Results 51 to 60 of about 22,842 (259)

Contemporary perspectives on heterotopic ossification

JCI Insight, 2022
Heterotopic ossification (HO) is the formation of ectopic bone that is primarily genetically driven (fibrodysplasia ossificans progressiva [FOP]) or acquired in the setting of trauma (tHO). HO has undergone intense investigation, especially over the last 50 years, as awareness has increased around improving clinical technologies and incidence, such as ...
Charles D. Hwang, Chase A. Pagani, Johanna H. Nunez, Masnsen Cherief, Qizhi Qin, Mario Gomez-Salazar, Balram Kadaikal, Heeseog Kang, Ashish R. Chowdary, Nicole Patel, Aaron W. James, Benjamin Levi   +11 more
openaire   +3 more sources

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

Severity of heterotopic ossification in patients following surgery for hip fracture: a retrospective observational study

BMC Musculoskeletal Disorders, 2019
Background Heterotopic ossification (HO) is a relatively common complication following hip surgery treated with open reduction and internal fixation, total arthroplasty or hemiarthroplasty.
Daichi Hayashi, Elaine S. Gould, Corey Ho, Dennis L. Caruana, David E. Komatsu, Jie Yang, Chencan Zhu, Musa Mufti, James Nicholson   +8 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A new mouse model of post-traumatic joint injury allows to identify the contribution of Gli1+ mesenchymal progenitors in arthrofibrosis and acquired heterotopic endochondral ossification

Frontiers in Cell and Developmental Biology, 2022
Complex injury and open reconstructive surgeries of the knee often lead to joint dysfunction that may alter the normal biomechanics of the joint.
Jenny Magallanes, Jenny Magallanes, Nancy Q. Liu, Jiankang Zhang, Jiankang Zhang, Yuxin Ouyang, Tadiwanashe Mkaratigwa, Tadiwanashe Mkaratigwa, Fangzhou Bian, Fangzhou Bian, Ben Van Handel, Tautis Skorka, Frank A. Petrigliano, Denis Evseenko, Denis Evseenko   +14 more
doaj   +1 more source

Heterotopic Ossification: A Comprehensive Review [PDF]

JBMR Plus, 2019
ABSTRACTHeterotopic ossification (HO) is a diverse pathologic process, defined as the formation of extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair process gone awry and is a common complication of trauma and surgery. This comprehensive review seeks to synthesize the clinical, pathoetiologic, and basic biologic
Meyers, Carolyn, Lisiecki, Jeffrey, Miller, Sarah, Levin, Adam, Fayad, Laura, Ding, Catherine, Sono, Takashi, McCarthy, Edward, Levi, Benjamin, James, Aaron W   +9 more
openaire   +4 more sources

Management of heterotopic ossification affecting both hips and knees. [PDF]

, 2008
The management of heterotopic ossification is controversial. This is a rare case affecting both hips and knees of a 22-year-old woman that prevented her from walking.
Devnani, Anand Sobhraj
core  

Myositis ossificans circumscripta of the buccinator muscle: first report of a rare complication of mandibular third molar extraction. [PDF]

, 2008
Myositis ossificans is a self-limiting ossifying process that most often develops following mechanical trauma to skeletal musculature. It chiefly affects the skeletal muscles of extremities of young athletically active adult males. Myositis ossificans is
Abramovitch, Kenneth, Bouquot, Jerry, Thurber, David, Vigneswaran, Nadarajah, Wiggins, Raymond L   +4 more
core   +1 more source

Evaluation of clinical cardiac safety of zilurgisertib, an activin receptor‐like kinase‐2 (ALK2) inhibitor, in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract The oral, small molecule inhibitor of activin receptor‐like kinase‐2, zilurgisertib (INCB000928), is under evaluation in fibrodysplasia ossificans progressiva. Cardiac safety was assessed using electrocardiogram (ECG) parameters and a plasma concentration‐heart rate‐corrected QT (C‐QTc) interval analysis of pooled data from single ascending ...
Yan‐ou Yang, Hong Yang, Xing Liu, Xiaohua Gong, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

An unusual case of bowel obstruction in emergency surgery: The heterotopic mesenteric ossification

SAGE Open Medical Case Reports, 2020
The heterotopic mesenteric ossification, also known as myositis ossificans, is a rare form of heterotopic ossification, a metaplastic phenomenon where new bone is formed in the mesenteric base, generally after abdominal trauma (surgical or other).
Ricciardolo Andrea Aurelio, De Ruvo Nicola, Caramaschi Stefani, Serra Francesco, Farinetti Alberto, Mattioli Anna Vittoria, Gelmini Roberta   +6 more
doaj   +1 more source