Results 1 to 10 of about 73,290 (250)

Loss Of Heterozygosity

, 2014
Author: Molecular Profiling Initiative, NCI *This method was successful in our lab using prostate tissue and for our specific objectives. Investigators must be aware that they will need to tailor the following protocol for their own research objectives and tissue under study*. This method is used to detect genomic DNA deletions in tumor cells.
openaire   +2 more sources

Loss of heterozygosity in acute leukemia: evidence of frequent submicroscopic deletions

Haematologica, 2007
Although chromosomal abnormalities are detected by conventional cytogenetic analysis (CCA) in 40–60% of patients with acute myeloid leukemia (AML), cryptic chromosomal deletions may only be detected by molecular analysis. To determine their frequency, we
Cecilia Agueli, Rosaria Basiricò, Francesco Fabbiano, Valentina Rizzo, Lucia Cascio, Giuseppe Cammarata, Anna Marfia, Maria La Rosa, Salvo Mirto, Alessandra Santoro   +9 more
doaj   +1 more source

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Nature Communications, 2016
Using mosaic analysis with double markers to label genetically-distinct clones in established tumors, the authors studied the effects of p53 loss in lung and pancreatic cancers.
Mandar Deepak Muzumdar, Kimberly Judith Dorans, Katherine Minjee Chung, Rebecca Robbins, Tuomas Tammela, Vasilena Gocheva, Carman Man-Chung Li, Tyler Jacks   +7 more
doaj   +1 more source

Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC

Scientific Reports
The initial manifestations of nasopharyngeal carcinoma (NPC) are subtle and imperceptible, leading to unfavorable clinical outcomes and limited therapeutic alternatives among Southeast Asian populations.
Yueting Wen, Ziying Zhou, Yibo Zhou, Zhongxi Huang   +3 more
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Single-Gene Deletions Contributing to Loss of Heterozygosity in Saccharomyces cerevisiae: Genome-Wide Screens and Reproducibility

G3: Genes, Genomes, Genetics, 2019
Loss of heterozygosity (LOH) is a phenomenon commonly observed in cancers; the loss of chromosomal regions can be both causal and indicative of underlying genome instability.
Kellyn M. Hoffert, Erin D. Strome
doaj   +1 more source

Prognostic impact of biomarkers in PMBCL: rationale for early integration of immune checkpoint inhibitors [PDF]

Exploration of Targeted Anti-tumor Therapy
Aim: This research aims to guide future strategies for personalized treatment of primary mediastinal large B-cell lymphoma (PMBCL), particularly to identify high-risk patients who may benefit from incorporating immune checkpoint inhibitors (ICIs) in the ...
Yana K. Mangasarova, Runiza R. Abdurashidova, Natalya V. Risinskaya, Bella V. Biderman, Tatiana V. Abramova, Vadim L. Surin, Irina A. Shupletsova, Tatiana N. Obukhova, Rasul I. Iusupov, Yulia A. Chabaeva, Aminat U. Magomedova, Lena E. Nikulina, Sergei M. Kulikov, Eugene E. Zvonkov, Alla M. Kovrigina, Andrey B. Sudarikov   +15 more
doaj   +1 more source

Application of Chromosomal Microarray Analysis in Genetic Reasons of Miscarriage Tissues

The Application of Clinical Genetics
Zhen Xu,1– 3 Na Liu,1– 3 Lu Gao,1– 3 Dongyi Yu1– 3 1Center for Medical Genetics and Prenatal Diagnosis, Shandong Provincial Maternal and Child Health Care Hospital, Affiliated to Qingdao University, Jinan, Shandong, 250000, People’s Republic of China ...
Xu Z, Liu N, Gao L, Yu D
doaj  

Loss of heterozygosity and microsatellite instability as predictive markers among Iranian esophageal cancer patients [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Variation in microsatellite sequences that are dispersed in the genome has been linked to a deficiency in cellular mismatch repair system and defects in several genes of this system are involved in carcinogenesis.
Mohammad Mahdi Forghanifard, Elham Emami Vahid, Ezzat Dadkhah, Mehran Gholamin, Samaneh Broumand Noghabi, Martha Ghahraman, Mehdi Farzadnia, Mohammad Reza Abbaszadegan   +7 more
doaj  

Loss of Heterozygosity [PDF]

, 2020
openaire   +1 more source

Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations. [PDF]

Nat Commun, 2023
Ressler AK, Snellings DA, Girard R, Gallione CJ, Lightle R, Allen AS, Awad IA, Marchuk DA.   +7 more
europepmc   +1 more source