Results 71 to 80 of about 1,606,057 (299)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Oregon traffic safety performance plan. Annual report

open access: yes, 1998
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Fiscal year 1998-Vols.

core  

System optimal traffic assignment with departure time choice [PDF]

open access: yes, 2007
This thesis investigates analytical dynamic system optimal assignment with departure time choice in a rigorous and original way. Dynamic system optimal assignment is formulated here as a state-dependent optimal control problem.
Chow, A.H.F., Chow, AHF
core  

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier   +3 more
wiley   +1 more source

Deep transformer-based heterogeneous spatiotemporal graph learning for geographical traffic forecasting

open access: yes
Accurate geographical traffic forecasting plays a critical role in urban transportation planning, traffic management, and geospatial artificial intelligence (GeoAI).
Shi, G, Luo, L, Li, J, Song, Y, Pan, S
core   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch   +5 more
wiley   +1 more source

Traffic Oscillations Mitigation in Vehicle Platoon Using a Car-Following Control Model for Connected and Autonomous Vehicle

open access: yesJournal of Advanced Transportation, 2019
Traffic oscillations often occur in road traffic, they make traffic flow unstable, unsafe and inefficient. Emerging connected and autonomous vehicle (CAV) technologies are potential solutions to mitigating the traffic oscillations for the advantages that
Zhijun Gao   +6 more
doaj   +1 more source

Estimation of PCU’s in Heterogeneous Traffic by Different methods [PDF]

open access: yesE3S Web of Conferences
Transportation gets more intricate when cities get busier. Increased motor vehicles are moving into towns, which means increased traffic jams. The impacts of urbanisation are pervasive and include, but are not limited to, traffic performance, road safety,
Abood Ahmed Salam   +5 more
doaj   +1 more source

Micro-simulation modelling for traffic safety: a review and potential application to heterogeneous traffic environment

open access: yes, 2018
This paper critically reviews micro-simulation modelling applications for traffic safety evaluation with respect to the use of different simulation tools, the application of surrogate safety indicators under different aspects of road environments and ...
Md. Shamsul Hoque   +7 more
core   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno   +19 more
wiley   +1 more source

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