Results 11 to 20 of about 173,415,106 (290)

Polyploidy as an Adaptation against Loss of Heterozygosity in Cancer. [PDF]

Int J Mol Sci, 2022
Polyploidy is common in cancer cells and has implications for tumor progression and resistance to therapies, but it is unclear whether it is an adaptation of the tumor or the non-adaptive effect of genomic instability.
Archetti M.
europepmc   +2 more sources

Loss of Heterozygosity and Its Importance in Evolution. [PDF]

J Mol Evol, 2023
AbstractLoss of heterozygosity (LOH) is a mitotic recombination event that converts heterozygous loci to homozygous loci. This mutation event is widespread in organisms that have asexual reproduction like budding yeasts, and is also an important and frequent mutation event in tumorigenesis.
Smukowski Heil C.
europepmc   +3 more sources

Insignificant effects of loss of heterozygosity in HLA in the efficacy of immune checkpoint blockade treatment [PDF]

, 2022
Background: It is assumed that loss of heterozygosity and allelic copy loss in HLA gene is associated with poor response rates in immune checkpoint inhibitor treatment. H-owever, the accurate extents or consistency in cancer types have not been explored.
김상우, Eunyoung Kim, Sangwoo Kim, Yohan Yang   +3 more
core   +1 more source

Diploid-specific genome stability genes of S. cerevisiae: genomic screen reveals haploidization as an escape from persisting DNA rearrangement stress. [PDF]

, 2011
Maintaining a stable genome is one of the most important tasks of every living cell and the mechanisms ensuring it are similar in all of them. The events leading to changes in DNA sequence (mutations) in diploid cells occur one to two orders of magnitude
Skoneczna, Adrianna, Malgorzata Alabrudzinska, Marek Skoneczny, Alabrudzinska Malgorzata, Skoneczna Adrianna, Skoneczny Marek, Alabrudzinska, Malgorzata, Skoneczny, Marek, Adrianna Skoneczna   +8 more
core   +3 more sources

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples

BMC Research Notes, 2017
Background Intratumor heterogeneity has been demonstrated in several cancer types, following a model of branched evolution. It is unknown to which extent intratumor heterogeneity is applicable to esophageal adenocarcinoma. Therefore the aim of this study
Anna M. J. van Nistelrooij, Ronald van Marion, Linetta B. Koppert, Katharina Biermann, Manon C. W. Spaander, Hugo W. Tilanus, J. Jan B. van Lanschot, Bas P. L. Wijnhoven, Winand N. M. Dinjens   +8 more
doaj   +1 more source

Molecular and clinicopathological analysis of three cases of gastric juvenile polyposis

JGH Open, 2022
Background and Aim Juvenile polyposis (JP) is a rare disease known to be associated with mutations either in SMAD4/BMPR1A. JP is known to often develop into malignant tumors, with a reported probability of 9–50%.
Yuya Yamashiro, Yuka Yanai, Tsutomu Takeda, Takuo Hayashi, Yoichi Akazawa, Noboru Yatagai, Hiroya Ueyama, Hidetaka Eguchi, Akihito Nagahara, Takashi Yao, Tsuyoshi Saito   +10 more
doaj   +1 more source

Evaluation of Heterozygosity Loss in STR-Loci of Tumor DNA in Multiple Myeloma Patients with Plasmacytoma Based on the Molecular Analysis of Complex Archival Tumor Samples

Клиническая онкогематология, 2022
Background. Multiple myeloma (MM) is a hematological malignancy with plasma cells as substrate. Sometimes MM is characterized by plasmacytomas, i.e., intra- and extraosseous tumors.
Elena Evgen’evna Nikulina, M. V. Firsova, N. V. Risinskaya, Ya. A. Kozhevnikova, M. V. Solov’ev, T. V. Abramova, T. N. Obukhova, A. M. Kovrigina, A. B. Sudarikov, L. P. Mendeleeva   +9 more
doaj   +1 more source

High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study

BMC Cancer, 2012
Background The aim of the study was to evaluate potential chemotherapy-induced microsatellite instability, loss of heterozygosity, loss of expression in mismatch repair proteins and associations with clinical findings in breast cancer patients ...
Kamat Nasir, Khidhir Mohammed A, Jaloudi Mohammed, Hussain Sabir, Alashari Mouied M, Al Qawasmeh Khaled H, Rannug Ulf   +6 more
doaj   +1 more source

Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors [PDF]

Clinical and Experimental Otorhinolaryngology, 2014
ObjectivesTo evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors.MethodsEighty thyroid tumor cases (20 follicular adenomas, 10 follicular ...
Jin Hwan Kim, Kyu Young Choi, Dong Jin Lee, Young-Soo Rho, Sung-Jin Jo   +4 more
doaj   +1 more source

Supplementary Data from Pan-cancer Analysis of Homologous Recombination Repair–associated Gene Alterations and Genome-wide Loss-of-Heterozygosity Score

, 2022
Supplementary Data from Pan-cancer Analysis of Homologous Recombination Repair–associated Gene Alterations and Genome-wide Loss-of-Heterozygosity ...
C. Benedikt Westphalen (10971768), Joaquin Mateo (14956032), Fabrice André (15038378), Shridar Ganesan (34638), Jorge-Antonio Lopez (15038384), Volker Heinemann (2793574), Etienne Rouleau (15009254), Alexander D. Fine (15038375), Clare Turnbull (146523), Luis Garcia Palacios (15038381), Ethan S. Sokol (8807147)   +10 more
core   +1 more source