Results 71 to 80 of about 15,814,880 (256)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

High Specific Strength Eutectic High‐Entropy Alloy: Collaborative Effects of TRIP, TWIP, and Nanoprecipitation

Advanced Science
Eutectic high‐entropy alloys (EHEAs), characterized by their combination of hard and ductile phases, hold broad application prospects in terms of mechanical properties. However, the current performance of these alloys is not satisfactory.
Z. Q. Wang, X. T. Li, Z. J. Zhang, Z. F. Zhang   +3 more
doaj   +1 more source

Achieving superior strength-ductility synergy in CoCrNi medium entropy alloy with a novel bionic brick-mud structure

Materials Research Letters
In recent years, the concept of heterogeneous structure (HGS) strengthening has garnered significant attention due to its superior performance relative to conventional strengthening methods. This study presents a novel bionic brick-mud structure designed
Pengcheng Ma, Jiongxian Li, Jiangjie Liao, Feng Ye, Yu Liu, Hai Huang, Jing Qiu, Mian Chen, Jian Hu   +8 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Customized 3D‐printed heterogeneous porous titanium scaffolds for bone tissue engineering

MedComm – Biomaterials and Applications
Bone defect is a common clinical disease. Due to the uncertainty of trauma or infection areas, customized size features are often required for bone substitutes.
Shiqi Fan, Shilei Li, Yunhong Wu, Haoyuan Lei, Yuxiang Qin, Hongyuan Fan, Yuanhua Lin, Changchun Zhou   +7 more
doaj   +1 more source

Heterogeneous Microstructure Provides a Good Combination of Strength and Ductility in Duplex Stainless Steel

Metals
SAF2507 duplex stainless steel (DSS) is often used as a structural component in ocean-going vessels and marine petroleum exploitation equipment, which require superior mechanical properties.
Jingran Yang, Xingfu Li, Cong Li, Zhuangdi Zhou, Shuwei Quan, Zhuang Kang, Shen Qin, Lele Sun, Bo Gao, Xinkun Zhu   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

In-situ synthesized duplex core–shell heterostructures in hypoeutectic Ni–W medium–heavy alloys: a strategy for ultrahigh strength

Materials Research Letters
This study in-situ synthesized a duplex core–shell heterostructure in hypoeutectic Ni–W alloys, which enhanced yield strength from 637 MPa to 1989 MPa (212% increase) and achieved a substantial strain of 19.6%.
Wannian Wang, Zhanxing Chen, Tengfei Ma, Xiaohong Wang, Gang Qin, Ruirun Chen, Guoxin Cao, Jianxin Dong   +7 more
doaj   +1 more source

Design and synthesis of CeO2 nanowire/MnO2 nanosheet heterogeneous structure for enhanced catalytic properties

, 2017
A novel CeO2 nanowires/MnO2 nanosheets heterogeneous structure was successfully synthesized by a facile hydrothermal method and its carbon monoxide (CO) catalytic properties were studied.
Haiwei Du, Y. Wang, Hamidreza Arandiyan, Adnan Younis, Jason A. Scott, Bo Qu, Tao Wan, Xi Lin, Jianchao Chen, Dewei Chu   +9 more
semanticscholar   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source