Results 91 to 100 of about 434,960 (396)

Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the Endothelium

Advanced Healthcare Materials, EarlyView.
Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, Arnaud Roussel, Fathia Mami‐Chouaib, Fatima Mechta‐Grigoriou, Gérard Zalcman, Fabrice Soncin, Stéphanie Descroix, Maria Carla Parrini   +16 more
wiley   +1 more source

Heterologous ectoine production in Escherichia coli : By-passing the metabolic bottle-neck [PDF]

, 2008
Peer reviewedPublisher ...
Bestaver, Thorsten, Galinski, Erwin A., Louis, Petra   +2 more
core   +2 more sources

Peptide Display Directed Assembly of Biopolymer Core–Silica Shell Particles

Advanced Healthcare Materials, EarlyView.
Bacterial cells are engineered to produce biopolyester particles displaying peptides mediating growth of silica. Peptide‐coated biopolyester particles are treated with silica precursors and silica shell formation is studied. Transmission electron microscopy shows silica‐coated BPs which are formed after the silicification treatment. Characterization of
Deeptee Chandrashekhar Pande, Frank Sainsbury, Bernd H. A. Rehm   +2 more
wiley   +1 more source

Efficient Protein Expression and Virus-Induced Gene Silencing in Plants Using a Crinivirus-Derived Vector. [PDF]

, 2018
Plant virus-based vectors are valuable tools for recombinant gene expression and functional genomics for both basic and applied research. In this study, Lettuce infectious yellows virus (LIYV) of the genus Crinivirus was engineered into a virus vector ...
Falk, Bryce W, Qiao, Wenjie
core   +3 more sources

Heterologous immunity revisited

Parasitology, 2001
Heterologous immunity, or protection by one invading organism against another across phylogenetic divides, has been recognised for decades. It was initially thought to operate largely through enhancement of phagocytosis, but this explanation became untenable when it was realised it worked extremely well against intraerythrocytic protozoa and killed ...
openaire   +3 more sources

Ancestral Protein‐Based Lighting

Advanced Materials, EarlyView.
The ancestral sequence reconstruction (ASR) method applied to a large dataset of modern fluorescent proteins (FPs) led to a bright ancestral‐like FP suitable for photon down‐conversion in bio‐hybrid light‐emitting diodes (Bio‐HLEDs). Abstract Protein‐optoelectronics is a paradigm toward eco‐designed and sustainable technologies.
Stephanie Willeit, Alexander Mauz, David Gutiérrez‐Armayor, Joseph Arbash, Jesús Agustín Banda‐Vázquez, Sergio Martí, Pedro B. Coto, Rubén D. Costa   +7 more
wiley   +1 more source

Efficacy of the COVID-19 vaccination in patients with asymptomatic or mild illness during the Omicron epidemic in Guangzhou: a multi-centre retrospective cohort study

Annals of Medicine
Background Despite the widespread administration of coronavirus disease 2019 (COVID-19) vaccines, the impact on patients with asymptomatic to mild illness remains unclear.
Yuanda Xu, Xuetao Kong, Weiqing Huang, Zijing Liang, Jinkun Huang, Yimin Li, Nuofu Zhang, Dan Liu, Wenwei Guo, Jiang Mei   +9 more
doaj   +1 more source

Antibody persistence and safety after heterologous boosting with orally aerosolised Ad5-nCoV in individuals primed with two-dose CoronaVac previously: 12-month analyses of a randomized controlled trial

Emerging Microbes and Infections, 2023
Antibody persistence and safety up to 12 months of heterologous orally administered adenovirus type-5 vector-based COVID-19 vaccine (Ad5-nCoV) in individuals who were primed with two-dose inactivated SARS-CoV-2 vaccine (CoronaVac) previously, has not ...
Lairun Jin, Rong Tang, Shipo Wu, Xiling Guo, Haitao Huang, Lihua Hou, Xiaoqin Chen, Tao Zhu, Jinbo Gou, Jin Zhong, Hongxing Pan, Lunbiao Cui, Yin Chen, Xin Xia, Jialu Feng, Xue Wang, Qi Zhao, XiaoYu Xu, Zhuopei Li, Xiaoyin Zhang, Wei Chen, Jingxin Li, Fengcai Zhu   +22 more
doaj   +1 more source

Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya [PDF]

, 2012
Background: Respiratory syncytial virus (RSV) reinfects individuals repeatedly. The extent to which this is a consequence of RSV antigenic diversity is unclear.
Alexander G. Mwihuri, Anderson, Cane, Cane, Cane, Cane, Cane, Charles J. Sande, Charles N. Agoti, Choi, Clayton O. Onyango, Collins, D. James Nokes, Falsey, Falsey, Glezen, Graham F. Medley, Gunson, Hall, Hall, Hall, Henderson, Johnson, Johnson, Melero, Mufson, Mufson, Nair, Nokes, Nokes, Ohuma, Okiro, Parveen, Patricia A. Cane, Peret, Peret, Posada, Sande, Scott, Sullender, Sullender, Tamura, Trento, Trento, Trento, Venter, Waris, White, Xia, Yamaguchi, Zlateva   +50 more
core   +1 more source

Natural Design of a Stabilized Cross‐β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats

Advanced Materials, EarlyView.
We report a 3.2 Å cryoEM structure of functional amyloid protein FapC from Pseudomonas sp. UK4, an essential component of bacterial biofilm, which reveals a Greek key‐shaped protofilament, supports bioinformatically determined motifs, nuances AlphaFold predictions, emphasizes heterogeneous cross‐β stacking in amyloid cross‐seeding and shows strain ...
Yanting Jiang, Samuel Peña‐Díaz, Zhefei Zhang, Anders Ogechi Hostrup Daugberg, Marcos López Hernández, Janni Nielsen, Qiaojie Huang, Shenghan Qin, Morten K. D. Dueholm, Mingdong Dong, Jan Skov Pedersen, Qin Cao, Daniel E. Otzen, Huabing Wang   +13 more
wiley   +1 more source