Results 61 to 70 of about 23,475 (245)

Osificaciones heterotopicas, en pacientes sometidos a remplazo total de cadera primario mediante abordaje lateral indirecto modificado, en el Hospital Militar Central de Bogotá en los años 2005-2008 [PDF]

, 2013
La formación de osificaciones heterotópicas peri articulares después de una cirugía de la cadera es un fenómeno bien conocido, su incidencia varia ampliamente desde autores que reportan 6% hasta otros que llegan al 70%.
Arbeláez A., William R., Faria M, Pedro J., Suescun M., Juan P.   +2 more
core  

Evaluation of clinical cardiac safety of zilurgisertib, an activin receptor‐like kinase‐2 (ALK2) inhibitor, in healthy participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract The oral, small molecule inhibitor of activin receptor‐like kinase‐2, zilurgisertib (INCB000928), is under evaluation in fibrodysplasia ossificans progressiva. Cardiac safety was assessed using electrocardiogram (ECG) parameters and a plasma concentration‐heart rate‐corrected QT (C‐QTc) interval analysis of pooled data from single ascending ...
Yan‐ou Yang, Hong Yang, Xing Liu, Xiaohua Gong, Jay Getsy, Kevin Rockich   +5 more
wiley   +1 more source

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

Bone Research
Brain-derived extracellular vesicles participate in interorgan communication after traumatic brain injury by transporting pathogens to initiate secondary injury. Inflammasome-related proteins encapsulated in brain-derived extracellular vesicles can cross
Weicheng Lu, Jianfei Yan, Chenyu Wang, Wenpin Qin, Xiaoxiao Han, Zixuan Qin, Yu Wei, Haoqing Xu, Jialu Gao, Changhe Gao, Tao Ye, Franklin R. Tay, Lina Niu, Kai Jiao   +13 more
doaj   +1 more source

Clinical Aspects and Current Therapeutic Approaches for FOP

Biomedicines, 2020
Fibrodysplasia ossificans progressiva (FOP) is an extremely rare heritable disorder of connective tissues characterized by progressive heterotopic ossification in various skeletal sites.
Hiroshi Kitoh
doaj   +1 more source

Sudden death of a swimmer in water caused by heterotopic intracranial ossification and anomaly of the skull base [PDF]

, 2011
Background. Expression of immersion syndrome implies sudden and unexpected death of swimmer in water. A drowned swimmer is still a riddle for the forensic and clinical doctors.
Budakov Branislav, Gvozdenović Ljiljana, Mihalj Marija, Pilija Vladimir, Savović Slobodan   +4 more
core   +1 more source

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, Volume 13, Issue 3, 14 January 2026.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Wound breakdown reconstructed by reverse lateral arm flap after excision of heterotopic ossification of the elbow following severe burn injury: A case report

Burns Open, 2017
We report the case of a wound complication that was reconstructed by reverse lateral arm flap after excision of heterotopic ossification (HO) of the elbow in a patient with severe burns.
Akihiro Hirakawa, Yoshiyuki Ohno, Shingo Komura, Haruhiko Akiyama   +3 more
doaj   +1 more source

Heterotopic Ossification Causing Radiculopathy after Lumbar Total Disc Arthroplasty [PDF]

Asian Spine Journal, 2015
To date, no reports have presented radiculopathy secondary to heterotopic ossification following lumbar total disc arthroplasty. The authors present a previously unpublished complication of lumbar total disk arthroplasty (TDA) secondary to heterotopic ...
Keith L. Jackson, Justin M. Hire, Jeremy M. Jacobs, Charles C. Key, John G. DeVine   +4 more
doaj   +1 more source

Prophylaxis of Heterotopic Ossification in Patients Sedated after Polytrauma: Medical and Ethical Considerations [PDF]

, 2018
Background and Purpose:: Heterotopic ossification (HO) often follows acetabular fractures after multitrauma. Irradiation is a mean for prophylaxis. We established a standard procedure in our hospital for patients under sedation, when obtaining informed ...
Bosshard, Georg, Keel, Marius, Lütolf, Urs, Oertel, Susanne, Schneider, Uwe   +4 more
core  

First‐In‐Human Study to Assess the Pharmacokinetics and Safety of DS‐6016a After Single Subcutaneous Injection in Healthy Japanese Adults

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract Fibrodysplasia ossificans progressiva is a rare, progressive autosomal dominant genetic disease caused by an activin receptor‐like kinase 2 (ALK2) mutation with a need for effective prophylactic therapies. This single‐center, randomized, double‐blind, placebo‐controlled study evaluated the pharmacokinetics and safety of DS‐6016a, a novel ...
Kei Okita, Hidetoshi Furuie, Akifumi Kurata, Yasuko Owada, Satoshi Yoshiba, Kei Furihata, Takaaki Oka, Yushi Kashihara, Hitoshi Ishizuka, Kazutaka Yoshihara   +9 more
wiley   +1 more source