasiliensis Clones and Castor Oil-based Polyurethane Resin

BioResources, 2015
The economic exploitation of rubber tree (Hevea brasiliensis) usage is primarily directed toward latex extraction. After the productive life of the rubber tree forest, the managed area is harvested for planting reformulation.
Maristela Gava, Sarah David Müzel, Larissa Ribas de Lima, Juliana Cortez Barbosa, José Nivaldo Garcia, Bruno Santos Ferreira, Henrique José Servolo Filho, Marcos Silveira Bernardes, Victor Almeida De Araujo   +8 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology
Ovarian cancer is a heterogeneous gynaecological malignancy characterised by high mortality and an absence of reliable biomarkers for detection. In this study, a CpG‐specific, ARMS‐PCR approach was employed to evaluate the methylation status of six ...
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
doaj   +1 more source

Carbon Emissions and Economic Growth: Homogeneous Causality in Heterogeneous Panels [PDF]

This paper introduces the concept of homogeneous non-causality in heterogeneous panels. This concept is used to examine a panel of data for evidence of a causal relationship between GDP and carbon emissions. The technique is compared to the standard test
David J. Maddison, Katrin Rehdanz
core  

Cutout reinforcements for shear loaded laminate and sandwich composite panels [PDF]

, 2008
This paper presents the numerical and experimental studies of shear loaded laminated and sandwich carbon/epoxy composite panels with cutouts and reinforcements aiming at reducing the cutout stress concentration and increasing the buckling stability of
Guo, Shijun J., Zhou, L., Cheung, C. W.
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

SPICEiST: subcellular RNA pattern enhances cell clustering of imaging-based spatial transcriptomics

Genomics & Informatics
Background Imaging-based spatial transcriptomics (ST) enables the quantification of gene expression at single-cell resolution while preserving spatial context, but its utility is limited by small gene panels and challenges in accurate cell segmentation ...
Sungwoo Bae, Yuchang Seong, Dongjoo Lee, Hongyoon Choi   +3 more
doaj   +1 more source