Results 21 to 30 of about 173,415,106 (290)

Loss of heterozygosity (LOH)--implications for human genetic identification.

Folia Histochemica et Cytobiologica, 2009
The aim of this study was assessment of possible effects of loss of heterozygosity on human genetic identification of histolopathogical tissue sections. DNA templates were extracted from tumour tissue specimens excised from oncological patients and from ...
Jerzy Janica, Tomasz Filipowski, Leszek Kozłowski, Renata Zalewska, Marek Rogowski, Małgorzata Skawrońska, Ireneusz Sołtyszewski, Witold Pepiński   +7 more
doaj   +1 more source

The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination

mBio, 2018
The opportunistic fungal pathogen Candida albicans lacks a conventional sexual program and is thought to evolve, at least primarily, through the clonal acquisition of genetic changes. Here, we performed an analysis of heterozygous diploid genomes from 21
Joshua M. Wang, Richard J. Bennett, Matthew Z. Anderson   +2 more
doaj   +1 more source

Age at diagnosis and loss of heterozygosity on chromosome 1p and 19q in oligodendroglial tumors [PDF]

, 2006
The age distribution and incidence of loss of heterozygosity (LOH) of 1p and 19q was analyzed in 85 oligodendroglial tumors WHO II and III. The peak of tumor manifestation was in the age group of 35 to 55 years.
Moschopulos, M., Roelcke, U, Vassella, E, Laeng, H, Huber, A, Hergersberg, M., Mariani, L., Murtin, C., Weis, J, Landolt, H., Laeng, H., Murtin, C, Hergersberg, M, Weis, Joachim, Landolt, H, Moschopulos, M, Mariani, L, Vassella, E., Huber, A., Roelcke, U.   +19 more
core   +3 more sources

Tumor Suppressor Genes on the 16q24.3 Breast Cancer Loss of Heterozygosity Region

, 2022
Tumor Suppressor Genes on the 16q24.3 Breast Cancer Loss of Heterozygosity ...
Anthony J Bais (13285305)
core   +1 more source

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Nature Communications, 2020
Allelic losses occurring in cancer cells have been suggested as potential targets for therapy. Here, the authors show how recurring loss of heterozygosity of a drug metabolic gene in colorectal cancers can be exploited using a low molecular weight ...
Veronica Rendo, Ivaylo Stoimenov, André Mateus, Elin Sjöberg, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Adrian Ng, Casey OʼBrien, Marios Giannakis, Per Artursson, Peter Nygren, Ian Cheong, Tobias Sjöblom   +13 more
doaj   +1 more source

Value of the loss of heterozygosity to BRCA1 variant classification

npj Breast Cancer, 2022
At least 10% of the BRCA1/2 tests identify variants of uncertain significance (VUS) while the distinction between pathogenic variants (PV) and benign variants (BV) remains particularly challenging.
Elizabeth Santana dos Santos, Amanda B. Spurdle, Dirce M. Carraro, Adrien Briaux, Melissa Southey, Giovana Torrezan, Ambre Petitalot, Raphael Leman, Philippe Lafitte, kConFab Investigators, Didier Meseure, Keltouma Driouch, Lucy Side, Carole Brewer, Sarah Beck, Athalie Melville, Alison Callaway, Françoise Revillion, Maria A. A. Koike Folgueira, Michael T. Parsons, Heather Thorne, Anne Vincent-Salomon, Dominique Stoppa-Lyonnet, Ivan Bieche, Sandrine M. Caputo, Etienne Rouleau   +25 more
doaj   +1 more source

Genome-scale patterns in the loss of heterozygosity incidence in Saccharomyces cerevisiae [PDF]

, 2022
Former studies have established that loss of heterozygosity can be a key driver of sequence evolution in unicellular eukaryotes and tissues of metazoans.
Tomala, Katarzyna, Korona, Ryszard, Piróg, Adrian, Tutaj, Hanna, Adrian Pirog, Ryszard Korona, Hanna Tutaj, Katarzyna Tomala   +7 more
core   +1 more source

Familial Adenomatous Polyposis: Analysis of Genetic Instability of Microsatellites Loci and Genetic Alternations of Tumor Suppressor Genes

Biomolecules & Biomedicine, 2008
Familial adenomatous polyposis (FAP) is an autosomal dominant illness with the highest risk for appearance of colorectal cancer’s disease. In our study, we have used Bethesda criteria that define colorectal cancers which can be tested on microsatellite ...
Vesna Hadžiavdić, Izet Eminović, Mensura Aščerić, Radovan Komel   +3 more
doaj   +1 more source

The cell cycle stage of bovine zygotes electroporated with CRISPR/Cas9-RNP affects frequency of Loss-of-heterozygosity editing events

Scientific Reports, 2022
At the embryonic level, CRISPR technologies have been used to edit genomes reliably and efficiently in various mammalian models, with Ribonucleoprotein (RNP) electroporation potentially representing a superior delivery method into mammalian zygotes ...
Dennis Miskel, Mikhael Poirier, Luisa Beunink, Franca Rings, Eva Held, Ernst Tholen, Dawit Tesfaye, Karl Schellander, Dessie Salilew-Wondim, Carina Blaschka, Christine Große-Brinkhaus, Brenig Bertram, Michael Hoelker   +12 more
doaj   +1 more source

Loss of heterozygosity (LOH) and Hardy-Weinberg equilibrium.

, 2019
Loss of heterozygosity (LOH) and Hardy-Weinberg equilibrium.
Michael Behring (6312380), Isam-Eldin Eltoum (6312386), Sooryanarayana Varambally (259521), Han Yu (110573), Chandrakumar Shanmugam (187138), Upender Manne (187180), Trafina Jadhav (754142), Andra Frost (6312383), Shantel Hebert-Magee (6312377)   +8 more
core   +1 more source