Results 51 to 60 of about 336,027 (312)

Comparison of homologous and heterologous vaccination strategies for combating disease caused by Burkholderia pseudomallei

Frontiers in Immunology
IntroductionMelioidosis is a major cause of disease and mortality in endemic tropical regions, and the etiologic agent, Burkholderia pseudomallei, is being isolated increasingly from an expanded range of environmental and clinical sources in locations ...
Sergei S. Biryukov, Christopher K. Cote, Christopher P. Klimko, Jennifer L. Dankmeyer, Nathaniel O. Rill, Melissa Hunter, Michael L. Davies, Zander M. Hedrick, Jennifer L. Shoe, Lindsey K. Schmidt, Caitlyn E. Orne, Ju Qiu, Susan L. Welkos, Mary N. Burtnick, Mary N. Burtnick, Paul J. Brett, Paul J. Brett, David DeShazer   +17 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Comprehensive Characterization of the Transmitted/Founder env Genes From a Single MSM Cohort in China [PDF]

, 2015
Background: The men having sex with men (MSM) population has become one of the major risk groups for HIV-1 infection in China. However, the epidemiological patterns, function of the env genes, and autologous and heterologous neutralization activity in ...
Cai, F, Chen, Y, Gao, F, Huang, X, Jiang, C, Li, N, Meng, Z, Montefiori, DC, Vandergrift, N, Wu, H, Xin, R, Xu, X, Zhang, T, Zhang, X   +13 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Assembly of mitochondria [PDF]

, 1980
The majority of mitochondrial proteins are synthesized on cytoplasmic ribosomes and transferred to the mitochondria where they are assembled to supramolecular structures.
Harmey, Matthew A., Neher, Eva-Maria, Neupert, Walter, Zimmermann, Richard   +3 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Inseminação artificial e anonimato do doador Artificial insemination and donor anonymity

Revista Brasileira de Saúde Materno Infantil, 2010
Através desse trabalho, objetiva-se abordar o tema de doação de gametas e do anonimato envolvendo este ato na reprodução medicamente assistida. Analisando rapidamente o caráter técnico da doação e seleção dos gametas e a necessidade de uma legislação ...
Maria do Carmo Demasi Wanssa
doaj   +1 more source

Heterologous Expression of an Insecticidal Peptide Obtained from the Transcriptome of the Colombian Spider Phoneutria depilate

Toxins, 2023
Spider venoms are composed, among other substances, of peptide toxins whose selectivity for certain physiological targets has made them powerful tools for applications such as bioinsecticides, analgesics, antiarrhythmics, antibacterials, antifungals and ...
Julieta Vásquez-Escobar, Dora María Benjumea-Gutiérrez, Carolina Lopera, Herlinda C. Clement, Damaris I. Bolaños, Jorge Luis Higuita-Castro, Gerardo A. Corzo, Ligia Luz Corrales-Garcia   +7 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts

Frontiers in Immunology, 2018
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor ...
Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots   +12 more
doaj   +1 more source