Results 51 to 60 of about 173,415,106 (290)

Suppression of HSF1 activity by wildtype p53 creates a driving force for p53 loss-of-heterozygosity

, 2021
The vast majority of human tumors with p53 mutations undergo loss of the remaining wildtype p53 allele (loss-of-heterozygosity, p53LOH). p53LOH has watershed significance in promoting tumor progression.
Neesse, Albrecht, Isermann, Tamara; Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen, Germany, Winkler, Nadine; Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen, Germany, Li, Jinyu, Şener, Özge Çiçek, Neesse, Albrecht; Department of Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Göttingen, Göttingen, Germany, Stender, Adrian, Stender, Adrian; Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen, Germany, Isermann, Tamara, Klemke, Luisa, Winkler, Nadine, Şener, Özge Çiçek; Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen, Germany, Li, Jinyu; Department of Pathology, Stony Brook University, Stony Brook, USA, Klemke, Luisa; Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen, Germany, Wegwitz, Florian, Moll, Ute M.; Department of Pathology, Stony Brook University, Stony Brook, USA, Moll, Ute M., Schulz-Heddergott, Ramona, Wegwitz, Florian; Department of Gynecology and Obstetrics, University Medical Center Göttingen, Göttingen, Germany, Schulz-Heddergott, Ramona; Institute of Molecular Oncology, University Medical Center Göttingen, Göttingen, Germany, Tamara Isermann, Jinyu Li, Adrian Stender, Luisa Klemke, Ute M. Moll, Ramona Schulz-Heddergott, Özge Çiçek Şener, Albrecht Neesse, Nadine Winkler, Florian Wegwitz   +29 more
core   +1 more source

Loss of heterozygosity and carrier identification in Duchenne muscular dystrophy: a familiar case with recombination event

Revista Ciencias de la Salud, 2012
Duchenne/Becker Muscular Dystrophy (DMD/BMD) is an X-linked recessive disease characterizedby muscular weakness. It is caused by mutations on the dystrophin gen.
Fonseca-Mendoza Dora Janeth, Mateus-Arbeláez Heidi, Silva-Aldana Claudia Tamar   +2 more
doaj  

mSphere of Influence: Considering Complex Mutational Processes That Shape Microbial Virulence

mSphere, 2019
Matt Anderson works in the field of genetics and infectious disease, with a focus on the human fungal pathogen Candida albicans. In this mSphere of Influence article, he reflects on how two papers, “Gene Flow Contributes to Diversification of the Major ...
Matthew Zack Anderson
doaj   +1 more source

CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis

mSphere, 2022
Genetic manipulation is often used to study gene function. However, unplanned genome changes (including single nucleotide polymorphisms [SNPs], aneuploidy, and loss of heterozygosity [LOH]) can affect the phenotypic traits of the engineered strains. Here,
Lisa Lombardi, Sean A. Bergin, Adam Ryan, Evelyn Zuniga-Soto, Geraldine Butler   +4 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The Role of Nitric Oxide in Resolution of Vasospasam Corresponding with Cerebral Vasospasms after Subarachnoid Haemorrhage: Animal Model

Biomolecules & Biomedicine, 2008
Intracranial aneurysmal rupture is the common cause of spontaneous subarachnoid haemorrhage (SAH). This haemorrhage is typically diffuse and located in extracerebral subarachnoid space in which main cerebral arterial branches are situated.
Kemal Dizdarević
doaj   +1 more source

Selection for heterozygosity gives hope to a wild population of inbred wolves. [PDF]

PLoS ONE, 2006
Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f), a finding that may have dramatic consequences for the management of endangered populations.
Staffan Bensch, Henrik Andrén, Bengt Hansson, Hans Chr Pedersen, Håkan Sand, Douglas Sejberg, Petter Wabakken, Mikael Akesson, Olof Liberg   +8 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Loss of heterozygosity analysis of case No.1.

, 2013
A comparison of lymphocyte DNA and tumor DNA using the flanking, D22S268 and D22S275, and intragenic, D22S929, microsatellite markers in the NF2 gene region. In case, three markers showed loss of heterozygosity by allele loss in the tumor DNA.
Won-Sang Lee (205635), Jong Dae Lee (145287), Tae Jun Kwon (205631), Un-Kyung Kim (145294)   +3 more
core   +1 more source

Loss of heterozygosity in colorectal cancer [PDF]

, 2012
Colorectal cancer (CRC) is one of the most common malignancies in the world. The development and progression of CRC is a multistep process, which involves many dietary and environmental factors.
Aytekin, T, Ozaslan, M
core   +1 more source