Results 11 to 20 of about 280,719 (209)

Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Human Vaccines & Immunotherapeutics, 2022
In light of intermittent supply shortages of individual vaccines and evidence of rare but serious adverse events after vaccination, heterologous regimens for COVID-19 vaccines have gained significant interest. This study aims to assess the reactogenicity
Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan   +11 more
doaj   +2 more sources

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

The Lancet, 2021
Background A heterologous recombinant adenovirus (rAd)-based vaccine, Gam-COVID-Vac (Sputnik V), showed a good safety profile and induced strong humoral and cellular immune responses in participants in phase 1/2 clinical trials.
D. Logunov, I. Dolzhikova, D. Shcheblyakov, A. Tukhvatulin, O. Zubkova, A. Dzharullaeva, A. Kovyrshina, N. Lubenets, D. Grousova, A. Erokhova, A. G. Botikov, F. Izhaeva, O. Popova, T. Ozharovskaya, I. Esmagambetov, I. Favorskaya, D. Zrelkin, Daria V. Voronina, D. Shcherbinin, A. Semikhin, Y. Simakova, E. Tokarskaya, D. Egorova, M. M. Shmarov, N. Nikitenko, V. Gushchin, E. Smolyarchuk, S. K. Zyryanov, S. Borisevich, B. Naroditsky, A. Gintsburg   +30 more
semanticscholar   +1 more source

Factors involved in heterologous expression of proteins in E. coli host

Archives of Microbiology, 2023
The production of recombinant proteins is one of the most significant achievements of biotechnology in the last century. These proteins are produced in the eukaryotic or prokaryotic heterologous hosts.
Mahin Pouresmaeil, Shahnam Azizi-Dargahlou   +1 more
semanticscholar   +1 more source

Recombination between heterologous human acrocentric chromosomes

bioRxiv, 2023
Comparisons within the human pangenome establish that homologous regions on short arms of heterologous human acrocentric chromosomes actively recombine, leading to the high rate of Robertsonian translocation breakpoints in these regions.
Andrea Guarracino, S. Buonaiuto, L. G. de Lima, T. Potapova, A. Rhie, S. Koren, B. Rubinstein, Christian Fischer, J. Gerton, A. Phillippy, V. Colonna, Erik K. Garrison   +11 more
semanticscholar   +1 more source

Protection against Different Genotypes of Newcastle Disease Viruses (NDV) Afforded by an Adenovirus-Vectored Fusion Protein and Live NDV Vaccines in Chickens

Vaccines, 2021
The efficacy of an adenovirus-vectored Newcastle disease virus (NDV) vaccine expressing the fusion (F) NDV protein (adeno-F) was evaluated against challenges with virulent heterologous and homologous NDV strains to the F protein.
Helena L. Ferreira, Patti J. Miller, David L. Suarez   +2 more
doaj   +1 more source

Heterologous prime-boost COVID-19 vaccination: initial reactogenicity data

The Lancet, 2021
There is significant international interest in heterologous prime-boost COVID-19 vaccination to mitigate against supply shocks or shortages that might otherwise reduce the speed of vaccine roll-out.
R. Shaw, A. Stuart, M. Greenland, Xinxue Liu, Jonathan S Nguyen Van-Tam, M. Snape   +5 more
semanticscholar   +1 more source

Safety and immunogenicity of heterologous boost immunisation with an orally administered aerosolised Ad5-nCoV after two-dose priming with an inactivated SARS-CoV-2 vaccine in Chinese adults: a randomised, open-label, single-centre trial

The Lancet Respiratory Medicine, 2022
Background Due to waning immunity and protection against infection with SARS-CoV-2, a third dose of a homologous or heterologous COVID-19 vaccine has been proposed by health agencies for individuals who were previously primed with two doses of an ...
Jing-xin Li, Shipu Wu, Xi-ling Guo, R. Tang, Baoying Huang, Xiaoqin Chen, Yin Chen, L. Hou, Jing-xian Liu, Jinchuan Zhong, H. Pan, F. Shi, Xiaoyu Xu, Zhuo Li, Xiaoyin Zhang, L. Cui, W. Tan, Wei Chen, F. Zhu, Jing-Xin Shi-Po Xi-Ling Rong Bao-Ying Xiao-Qin Yin Li-Hua J Li Wu Guo Tang Huang Chen Chen Hou Liu Zhong Pan S, Jing-xin Li, Shipu Wu, Xi-ling Guo, R. Tang, Baoying Huang, Xiaoqin Chen, Yin Chen, L. Hou, Jing-xian Liu, Jinchuan Zhong, H. Pan, F. Shi, Xiaoyu Xu, Zhuo Li, Xiaoyin Zhang, L. Cui, W. Tan, Wei Chen, F. Zhu, Haitao Huang, J. Gou, Weixue Si, Xue Wang, Xiao-long Zhao, T. Zhu   +44 more
semanticscholar   +1 more source

Heterologous Production of Curcuminoids [PDF]

Microbiology and Molecular Biology Reviews, 2015
SUMMARY Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for ...
J. L. Rodrigues, K. L. J. Prather, L. D. Kluskens, L. R. Rodrigues   +3 more
openaire   +3 more sources

Effectiveness of heterologous and homologous covid-19 vaccine regimens: living systematic review with network meta-analysis

British medical journal, 2022
Objective To evaluate the effectiveness of heterologous and homologous covid-19 vaccine regimens with and without boosting in preventing covid-19 related infection, hospital admission, and death. Design Living systematic review and network meta-analysis.
Wing Ying Au, P. Cheung
semanticscholar   +1 more source

Durability of immune response against omicron BA.2 and BA.4/5 and T cell responses after boosting with mRNA and adenoviral vector-based vaccines following heterologous CoronaVac/ChAdOx-1nCov-19 vaccination

Human Vaccines & Immunotherapeutics, 2023
Heterologous vaccination with inactivated vaccine followed by adenoviral vector-based vaccine has shown superiority in enhancing immune response compared to homologous primary series.
Nungruthai Suntronwong, Sitthichai Kanokudom, Thaksaporn Thatsanathorn, Thanunrat Thongmee, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan   +6 more
doaj   +1 more source