Results 11 to 20 of about 137,449 (345)

Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Pharmaceuticals, 2021
Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes.
Xiaonan Zhang, Tobias Sjöblom
doaj   +3 more sources

Loss of heterozygosity exploited for collateral lethality-based cancer therapy [PDF]

EBioMedicine
Hai Fang
doaj   +2 more sources

Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes: A meta-analysis. [PDF]

World J Gastrointest Oncol
Song YH, Li WL, Yang Z, Gao Y, Feng ZP.
europepmc   +2 more sources

p120 catenin is required for the stress response in Drosophila [PDF]

, 2013
p120ctn is a ubiquitously expressed core component of cadherin junctions and essential for vertebrate development. Surprisingly, Drosophila p120ctn (dp120ctn) is dispensable for adherens junctions and development, which has discouraged Drosophila ...
Bauer, Christin, Stefanatos, Rhoda K., Vidal, Marcos   +2 more
core   +7 more sources

Chytrid fungus infection in alpine tree frogs is associated with individual heterozygosity and population isolation but not population-genetic diversity [PDF]

, 2020
Chytridiomycosis, a disease caused by the emerging fungus Batrachochytrium dendrobatidis (Bd), has been implicated in the decline of over 500 amphibian species.
Banks, Sam C., Fraser, Ceridwen I., Hunter, David, Jack, Cameron, Macris, Amy, Scheele, Ben C.   +5 more
core   +2 more sources

Targeting tumor vulnerabilities associated with loss of heterozygosity

Molecular & Cellular Oncology, 2020
We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 ...
Veronica Rendo, Ivaylo Stoimenov, Tobias Sjöblom   +2 more
doaj   +1 more source

Pretransplant HLA typing revealed loss of heterozygosity in the major histocompatibility complex in a patient with acute myeloid leukemia [PDF]

, 2019
Introduction Chromosomal abnormalities are frequent events in hematological malignancies. The degree of HLA compatibility between donor and recipient in hematopoietic stem cell transplantation is critical.
Breman, Amy M., Britton, Rebecca M., Cui, Connie P., Farag, Sherif S., Kashi, Zahra, Krueger-Sersen, Mary, Littrell, Courtney A., Lobashevsky, Andrew L., Martin, Russ K., Singh, Susmita, Vance, Gail H.   +10 more
core   +1 more source

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples

BMC Research Notes, 2017
Background Intratumor heterogeneity has been demonstrated in several cancer types, following a model of branched evolution. It is unknown to which extent intratumor heterogeneity is applicable to esophageal adenocarcinoma. Therefore the aim of this study
Anna M. J. van Nistelrooij, Ronald van Marion, Linetta B. Koppert, Katharina Biermann, Manon C. W. Spaander, Hugo W. Tilanus, J. Jan B. van Lanschot, Bas P. L. Wijnhoven, Winand N. M. Dinjens   +8 more
doaj   +1 more source

Molecular and clinicopathological analysis of three cases of gastric juvenile polyposis

JGH Open, 2022
Background and Aim Juvenile polyposis (JP) is a rare disease known to be associated with mutations either in SMAD4/BMPR1A. JP is known to often develop into malignant tumors, with a reported probability of 9–50%.
Yuya Yamashiro, Yuka Yanai, Tsutomu Takeda, Takuo Hayashi, Yoichi Akazawa, Noboru Yatagai, Hiroya Ueyama, Hidetaka Eguchi, Akihito Nagahara, Takashi Yao, Tsuyoshi Saito   +10 more
doaj   +1 more source

Evaluation of Heterozygosity Loss in STR-Loci of Tumor DNA in Multiple Myeloma Patients with Plasmacytoma Based on the Molecular Analysis of Complex Archival Tumor Samples

Клиническая онкогематология, 2022
Background. Multiple myeloma (MM) is a hematological malignancy with plasma cells as substrate. Sometimes MM is characterized by plasmacytomas, i.e., intra- and extraosseous tumors.
Elena Evgen’evna Nikulina, M. V. Firsova, N. V. Risinskaya, Ya. A. Kozhevnikova, M. V. Solov’ev, T. V. Abramova, T. N. Obukhova, A. M. Kovrigina, A. B. Sudarikov, L. P. Mendeleeva   +9 more
doaj   +1 more source