Results 121 to 130 of about 4,538 (283)

Improving results of the Fontan procedure in patients with heterotaxy syndrome

, 2006
BACKGROUND: The Fontan operation in patients with heterotaxy syndrome has been associated with a poor prognosis. We studied whether the outcome of those patients with heterotaxy syndrome improved compared with those who did not have the syndrome after an
Kim, Woong-Han, Kim, Soo-Jin, Lee, Jae Young, Lim, Hong Gook, Lee, Chang-Ha   +4 more
core   +1 more source

DUET‐seq: An Open‐Source Droplet Platform for High‐Fidelity Joint Chromatin and Transcriptome Profiling Reveals Temporal Regulatory Decoupling in Single Cells

Advanced Science, EarlyView.
DUET‐seq is an open‐source droplet platform that jointly profiles chromatin accessibility and gene expression from the same nucleus. Dissolvable dual‐linker hydrogel beads and a one‐step intra‐droplet RT‐PCR co‐index both modalities in under 12 h at roughly $0.04 per cell.
Dong Cheng, Zijun Meng, Lan Wei, Pingjing Yang, Fanfan Zhang, Zhiyi Luo, Ting Lai, Chunli Li, Mengyao Zhao, Mengqin Xu, Jiaqi Wang, Linjun Li, Huarong Chen, Jin Li, Ailong Huang, Youquan Bu, Liuyang Zhao   +16 more
wiley   +1 more source

Caval translocation as a surgical strategy for patients with congenital heart disease and bilateral superior vena cavaCentral MessagePerspective

JTCVS Techniques
Objective: The presence of bilateral superior vena cava (SVC) may complicate biventricular or single-ventricle pathway surgery. Translocation of an SVC to create a neoinnominate vein may simplify subsequent procedures. Methods: Fourteen patients received
Hani K. Najm, MD, MSc, Samuel M. Hoenig, BA, Justin Robinson, MD, Rashed Mahboubi, MD, Kaoutar Farahi, MD, John P. Costello, III, MD, Munir Ahmad, MD, Brittaney A. Potz, MD, MA, Jaehyun Lee, BS, Tara Karamlou, MD, MSc   +9 more
doaj   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Increased postoperative respiratory complications in heterotaxy congenital heart disease patients with respiratory ciliary dysfunction

, 2014
Objective(s)Congenital heart disease (CHD) and heterotaxy patients have increased postoperative and respiratory complications. We recently showed CHD-heterotaxy patients can have respiratory ciliary dysfunction (CD) similar to that associated with ...
Kuehl, Karen, Harden, Brandon, Sami, Iman, Sami-Zahkari, Iman, Leatherbury, Linda, Francis, Richard, Li, You, Olivier, Kenneth, Kureshi, Safina, Lo, Cecilia W., Swisher, Matthew, Nakhleh, Nader, Jonas, Richard A., Jonas, Richard, Tian, Xin, Hanumanthaiah, Sridhar, Giese, Rachel   +16 more
core   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Analytical Prediction of Critical Transitions in Oscillator Networks With Non‐Local Links

Advanced Science, EarlyView.
An analytical framework reveals how global coupling, second‐harmonic strength, noise, and network structure govern oscillator‐based Ising dynamics. Spectral reduction predicts stability boundaries, while Fokker–Planck analysis captures one‐ to two‐cluster transitions and identifies conditions favoring low‐energy configurations.
Qiang Li, Chumin Sun, David Waxman, Renaud Lambiotte, Jie Sun, Peng Ji   +5 more
wiley   +1 more source

ELF5‐Mediated Enhancer–Promoter Interaction Regulates LALBA Expression in Ovine Mammary Gland

Advanced Science, EarlyView.
In the study, we systematically investigate the epigenetic mechanisms underlying lactation traits in sheep by integrating transcriptomic, chromatin accessibility, histone modification, and functional analyses. We identify a super‐enhancer at the LALBA locus and demonstrate that enhancer E4 functions as its core regulatory element.
Xinmiao Wu, Jiqing Wang, Zhiyun Hao, Mingna Li, Huimin Zhen, Yuan Liu, Guoyong Zhao, Chunyan Ren, Xuelan Zhou, Haixiong Hu, Mingjie Li, Nan Shi   +11 more
wiley   +1 more source

Complex Congenital Heart Disease and Congenital Uterine Anomalies Impacting Pregnancy Outcomes

JACC: Case Reports
Complex congenital heart disease is often accompanied by extracardiac manifestations; , the significance of genitourinary involvement remains unclear. We present 3 patients with palliated complex congenital heart disease and with pregnancies complicated ...
Harrison VanDolah, MD, Tabitha Moe, MD
doaj   +1 more source

Enhancing Specific Stiffness of Nano‐Architected Materials Through Generative AI and Active Learning

Advanced Science, EarlyView.
A structure‐centric generative framework searches voxelated design space directly, coupling a variational autoencoder with multi‐objective optimization and active learning to progressively expand the validated design domain. The discovered nano‐architectures, realized as pyrolytic carbon by two‐photon lithography, deliver 18–23% higher stiffness and 26–
Jinwook Yeo, Peter Serles, Donggeun Park, Julia R. Greer, Seunghwa Ryu   +4 more
wiley   +1 more source