The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley +1 more source
The development of <i>Burkholderia</i> bacteria as heterologous hosts.
Heard SC, Eustáquio AS.
europepmc +1 more source
POTENTIATION OF THE LETHAL EFFECT OF ENDOTOXIN BY HETEROLOGOUS PLASMA [PDF]
Fritz Karl Beller+2 more
openalex +1 more source
Background and Purpose The pattern recognition receptors, formyl peptide receptors, FPR1 and FPR2, are G protein‐coupled receptors that recognize many different pathogen‐ and host‐derived ligands. While FPR1 conveys pro‐inflammatory signals, FPR2 is linked with pro‐resolving outcomes.
Denise Pajonczyk+5 more
wiley +1 more source
A 22 month prospective assessment of neutralizing and IgG antibody levels against SARS-CoV-2 variants following homologous and heterologous BNT162b2 boosting. [PDF]
Mat Yassim AS+11 more
europepmc +1 more source
Survival of Heterologous Mammalian Implants*
Harvey B. Stone+2 more
openaire +4 more sources
Abstract Background and Purpose TMEM16A Ca2+‐gated Cl− channels mediate depolarisation of contractile vascular cells. The anthelmintic niclosamide was reported to modulate the TMEM16A channel, suggesting possible repurposing for vascular pharmacology. Here, we investigate the mechanism of TMEM16A modulation by niclosamide and explore its effect on the ...
Rachel Kaye+5 more
wiley +1 more source
Oviductin sets the species-specificity of the mammalian zona pellucida. [PDF]
de la Fuente D+11 more
europepmc +1 more source
Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3
Abstract Background and Purpose Proteolytic balance is dysregulated in many diseases, with proteases playing critical roles in pathological pathways. A high level of Trypsin‐3 expression has been implicated as a significant mediator of tumour progression and metastasis, and this protease is associated with poor prognosis for patients in various cancers.
Melissa David+9 more
wiley +1 more source
Immunogenicity and Safety of Heterologous Versus Homologous Prime-Boost Regimens With BBIBP-CorV and Ad26.COV2.S COVID-19 Vaccines: A Multicentric, Randomized, Observer-Blinded Non-inferiority Trial in Madagascar and Mozambique. [PDF]
Ramgi P+39 more
europepmc +1 more source