Results 21 to 30 of about 8,883 (145)

Heterologous prime-boost: an important candidate immunization strategy against Tembusu virus [PDF]

Virology Journal, 2020
Abstract Background Tembusu virus (TMUV), a newly emerging pathogenic flavivirus, spreads rapidly between ducks, causing massive economic losses in the Chinese duck industry. Vaccination is the most effective method to prevent TMUV.
Yuting Pan, Renyong Jia, Juping Li, Mingshu Wang, Shun Chen, Mafeng Liu, Dekang Zhu, Xinxin Zhao, Ying Wu, Qiao Yang, Zhongqiong Yin, Bo Jing, Juan Huang, Shaqiu Zhang, Lin Zhang, Yunya Liu, Yanlin Yu, Bin Tian, Leichang Pan, Mujeeb Ur Rehman, Anchun Cheng   +20 more
openaire   +5 more sources

Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV [PDF]

Vaccines, 2021
The modest protective effects of the RV144 HIV-1 vaccine trial have prompted the further exploration of improved poxvirus vector systems that can yield better immune responses and protection. In this study, a recombinant lumpy skin disease virus (LSDV) expressing HIV-1 CAP256.SU gp150 (Env) and a subtype C mosaic Gag was constructed (LSDVGC5) and ...
Ros Chapman, Michiel van Diepen, Nicola Douglass, Shireen Galant, Mohamed Jaffer, Emmanuel Margolin, Phindile Ximba, Tandile Hermanus, Penny L. Moore, Anna-Lise Williamson   +9 more
openaire   +4 more sources

Comparison of multiple vaccine vectors in a single heterologous prime-boost trial [PDF]

Vaccine, 2008
The prevention of infectious disease via prophylactic immunization is a mainstay of global public health efforts. Vaccine design would be facilitated by a better understanding of the type and durability of immune responses generated by different vaccine vectors.
Brice, Barefoot, Natalie J, Thornburg, Daniel H, Barouch, Jae-Sung, Yu, Christopher, Sample, Robert E, Johnston, Hua Xin, Liao, Thomas B, Kepler, Barton F, Haynes, Elizabeth, Ramsburg   +9 more
openaire   +2 more sources

Exploring heterologous prime-boost vaccination approaches to enhance influenza control in pigs [PDF]

Veterinary Research, 2020
AbstractInfluenza A viruses evolve rapidly to escape host immunity. In swine, this viral evolution has resulted in the emergence of multiple H1 and H3 influenza A virus (IAV) lineages in the United States (US) pig populations. The heterologous prime-boost vaccination strategy is a promising way to deal with diverse IAV infection in multiple animal ...
Li, Chong, Culhane, Marie R., Cheeran, Maxim, Galina Pantoja, Lucina, Jansen, Micah L., Amodie, Deborah, Mellencamp, Martha A., Torremorell, Montserrat   +7 more
openaire   +4 more sources

Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas [PDF]

Journal of Clinical Investigation, 2019
The Epstein-Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming pathogen is available. We demonstrated that heterologous prime-boost vaccination with the nuclear antigen 1 of EBV (EBNA1), either targeted to the DEC205 receptor on DCs or expressed from a ...
Julia Rühl, Carmen Citterio, Christine Engelmann, Tracey Haigh, Andrzej Dzionek, Johannes Dreyer, Rajiv Khanna, Graham S. Taylor, Joanna B. Wilson, Carol S. Leung, Christian Münz   +10 more
openaire   +4 more sources

Heterologous prime/boost immunizations of rhesus monkeys using chimpanzee adenovirus vectors [PDF]

Vaccine, 2009
Pre-existing immunity to human adenovirus serotype 5 (AdHu5) has been shown to suppress the immunogenicity of recombinant Ad5 (rAdHu5) vector-based vaccines for human immunodeficiency virus type 1 (HIV-1) in both preclinical studies and clinical trials. As a potential solution to this problem we developed adenovirus vaccine vectors of chimpanzee origin.
Sampa, Santra, Yue, Sun, Birgit, Korioth-Schmitz, Julie, Fitzgerald, Cherie, Charbonneau, Giannina, Santos, Michael S, Seaman, Sarah J, Ratcliffe, David C, Montefiori, Gary J, Nabel, Hildegund C J, Ertl, Norman L, Letvin   +11 more
openaire   +2 more sources

Heterologous Prime-boost COVID-19 Vaccination

JK Science, 2021
There is a significant recent international interest in heterologous prime-boost COVID-19 vaccination. It may prove useful in avoiding the supply shocks or shortages that might otherwise reduce the speed of vaccine roll-out in any country including India.
Vishal R. Tandon, Annil Mahajan
openaire   +1 more source

Accelerated Heterologous Adenovirus Prime-Boost SIV Vaccine in Neonatal Rhesus Monkeys [PDF]

Journal of Virology, 2012
ABSTRACT A pediatric human immunodeficiency virus type 1 (HIV-1) vaccine would be desirable to protect infants against HIV-1 transmission from breast-feeding. Such a vaccine would need to induce protective immunity at mucosal surfaces in neonates as soon as possible after birth.
Jinyan, Liu, Hualin, Li, M Justin, Iampietro, Dan H, Barouch   +3 more
openaire   +2 more sources

Heterologous Prime/Boost Immunization of Rhesus Monkeys by Using Diverse Poxvirus Vectors [PDF]

Journal of Virology, 2007
ABSTRACT As the diversity of potential immunogens increases within certain classes of vectors, the possibility has arisen of employing heterologous prime/boost immunizations using diverse members of the same family of vectors.
Sampa, Santra, Yue, Sun, Jenny G, Parvani, Valerie, Philippon, Michael S, Wyand, Kelledy, Manson, Alicia, Gomez-Yafal, Gail, Mazzara, Dennis, Panicali, Phillip D, Markham, David C, Montefiori, Norman L, Letvin   +11 more
openaire   +2 more sources

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source