Results 11 to 20 of about 251,823 (301)

Bacterial natural product discovery by heterologous expression [PDF]

, 2023
Natural products have found important applications in the pharmaceutical and agricultural sectors. In bacteria, the genes that encode the biosynthesis of natural products are often colocalized in the genome, forming biosynthetic gene clusters.
Adjo, Kadjo, Alessandra, Eustaquio
core   +2 more sources

Heterologous production of chondroitin

Biotechnology Reports, 2022
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources. However, the known risks of animal products use have been driving the search for alternative methods and sources to obtain this compound.
Márcia R. Couto, Joana L. Rodrigues, Lígia R. Rodrigues   +2 more
openaire   +4 more sources

Heterologous Production of Curcuminoids [PDF]

Microbiology and Molecular Biology Reviews, 2015
SUMMARY Curcuminoids, components of the rhizome of turmeric, show several beneficial biological activities, including anticarcinogenic, antioxidant, anti-inflammatory, and antitumor activities. Despite their numerous pharmaceutically important properties, the low natural abundance of curcuminoids represents a major drawback for ...
J. L. Rodrigues, K. L. J. Prather, L. D. Kluskens, L. R. Rodrigues   +3 more
openaire   +3 more sources

Identification, heterologous expression, and characterization of the tolypodiol biosynthetic gene cluster through an integrated approach. [PDF]

, 2023
Cyanobacteria are tremendous producers of biologically active natural products including the potent anti-inflammatory compound tolypodiol. However, linking biosynthetic gene clusters with compound production in cyanobacteria has lagged behind other ...
Philip , Williams, Timothy J., O\u27Donnell, Kyle , Axt, Benjamin, Philmus, Daniel, Back, Juan , Vanegas, Joshua , Gurr   +6 more
core   +2 more sources

Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccine regimens in healthy adults: a prospective cohort study

Human Vaccines & Immunotherapeutics, 2022
In light of intermittent supply shortages of individual vaccines and evidence of rare but serious adverse events after vaccination, heterologous regimens for COVID-19 vaccines have gained significant interest. This study aims to assess the reactogenicity
Nasamon Wanlapakorn, Nungruthai Suntronwong, Harit Phowatthanasathian, Ritthideach Yorsaeng, Preeyaporn Vichaiwattana, Thanunrat Thongmee, Chompoonut Auphimai, Donchida Srimuan, Thaksaporn Thatsanatorn, Suvichada Assawakosri, Sitthichai Kanokudom, Yong Poovorawan   +11 more
doaj   +1 more source

Durability of immune response against omicron BA.2 and BA.4/5 and T cell responses after boosting with mRNA and adenoviral vector-based vaccines following heterologous CoronaVac/ChAdOx-1nCov-19 vaccination

Human Vaccines & Immunotherapeutics, 2023
Heterologous vaccination with inactivated vaccine followed by adenoviral vector-based vaccine has shown superiority in enhancing immune response compared to homologous primary series.
Nungruthai Suntronwong, Sitthichai Kanokudom, Thaksaporn Thatsanathorn, Thanunrat Thongmee, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan   +6 more
doaj   +1 more source

Evaluation of the Safety and Immunogenicity of Fractional Intradermal COVID-19 Vaccines as a Booster: A Pilot Study

Vaccines, 2022
Intradermal vaccination using fractional dosages of the standard vaccine dose is one strategy to improve access to COVID-19 immunization. We conducted a pilot study in healthy adults in Thailand to evaluate the safety and immunogenicity of intradermal ...
Suvimol Niyomnaitham, Somruedee Chatsiricharoenkul, Zheng Quan Toh, Sansnee Senawong, Chatkamol Pheerapanyawaranun, Supaporn Phumiamorn, Paul V. Licciardi, Kulkanya Chokephaibulkit   +7 more
doaj   +1 more source

Heterologous Biosynthesis and Genomics-Driven Derivatization of Fungal Bioactive Sesterterpenoid Variecolin [PDF]

, 2021
The biosynthetic gene cluster of fungal bioactive sesterterpenoids, variecolin (1) and variecolactone (2), was identified in Aspergillus aculeatus ATCC 16872.
Dohyun, Ahn, Ritvik, Raina, Ho Ching, Chan, Yudai, Matsuda, Inseo, Choi, Dexiu, Yan, Richard Y. C., Kong, Jemma, Arakelyan, Teng, Wan, Tsz Kiu, Cheung, Wing Lam, Yim, Maria V., Babak, Feijun, Hu, Yujeong, Kim, Kai Kap, Wong, Chun Yin, Tong, Tsz Ki, Chan, Hill Lam, Lau, Pui Yi, Ho, Ying Lo, Law, Chi Seng, Leung   +20 more
core   +2 more sources

Immunogenicity and Safety of Homologous and Heterologous Prime–Boost Immunization with COVID-19 Vaccine: Systematic Review and Meta-Analysis

Vaccines, 2022
A prime–boost strategy of COVID-19 vaccines brings hope to limit the spread of SARS-CoV-2, while the immunogenicity of the vaccines is waning over time. Whether a booster dose of vaccine is needed has become a widely controversial issue.
Haoyue Cheng, Zhicheng Peng, Shuting Si, Xialidan Alifu, Haibo Zhou, Peihan Chi, Yan Zhuang, Minjia Mo, Yunxian Yu   +8 more
doaj   +1 more source

The Pilot Study of Immunogenicity and Adverse Events of a COVID-19 Vaccine Regimen: Priming with Inactivated Whole SARS-CoV-2 Vaccine (CoronaVac) and Boosting with the Adenoviral Vector (ChAdOx1 nCoV-19) Vaccine

Vaccines, 2022
In response to the SARS-CoV-2 Delta variant, which partially escaped the vaccine-induced immunity provided by two doses of vaccination with CoronaVac (Sinovac), the National Vaccine Committee recommended the heterologous CoronaVac-ChAdOx1 (Oxford ...
Surakameth Mahasirimongkol, Athiwat Khunphon, Oraya Kwangsukstid, Sompong Sapsutthipas, Mingkwan Wichaidit, Archawin Rojanawiwat, Nuanjun Wichuckchinda, Wiroj Puangtubtim, Warangluk Pimpapai, Sakulrat Soonthorncharttrawat, Asawin Wanitchang, Anan Jongkaewwattana, Kanjana Srisutthisamphan, Daraka Phainupong, Naphatcha Thawong, Pundharika Piboonsiri, Waritta Sawaengdee, Thitiporn Somsaard, Kanokphon Ritthitham, Supaporn Chumpol, Nadthanan Pinyosukhee, Rattanawadee Wichajarn, Panadda Dhepakson, Sopon Iamsirithaworn, Supaporn Phumiamorn   +24 more
doaj   +1 more source