Results 81 to 90 of about 15,814,880 (256)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Incremental Learning for Heterogeneous Structure Segmentation in Brain Tumor MRI. [PDF]

Med Image Comput Comput Assist Interv, 2023
Liu X, Shih HA, Xing F, Santarnecchi E, El Fakhri G, Woo J.   +5 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Synergy of tensile strength and ductility in a novel additively manufactured Al-Mg-Mn-Er-Zr alloy with a trilevel equiaxed heterogeneous structure

Virtual and Physical Prototyping
This study investigates a novel Al-Mg-Mn-Er-Zr alloy with high strength and elongation. The uneven distribution of L12-Al3Er and Al3(Er, Zr) phases in the molten pool structure results in a trilevel equiaxed heterogeneous structure in the alloy.
Jifei Hu, Wu Wei, Shengping Wen, Jianlei Bi, Jieming Gao, Xingkai Hou, Kunyuan Gao, Peng Qi, Tongbo Wang, Xiaorong Zhou, Yuyan Zhai, Xiaocheng Shi, Zuoren Nie   +12 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Construction of a ZnO Heterogeneous Structure Using Co₃O₄ as a Co-Catalyst to Enhance Photoelectrochemical Performance. [PDF]

Materials (Basel), 2023
Markhabayeva AA, Kalkozova ZK, Nemkayeva R, Yerlanuly Y, Anarova AS, Tulegenova MA, Tulegenova AT, Abdullin KA.   +7 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

INFORMATION AND LOGICAL MODELS OF THE DYNAMICS OF SECURITY HETEROSTRUCTURES

Надежность и качество сложных систем
Background. The article is devoted to the current problem of ensuring the security of the individual, society and civilization. Materials and methods. Models of the dynamics of heterostructures, primarily humans, are considered.
Oksana V. Kuznetsova, Vladimir A. Shorin, Valery B. Almametov   +2 more
doaj   +1 more source

Achieving Superior Ductility at High Strain Rate in a 1.5 GPa Ultrahigh-Strength Steel without Obvious Transformation-Induced Plasticity Effect

Metals
The development of ultrahigh-strength steels with good ductility is crucial for improving the crashworthiness of automobiles. In the present work, the mechanical responses and deformation behaviors of 1.5 GPa ultrahigh-strength steel were systematically ...
Yao Lu, Tianxing Ma, Zhiyuan Liang, Li Liu   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source