Results 21 to 30 of about 700,500 (193)

Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas [PDF]

Journal of Clinical Investigation, 2019
The Epstein-Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming pathogen is available. We demonstrated that heterologous prime-boost vaccination with the nuclear antigen 1 of EBV (EBNA1), either targeted to the DEC205 receptor on DCs or expressed from a ...
Julia Rühl, Carmen Citterio, Christine Engelmann, Tracey Haigh, Andrzej Dzionek, Johannes Dreyer, Rajiv Khanna, Graham S. Taylor, Joanna B. Wilson, Carol S. Leung, Christian Münz   +10 more
openaire   +6 more sources

Heterologous Prime-Boost Immunizations with a Virosomal and an Alphavirus Replicon Vaccine

Molecular Pharmaceutics, 2010
Heterologous prime-boost immunization strategies in general establish higher frequencies of antigen-specific T lymphocytes than homologous prime-boost protocols or single immunizations. We developed virosomes and recombinant Semliki Forest virus (rSFV) as antigen delivery systems, each capable of inducing strong CTL responses in homologous prime-boost ...
Walczak, Mateusz, de Mare, Arjan, Riezebos-Brilman, Annelies, Regts, Joke, Hoogeboom, Baukje-Nynke, Visser, Jeroen T., Fiedler, Marc, Jansen-Duerr, Pidder, van der Zee, Ate G. J., Nijman, Hans W., Wilschut, Jan, Daemen, Toos   +11 more
openaire   +4 more sources

Heterologous Prime-boost COVID-19 Vaccination

JK Science, 2021
There is a significant recent international interest in heterologous prime-boost COVID-19 vaccination. It may prove useful in avoiding the supply shocks or shortages that might otherwise reduce the speed of vaccine roll-out in any country including ...
Vishal R. Tandon, Annil Mahajan
doaj   +1 more source

Combined prime-boost vaccination against tick-borne encephalitis (TBE) using a recombinant vaccinia virus and a bacterial plasmid both expressing TBE virus non-structural NS1 protein [PDF]

BMC Microbiology, 2005
Background Heterologous prime-boost immunization protocols using different gene expression systems have proven to be successful tools in protecting against various diseases in experimental animal models.
Zakharova LG, Khoretonenko MV, Timofeev AV, Aleshin SE, Pashvykina GV, Stephenson JR, Shneider AM, Altstein AD   +7 more
doaj   +2 more sources

Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy. [PDF]

PLoS ONE, 2013
In recent years, heterologous prime-boost vaccines have been demonstrated to be an effective strategy for generating protective immunity, consisting of both humoral and cell-mediated immune responses against a variety of pathogens including HIV-1 ...
Rachel Buglione-Corbett, Kimberly Pouliot, Robyn Marty-Roix, Kim West, Shixia Wang, Egil Lien, Shan Lu   +6 more
doaj   +2 more sources

Comparison of Heterologous Prime-Boost Strategies against Human Immunodeficiency Virus Type 1 Gag Using Negative Stranded RNA Viruses. [PDF]

PLoS ONE, 2013
This study analyzed a heterologous prime-boost vaccine approach against HIV-1 using three different antigenically unrelated negative-stranded viruses (NSV) expressing HIV-1 Gag as vaccine vectors: rabies virus (RABV), vesicular stomatitis virus (VSV) and
Tessa M Lawrence, Celestine N Wanjalla, Emily A Gomme, Christoph Wirblich, Anthony Gatt, Elena Carnero, Adolfo García-Sastre, Douglas S Lyles, James P McGettigan, Matthias J Schnell   +9 more
doaj   +4 more sources

Heterologous DNA–Adenovirus Prime–Boost Strategy Expressing Bluetongue Virus VP2 and VP7 Proteins Protects Against Virulent Challenge

Vaccines
Background/Objectives: Bluetongue virus (BTV) is an emerging arbovirus causing significant economic losses in the ruminant industry. Current vaccines offer limited cross-protection against heterologous serotypes and do not enable differentiation between ...
Pablo Nogales-Altozano, Laro Gómez-Marcos, Ana Belén Carlón, Andrés Louloudes-Lázaro, Alicia Rivera-Rodríguez, Jaime Larraga, Pedro J. Alcolea, Ana Alonso, Vicente Larraga, Verónica Martín, José M. Rojas, Noemí Sevilla   +11 more
doaj   +2 more sources

Progress in DNA‐based heterologous prime‐boost immunization strategies for malaria

Immunological Reviews, 2004
Summary:  An effective vaccine against malaria is urgently required to relieve the immense human suffering and mortality caused by this parasite. A successful subunit vaccine against the liver stage of malaria will require the induction of high levels of protective T cells.
Moore, A, Hill, A
openaire   +4 more sources

Heterologous Prime-Boost Vaccination Enhances TsPmy’s Protective Immunity against Trichinella spiralis Infection in a Murine Model [PDF]

Frontiers in Microbiology, 2017
TsPmy is a paramyosin expressed by parasitic Trichinella spiralis and confers a protective immunity when its recombinant protein or DNA was used as an immunogen.
Lei Wang, Lei Wang, Ximeng Sun, Jingjing Huang, Bin Zhan, Xinping Zhu, Xinping Zhu   +6 more
doaj   +2 more sources

Heterologous prime-boost strategies for COVID-19 vaccines. [PDF]

J Travel Med, 2022
Abstract Background/Objective Heterologous prime–boost doses of COVID-19 vaccines (‘mix-and-match’ approach) are being studied to test for the effectiveness of Oxford (AZD1222), Pfizer (BNT162b2), Moderna (mRNA-1273) and Novavax (NVX-CoV2373) vaccines for COVID in ‘Com-Cov2 trial’ in UK, and ...
Sapkota B, Saud B, Shrestha R, Al-Fahad D, Sah R, Shrestha S, Rodriguez-Morales AJ.   +6 more
europepmc   +4 more sources