Results 51 to 60 of about 137,449 (345)

Using Microsatellites to Assess Genetic Variation in a Selective Breeding Program of Chinese Bay Scallop (Argopecten irradians irradians) [PDF]

, 2013
This study aimed to improve our understanding of the genetics of the Chinese bay scallop (Argopecten irradians irradians), one of the most important maricultured shellfish in China.
Li Li., Zhang G., Zhang S.
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. [PDF]

, 2012
Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centrioles duplicate once per cell cycle, and duplication is coordinated by Polo-like kinase 4 (Plk4).
Bettencourt-Dias, Monica, Chen, Denaly, Cleveland, Don W, Da Cruz, Sandrine, Fachinetti, Daniele, Holland, Andrew J, Lince-Faria, Mariana, Parish, Nicole, Verma, Inder M, Vitre, Benjamin, Zhu, Quan   +10 more
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Loss of heterozygosity and carrier identification in Duchenne muscular dystrophy: a familiar case with recombination event

Revista Ciencias de la Salud, 2012
Duchenne/Becker Muscular Dystrophy (DMD/BMD) is an X-linked recessive disease characterizedby muscular weakness. It is caused by mutations on the dystrophin gen.
Fonseca-Mendoza Dora Janeth, Mateus-Arbeláez Heidi, Silva-Aldana Claudia Tamar   +2 more
doaj  

A simple approach for classifying new mutations as somatic or germinal in DNA samples lacking paired tissue

BioTechniques, 2014
When studying mutations in DNA samples, determining whether novel sequence changes are somatic mutations or germline polymorphisms can be difficult. Here we describe a novel and very simple approach for identification of somatic mutations and loss of ...
Ignacio Erquiaga, Cristina Hurtado, Paula Aranaz, Francisco J. Novo, José L. Vizmanos   +4 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Selection for heterozygosity gives hope to a wild population of inbred wolves. [PDF]

PLoS ONE, 2006
Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations.
Staffan Bensch, Henrik Andrén, Bengt Hansson, Hans Chr Pedersen, Håkan Sand, Douglas Sejberg, Petter Wabakken, Mikael Akesson, Olof Liberg   +8 more
doaj   +1 more source

Genome-wide signatures of population bottlenecks and diversifying selection in European wolves [PDF]

, 2013
Genomic resources developed for domesticated species provide powerful tools for studying the evolutionary history of their wild relatives. Here we use 61K single-nucleotide polymorphisms (SNPs) evenly spaced throughout the canine nuclear genome to ...
Greco, C., Jedrzejewska, B., Jedrzejewski, W., Ostrander, E. A., Pilot, M., Randi, E., Sidorovich, V. E., vonHoldt, B. M., Wayne, R. K.   +8 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source