Results 81 to 90 of about 214,100 (302)

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Mixture or mosaic? Genetic patterns in UK grey squirrels support a human-mediated ‘long-jump’ invasion mechanism [PDF]

, 2016
Aim Clarifying whether multiple introductions of a species remain relatively isolated or merge and interbreed is essential for understanding the dynamics of invasion processes.
Carbone, C, Lurz, P, Reuman, D, Signorile, L, Wang, J   +4 more
core   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Potato soup: analysis of cultivated potato gene bank populations reveals high diversity and little structure

Frontiers in Plant Science
Cultivated potatoes are incredibly diverse, ranging from diploid to pentaploid and encompass four different species. They are adapted to disparate environments and conditions and carry unique alleles for resistance to pests and pathogens.
Heather K. Tuttle, Alfonso H. Del Rio, John B. Bamberg, Laura M. Shannon   +3 more
doaj   +1 more source

Genetic Diversity and Ancestral Relationships of Red Junglefowls and Domestic Chickens in Southeast Asia

The Journal of Poultry Science, 2014
In the present study, we have explored the genetic relationships between red junglefowls and domestic chickens in Southeast Asia by using single nucleotide polymorphism (SNP) markers.
Riztyan, Kotaro Kawabe, Takeshi Shimogiri, Yasuhiro Kawamoto, Worawut Rerkamnuaychoke, Takao Nishida, Shin Okamoto   +6 more
doaj   +1 more source

Estimation of linkage disequilibrium in a sample of the United Kingdom dairy cattle population using unphased genotypes [PDF]

, 2003
The association between genetic marker alleles was estimated for two regions of the bovine genome from a random sample of 50 young dairy bulls born in the United Kingdom between 1988 and 1995. Microsatellite marker genotypes were obtained for six markers
Knott, S A, Smith, D, Tenesa, A, Visscher, P M, Ward, D, Williams, J L   +5 more
core  

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Genome-Wide Association Study (GWAS) on Reproductive Seasonality in Indigenous Greek Sheep Breeds: Insights into Genetic Integrity

Current Issues in Molecular Biology
A key feature in sheep biology is reproduction seasonality which concerns the cyclical occurrence of natural breeding, which therefore does not take place throughout the year.
Danai Antonopoulou, George Symeon, Konstantinos Zaralis, Meni Avdi, Ilias S. Frydas, Ioannis A. Giantsis   +5 more
doaj   +1 more source

Heterozygosity in apomictic organisms

Hereditas, 2008
Pamilo, P. 1987. Heterozygosity in apomictic organisms. —Hereditus 207: 95–101. Lund, Sweden. ISSN 0018–0661. Received November 19, 1986 New mutations generally occur as heterozygotes. In the absence of recombination. e.g., in apomictic organisms, the affected loci remain heterozygous and the number of heterozygous loci per individual increases.
openaire   +2 more sources