Results 71 to 80 of about 214,100 (302)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Growth, photosynthesis, and reactive oxygen system responses of allotriploid Populus cathayana to salt stress

Photosynthetica, 2020
Polyploid plants are generally considered to have a high stress resistance. In this study, two full sibling allotriploid populations (FDR and SDR) with different 2n female gamete sources and one diploid population (2N) obtained from the same Populus ...
T. QIU, Y. WANG, X.N. GENG, Y. ZHANG, Y. LI, X.Y. KANG   +5 more
doaj   +1 more source

A haplotype-resolved draft genome of the European sardine (Sardina pilchardus) [PDF]

, 2019
The European sardine (Sardina pilchardus Walbaum, 1792) is culturally and economically important throughout its distribution. Monitoring studies of sardine populations report an alarming decrease in stocks due to overfishing and environmental change ...
Canario, A.V.M., Cox, Cymon, De Moro, Gianluca, Garcia, Carlos, Louro, Bruno, Sabatino, Stephen J., Santos, António M., Veríssimo, Ana   +7 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Genetic Structure and Diversity of Plasmodium falciparum Merozoite Surface Proteins 1 and 2 among Children below 5 Years in Delta State, Nigeria

Biomedical and Biotechnology Research Journal
Background: Africa remains the epicenter of malaria, of which Nigeria is the country with the highest burden of the disease. The present global malaria resistant challenges call for improving pharmacogenomics, updating genomic reference panels and ...
Divine Avwerosuoghene Onobrudu, Pere-Ebi Yabrade Toloyai, Ejiro Prosper Awhin, Gabriel Otunuya Ibobo, Cyril Chukwu Dunkwu, Innocent Onyesom   +5 more
doaj   +1 more source

Effects of outbreeding depression on meristics and bilateral asymmetry in hybrids of spatially separated populations of pink salmon (Oncorhynchus gorbuscha) [PDF]

, 2005
Thesis (M.S.) University of Alaska Fairbanks, 2005Different populations of a species distributed over diverse conditions adapt to their local environments to improve their ability to survive or reproduce. Intraspecific hybridization can alter the locally
Hoover, Carrie L.
core  

Imaging correlates of molecular signatures in oligodendrogliomas. [PDF]

, 2004
Molecular subsets of oligodendroglioma behave in biologically distinct ways. Their locations in the brain, rates of growth, and responses to therapy differ with their genotypes. Retrospectively, we inquired whether allelic loss of chromosomal arms 1p and
Betensky, Rebecca A, Cairncross, J Gregory, Forsyth, Peter A, Kachur, Edward, Lee, Donald H, Louis, David N, Megyesi, Joseph F, Mizoguchi, Masahiro, Okada, Yoshifumi, Sasaki, Hikaru, Zlatescu, Magdalena C   +10 more
core   +2 more sources

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

The genome of the Pyrenean desman and the effects of bottlenecks and inbreeding on the genomic landscape of an endangered species

Evolutionary Applications, 2021
The Pyrenean desman (Galemys pyrenaicus) is a small semiaquatic mammal endemic to the Iberian Peninsula. Despite its limited range, this species presents a strong genetic structure due to past isolation in glacial refugia and subsequent bottlenecks ...
Lídia Escoda, Jose Castresana
doaj   +1 more source

On the accumulation of deleterious mutations during range expansions

, 2013
We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations co-segregate. We perform individual-based simulations of a uniform linear habitat and complement them with analytical ...
Dupanloup, Isabelle, Excoffier, Laurent, Kirkpatrick, Mark, Peischl, Stephan   +3 more
core   +1 more source