Results 81 to 90 of about 32,734 (287)

Analyzing immune responses to varied mRNA and protein vaccine sequences

npj Vaccines, 2023
In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have been developed against SARS-CoV-2. This has unintentionally created a unique scenario where heterologous
Hyeong-Jun Park, Yoo-Jin Bang, Sung Pil Kwon, Woori Kwak, Sang-In Park, Gahyun Roh, Seo-Hyeon Bae, Jae-Yong Kim, Hye Won Kwak, Yongkwan Kim, Soyeon Yoo, Daegeun Kim, Gyochang Keum, Eun-Kyoung Bang, So-Hee Hong, Jae-Hwan Nam   +15 more
doaj   +1 more source

Primary ChAdOx1 vaccination does not reactivate pre-existing, cross-reactive immunity

Frontiers in Immunology, 2023
Currently available COVID-19 vaccines include inactivated virus, live attenuated virus, mRNA-based, viral vectored and adjuvanted protein-subunit-based vaccines.
Larissa Henze, Larissa Henze, Julian Braun, Julian Braun, Lil Meyer-Arndt, Lil Meyer-Arndt, Lil Meyer-Arndt, Lil Meyer-Arndt, Karsten Jürchott, Karsten Jürchott, Maike Schlotz, Janine Michel, Marica Grossegesse, Maike Mangold, Maike Mangold, Manuela Dingeldey, Manuela Dingeldey, Beate Kruse, Beate Kruse, Pavlo Holenya, Norbert Mages, Norbert Mages, Norbert Mages, Ulf Reimer, Maren Eckey, Karsten Schnatbaum, Holger Wenschuh, Bernd Timmermann, Florian Klein, Florian Klein, Florian Klein, Andreas Nitsche, Claudia Giesecke-Thiel, Lucie Loyal, Lucie Loyal, Andreas Thiel, Andreas Thiel   +36 more
doaj   +1 more source

The influence of previous exposure to environmental mycobacteria on the interferon-gamma response to bacille Calmette-Guérin vaccination in southern England and northern Malawi.

, 2006
We report a large study of the effect of BCG vaccination on the in vitro 6-day whole blood interferon-gamma (IFN-gamma) response to antigens from eight species of mycobacteria among schoolchildren in south-eastern England, where bacille Calmette-Guérin ...
Crampin, A.C., Nazareth, B., Stenson, S, Branson, K, Floyd, S., Weir, RE, Branson, K., Fine, P.E.M., Sichali, L., Chaguluka, SD, Chaguluka, S.D., Donovan, L., Weir, R.E., Stanley, C., Donovan, L, Black, G.F., Nazareth, B, Stenson, S., Dockrell, H.M., Sichali, L, Crampin, AC, Dockrell, HM, Black, GF, Stanley, C, Fine, PEM, Floyd, S   +25 more
core   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

A polyepitope DNA vaccine targeted to Her-2/ErbB-2 elicits a broad range of human and murine CTL effectors to protect against tumor challenge.

, 2007
A cDNA vaccine (pVax1/pet-neu) was designed to encode 12 different Her-2/ErbB-2-derived, HLA-A*0201-restricted dominant and high-affinity heteroclitic cryptic epitopes.
Lemonnier, François A, A. M. Jackson, Alimandi, Maurizio, Jordan Marrocco, Cencioni, Giulia, S. Chouaib, Stephanie Graf-Dubois, Graf-Dubois, S, Chouaib, S, A. Scardino, Hüseyin Firat, Graf-Dubois, Stephanie, Steven G. Smith, K. Kosmatopoulos, Kosmatopoulos, K., Smith, SG, Antonio Scardino, Roberto Bei, Giulia Cencioni, S. G. Smith, G. Cencioni, P. Correale, François A. Lemonnier, Kosmatopoulos, Kostas, Faure, Olivier, Firat, Hüseyin, Olivier Faure, Firat, H, Lemonnier, FA, Jackson, AM, Kostas Kosmatopoulos, Chouaib, Salem, Correale, P, Andrew Michael Jackson, Cusi, MG, Maria Grazia Cusi, Alimandi, M, Correale, Pierpaolo, Bei, Roberto, M. G. Cusi, Marrocco, Jordan, S. Graf Dubois, F. A. Lemonnier, Smith, Steven G, Scardino, A, Cencioni, G, Pierpaolo Correale, Graf Dubois, S, Salem Chouaib, Faure, O, Marrocco, J, Kosmatopoulos, K, Scardino, Antonio, Cusi, Maria Grazia, J. Marrocco, Bei, R, R. Bei, Maurizio Alimandi, H. Firat, O. Faure, Jackson, Andrew Michael   +60 more
core   +1 more source

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants.

PLoS ONE, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 and caused the coronavirus disease 2019 (COVID-19) pandemic worldwide. As of September 2023, the number of confirmed coronavirus cases has reached over 770 million and caused ...
Se Eun Kim, So Hee Park, Woo-Jung Park, Gayeong Kim, Seo Yeon Kim, Hyeran Won, Yun-Ho Hwang, Heeji Lim, Hyeon Guk Kim, You-Jin Kim, Dokeun Kim, Jung-Ah Lee   +11 more
doaj   +1 more source

Jordanians' willingness to receive heterologous prime-boost COVID-19 vaccination and vaccine boosters.

European review for medical and pharmacological sciences, 2021
Coronavirus-2019 (COVID-19) vaccination is the game-changing approach that tops all other strategies to contain the pandemic spread. A growing interest has been raised to heterologous prime-boost and booster COVID-19 vaccination to tackle vaccine shortage and to increase the vaccine's immunogenicity.
Rababa’h, A.M., Abedalqader, N.N., Ababneh, M.   +2 more
openaire   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source