Results 1 to 10 of about 72,764 (154)

The dynamics of loss of heterozygosity events in genomes [PDF]

EMBO Reports
Genomic instability is a hallmark of tumorigenesis, yet it also plays an essential role in evolution. Large-scale population genomics studies have highlighted the importance of loss of heterozygosity (LOH) events, which have long been overlooked in the ...
Abhishek Dutta, Joseph Schacherer
doaj   +4 more sources

JLOH: Inferring loss of heterozygosity blocks from sequencing data [PDF]

Computational and Structural Biotechnology Journal, 2023
Heterozygosity is a genetic condition in which two or more alleles are found at a genomic locus. Individuals that are the offspring of genetically divergent yet still interfertile parents (e.g. hybrids) are highly heterozygous.
Matteo Schiavinato, Valentina del Olmo, Victor Njenga Muya, Toni Gabaldón   +3 more
doaj   +2 more sources

Loss of heterozygosity of TRIM3 in malignant gliomas [PDF]

BMC Cancer, 2009
Background Malignant gliomas are frequent primary brain tumors associated with poor prognosis and very limited response to conventional chemo- and radio-therapies.
Dolder Béatrice, Taylor Elisabeth, Stiefel Urs, Boulay Jean-Louis, Merlo Adrian, Hirth Frank   +5 more
doaj   +5 more sources

A new method to detect loss of heterozygosity using cohort heterozygosity comparisons [PDF]

BMC Cancer, 2010
Background Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor and patient-matched normal DNA ...
Lea Rod A, Wellwood Jeremy, Wood Peter, Jardine Paul, Green Michael R, Marlton Paula, Griffiths Lyn R   +6 more
doaj   +6 more sources

Loss of heterozygosity of CYP2D6 enhances the sensitivity of hepatocellular carcinomas to talazoparibResearch in context [PDF]

EBioMedicine
Summary: Background: Loss of heterozygosity (LOH) diminishes genetic diversity within cancer genomes. A tumour arising in an individual heterozygous for a functional and a loss-of-function (LoF) allele of a gene occasionally retain only the LoF allele ...
Xiaonan Zhang, Natallia Rameika, Lei Zhong, Verónica Rendo, Margus Veanes, Snehangshu Kundu, Sandro Nuciforo, Jordan Dupuis, Muhammad Al Azhar, Ioanna Tsiara, Pauline Seeburger, Shahed Al Nassralla, Viktor Ljungström, Richard Svensson, Ivaylo Stoimenov, Per Artursson, Markus H. Heim, Daniel Globisch, Tobias Sjöblom   +18 more
doaj   +2 more sources

Loss of Heterozygosity associated with ubiquitous environments in yeast. [PDF]

PLoS Genetics
The effect of ubiquitous environmental conditions on mutational mechanisms, particularly loss of heterozygosity (LOH) remains poorly understood. Environment induced LOH can rapidly alter the genome and promote disease progression.
Nikilesh Vijayan, Sameer Joshi, Praseetha Sarath, Koodali T Nishant   +3 more
doaj   +2 more sources

Loss of Heterozygosity and Its Importance in Evolution. [PDF]

J Mol Evol, 2023
AbstractLoss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread in organisms that have asexual reproduction like budding yeasts, and is also an important and frequent mutation event in tumorigenesis.
Smukowski Heil C.
europepmc   +3 more sources

Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Pharmaceuticals, 2021
Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes.
Xiaonan Zhang, Tobias Sjöblom
doaj   +3 more sources

PB1836: LOSS OF HETEROZYGOSITY IN AML PATIENTS WITH INV(16) [PDF]

HemaSphere, 2023
Dmitry Bessmertniy, Zalina Fidarova, Irina Lukyanova, Natalia Risinskaya, Andrey Sudarikov   +4 more
doaj   +2 more sources

Loss of heterozygosity exploited for collateral lethality-based cancer therapy [PDF]

EBioMedicine
Hai Fang
doaj   +2 more sources