Results 1 to 10 of about 137,449 (345)

CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis [PDF]

mSphere, 2022
Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here,
Lisa Lombardi, Sean A. Bergin, Adam Ryan, Evelyn Zuniga-Soto, Geraldine Butler   +4 more
doaj   +3 more sources

JLOH: Inferring loss of heterozygosity blocks from sequencing data [PDF]

Computational and Structural Biotechnology Journal, 2023
Heterozygosity is a genetic condition in which two or more alleles are found at a genomic locus. Individuals that are the offspring of genetically divergent yet still interfertile parents (e.g. hybrids) are highly heterozygous.
Matteo Schiavinato, Valentina del Olmo, Victor Njenga Muya, Toni Gabaldón   +3 more
doaj   +2 more sources

M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis [PDF]

BMC Cancer, 2003
Background The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis and tumor suppression.
Jang Hong-Seok, Oka Yoshihiko, Killian J Keith, Brizel David M, Jamieson Timothy A, Fu Xiaolong, Clough Robert W, Vollmer Robin T, Anscher Mitchell S, Jirtle Randy L   +9 more
doaj   +2 more sources

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context [PDF]

EBioMedicine
Summary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele ...
Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom   +18 more
doaj   +2 more sources

The dynamics of loss of heterozygosity events in genomes [PDF]

EMBO Reports
Genomic instability is a hallmark of tumorigenesis, yet it also plays an essential role in evolution. Large-scale population genomics studies have highlighted the importance of loss of heterozygosity (LOH) events, which have long been overlooked in the ...
Abhishek Dutta, Joseph Schacherer
doaj   +2 more sources

Loss of Heterozygosity associated with ubiquitous environments in yeast. [PDF]

PLoS Genetics
The effect of ubiquitous environmental conditions on mutational mechanisms, particularly loss of heterozygosity (LOH) remains poorly understood. Environment induced LOH can rapidly alter the genome and promote disease progression.
Nikilesh Vijayan, Sameer Joshi, Praseetha Sarath, Koodali T Nishant   +3 more
doaj   +2 more sources

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons [PDF]

BMC Cancer, 2010
Background Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA ...
Lea Rod A, Wellwood Jeremy, Wood Peter, Jardine Paul, Green Michael R, Marlton Paula, Griffiths Lyn R   +6 more
doaj   +4 more sources

Loss of heterozygosity of TRIM3 in malignant gliomas [PDF]

BMC Cancer, 2009
Background Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies.
Dolder Béatrice, Taylor Elisabeth, Stiefel Urs, Boulay Jean-Louis, Merlo Adrian, Hirth Frank   +5 more
doaj   +4 more sources

Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report [PDF]

BMC Neurology, 2023
Background Loss of heterozygosity (LOH) at methylenetetrahydrofolate reductase (MTHFR) locus has been reported in tumor tissue. But the mutation was never reported in cerebral venous thrombosis (CVT) with hyperhomocysteinemia (HHcy) before.
Mingjie Zhang, Bingxin Shi, Mangsuo Zhao
doaj   +2 more sources

PB1836: LOSS OF HETEROZYGOSITY IN AML PATIENTS WITH INV(16) [PDF]

HemaSphere, 2023
Dmitry Bessmertniy, Zalina Fidarova, Irina Lukyanova, Natalia Risinskaya, Andrey Sudarikov   +4 more
doaj   +2 more sources