Results 131 to 140 of about 186,729 (265)

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Effect of Platelet-Rich Plasma (PRP) on Dermal Skin Flap Survival: An Experimental Study in Rats. [PDF]

Cureus
Basagiannis ED, Damaskos C, Garmpis N, Papalampros A, Kykalos S, Nikiteas N.   +5 more
europepmc   +1 more source

Ex Vivo LRRK2 Activation in Asian G2385R and R1628P Variant Carriers and Idiopathic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Leucine‐rich repeat kinase 2 (LRRK2) kinase inhibition is a promising therapeutic strategy for Parkinson's disease (PD), but the functional impact of Asian‐prevalent LRRK2 p.G2385R and p.R1628P variants remains unclear. Robust patient stratification and target engagement markers are needed for global LRRK2‐targeted trials ...
Tzi Shin Toh, Lei Cheng Lit, Shen‐Yang Lim, Jia Wei Hor, Choey Yee Lew, Anis Nadhirah Khairul Anuar, Yi Wen Tay, Kirsten Black, Jia Lun Lim, Jannah Zulkefli, Kai Shi Lim, Hans Xing Ding, Shalini Padmanabhan, Azlina Ahmad‐Annuar, Eng King Tan, Dario R. Alessi, Esther Sammler, Ai Huey Tan   +17 more
wiley   +1 more source

Heterologous Prime-Boost Vaccination with GRA35-Encoding DNA and mRNA Vaccines Enhances Protective Immunity Against <i>Toxoplasma gondii</i> Infection in Mouse Models. [PDF]

Microorganisms
Chen S, Li R, Zhu Y, Sun J, Chen J.
europepmc   +1 more source

Harnessing microbial power to degrade hydrocarbon‐based plastics

mLife, EarlyView.
Abstract The growing global plastic waste crisis demands the development of urgent, effective, and sustainable solutions. While conventional recycling methods present intrinsic limitations, microbial biodegradation of plastic waste has emerged as a promising alternative.
Hui Li, Xuanyu Tao, Lina Sun, Aifen Zhou, Jizhong Zhou   +4 more
wiley   +1 more source

Engineering Pseudomonas protegens as a Targeted Antifungal-Effector Delivery Chassis via Heterologous Type III Secretion System Reconstitution. [PDF]

Microb Biotechnol
Peng Y, He S, Zhang G, Yang J, Fan R, Li C, Xie J, Long X, Qian L, Wang J, He Y, Cai H, Zhang Y, Zhang Q, Pan S, Hu S.   +15 more
europepmc   +1 more source

Effectiveness of heterologous mRNA vaccine boosters during an Omicron wave of COVID-19: a cross-sectional study in Macao (China). [PDF]

J Thorac Dis
Zhang J, Wang B, Lau E, Zeng Z, He W, Chen CLP, Chang C, Yang Z, Tong KL, Zhong N, Hon C.   +10 more
europepmc   +1 more source

Jervell and Lange‐Nielsen Syndrome Related Clinical Genetics and Experimental Models

Pediatric Discovery, EarlyView.
ABSTRACT Jervell and Lange‐Nielsen syndrome (JLNS) is defined by electrocardiographic QT prolongation and sensorineural hearing loss, caused by homozygous or compound heterozygous variants in KCNQ1 and/or KCNE1. KCNQ1 encodes the alpha subunit Kv7.1 of the ion channels accountable for slow delayed rectifier potassium currents (IKs), whereas KCNE1 ...
Yafei Zhou, Christopher L.‐H. Huang, Ying Yang, Yanmin Zhang   +3 more
wiley   +1 more source

Ethical concerns regarding heterologous COVID-19 vaccine administration

Human Vaccines & Immunotherapeutics
Somsri Wiwanitkit, Viroj Wiwanitkit
doaj   +1 more source

Cross-protective immunity elicited by heterologous DNA prime/subunit or adenovirus boost regimens against bovine viral diarrhea virus. [PDF]

BMC Vet Res
Xu M, Tao X, Gao H, Guo H, Gu X, Zhang Y, Yuan J, Li H, Wang Y, Yi J, Sheng J, Yang N, Zhang H, Chen C.   +13 more
europepmc   +1 more source