Results 61 to 70 of about 3,391,346 (320)
Heterogeneous Treatment Effects in Panel Data
CoRRWe address a core problem in causal inference: estimating heterogeneous treatment effects using panel data with general treatment patterns. Many existing methods either do not utilize the potential underlying structure in panel data or have limitations in the allowable treatment patterns.
Retsef Levi +3 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Epigenetics, 2018 Accounting for cellular heterogeneity is essential in neonatal epigenome-wide association studies (EWAS) performed on heterogeneous tissues, such as umbilical cord tissue (CT) or cord blood (CB).
Xinyi Lin +10 more
doaj +1 more source
Tumor mutational burden quantification from targeted gene panels: major advancements and challenges
Journal for ImmunoTherapy of Cancer, 2019 Tumor mutational burden (TMB), the total number of somatic coding mutations in a tumor, is emerging as a promising biomarker for immunotherapy response in cancer patients. TMB can be quantitated by a number of NGS-based sequencing technologies.
Sara Gandini +3 more
doaj +1 more source
Energy performance of buildings made of textile-reinforced concrete (TRC) sandwich panels
Magazine of Civil Engineering, 2022 This research aimed to investigate the energy properties of buildings made of textile-reinforced concrete (TRC) sandwich panels in various humidity-climatic zones. Two configurations of sandwich panel are considered: conventional and advanced.
Vatin Nikolai, Korniyenko Sergey
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
ES Materials and ManufacturingThis study focuses on enhancing the blast resistance of composite panels through the design of heterogeneous, stiffness-varying structures optimized for energy absorption.
Noha M. Hassan +4 more
doaj +1 more source
Fiscal Sustainability in Flow Model: Panel Cointegration Approach for the EU-28 [PDF]
Ovidius University Annals: Economic Sciences Series, 2019 This paper assesses fiscal sustainability in 28 European Union economies in the period 1995- 2018, using panel cointegration analysis for fiscal sustainability testing.
Radmila Dragutinović Mitrović +2 more
doaj
Diagnostic Accuracy of Blood-Based Biomarker Panels: A Systematic Review
Frontiers in Aging Neuroscience, 2022 BackgroundBecause of high prevalence of Alzheimer’s disease (AD) in low- and middle-income countries (LMICs), there is an urgent need for inexpensive and minimally invasive diagnostic tests to detect biomarkers in the earliest and asymptomatic stages of ...
Anette Hardy-Sosa +9 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source