Results 31 to 40 of about 173,415,106 (290)

Loss of heterozygosity (LOH) and mutation in sporadic vestibular schwannomas.

, 2013
Loss of heterozygosity (LOH) and mutation in sporadic vestibular schwannomas.
Won-Sang Lee (205635), Jong Dae Lee (145287), Tae Jun Kwon (205631), Un-Kyung Kim (145294)   +3 more
core   +1 more source

TP53 Abnormalities are frequent and early events in the sequential pathogenesis of gallbladder carcinoma§

Annals of Hepatology, 2005
Background: Gallbladder carcinoma (GBC) is a frequent neoplasm in Hispanic and native American populations. GBC is preceded by gallstones, chronic cholecystitis and dysplastic changes of the gallbladder epithelium.
Mauricio Moreno, Fernando Pimentel, Adi F. Gazdar, Ignacio I. Wistuba, Juan F. Miquel   +4 more
doaj   +1 more source

Loss of heterozygosity in the VNTR region of intron 1 of p53 in two retinoblastoma cases

, 1996
Loss of heterozygosity (LOH) was studied in 10 primary retinoblastoma tumors in the VNTR region of intron 1 in p53 gene by the polymerase chain reaction. To our knowledge mutations have not been reported in the p53 gene in retinoblastoma primary tumours.
Emre, SERAP, Ozguc, M, Bilgic, S, Sungur, A, Gunalp, I, Buyukpamukcu, M   +5 more
core   +1 more source

Characterization of phenotypic variation and genome aberrations observed among Phytophthora ramorum isolates from diverse hosts

BMC Genomics, 2018
Background Accumulating evidence suggests that genome plasticity allows filamentous plant pathogens to adapt to changing environments. Recently, the generalist plant pathogen Phytophthora ramorum has been documented to undergo irreversible phenotypic ...
Marianne Elliott, Jennifer Yuzon, Mathu Malar C, Sucheta Tripathy, Mai Bui, Gary A. Chastagner, Katie Coats, David M. Rizzo, Matteo Garbelotto, Takao Kasuga   +9 more
doaj   +1 more source

Patterns of Genomic Instability in Interspecific Yeast Hybrids With Diverse Ancestries

Frontiers in Fungal Biology, 2021
The genomes of hybrids often show substantial deviations from the features of the parent genomes, including genomic instabilities characterized by chromosomal rearrangements, gains, and losses.
Devin P. Bendixsen, David Peris, David Peris, Rike Stelkens   +3 more
doaj   +1 more source

Microsatellite Instability and Loss of Heterozygosity in Melanoma

Journal of Investigative Dermatology, 1995
Alterations in the repeat length of microsatellites have been identified recently in tumors arising in patients with hereditary nonpolyposis colon cancer and in several human sporadic tumors. We examined 40 sporadic melanomas and their corresponding nontumorous skin for microsatellite instability (MSI) and loss of heterozygosity (LOH) at chromosomes 2q,
Peris, Ketty, Keller, G, Chimenti, S, Amantea, A, Kerl, H, Höfler, H.   +5 more
openaire   +3 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

heterozygosity-fitness

, 2017
the file contains Standardized multilocus heterozygosity calculated at 37 putatively neutral markers as well as at 6 MHC-linked markers and fitness data of 147 male Alpine ibex of Gran Paradiso National Park (Italy).
Keller, Lukas, Bassano, Bruno, Lukas Keller (214772), Christine Grossen (220855), Grossen, Christine, Brambilla, Alice, Bruno Bassano (760901), Alice Brambilla (3271320)   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of heterozygosity and loss of expression of the DCC gene in gastric cancer

, 1998
Aim - To investigate the role of DCC gene inactivation in the development and progression of gastric cancer. Methods - Loss of heterozygosity and loss of expression of the DCC gene was studied in 51 surgical specimens of gastric cancer using detection ...
Fang, Dian-Chun, Jass, Jeremy R., Wang, Dong-Xu   +2 more
core   +1 more source