Results 231 to 240 of about 81,851 (305)

Evaluating the 8‐Year Association Between Cognition and Beta Amyloid in the Dallas Lifespan Brain Study Cohort

Brain and Behavior, Volume 16, Issue 9, September 2026.
The present study investigated the 8‐year association between beta amyloid (Aβ) and cognitive decline to weigh in on the validity of the amyloid cascade hypothesis, which posits that Aβ drives the downstream processes leading to cognitive decline in Alzheimer's disease (AD).
Joshua David, Isabella Torres, Evan Smith, Ekarin Pongpipat, Denise Park   +4 more
wiley   +1 more source

Hypotheses for the Adaptive Maintenance of Phenotypic Polymorphisms. [PDF]

Ecol Evol
Falk JJ, Webster MS, Rubenstein DR.
europepmc   +1 more source

Critical role of cellular communication network factor 1 in early osteogenesis of mesenchymal stem cells primed by low‐intensity pulsed ultrasound and bone morphogenetic protein 2

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Cooperative stimulation of mechanical stress and osteoinductive factor, such as BMP‐2, enhances BMP signaling via the upregulation of BMP receptors. As a result, CCN1 production is increased and is secreted to the extracellular environment. Secreted CCN1 promotes Runx2 expression through interaction with integrin, leading to early osteogenic ...
Hsu Myat Paing, Satoshi Kubota, Masaharu Takigawa, Takuo Kuboki, Takashi Nishida   +4 more
wiley   +1 more source

MTHFR C677T and A1298C polymorphisms in dementia susceptibility: evidence from a meta-analytic investigation with disease-specific and ethnicity-stratified analyses. [PDF]

Front Aging Neurosci
He Y, Shi Y, Hu J, Wang X, Su J, Yang Z, Zhang Z, Liao S, Lu X, Zhu X.   +9 more
europepmc   +1 more source

Ganoderic Acid A Ameliorates Pentylenetetrazol‐Induced Epilepsy in Mice via Activating KCNQ2

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
GA‐A binds and activates KCNQ2, thereby reducing epileptic‐like EEG discharges, the loss and apoptosis of hippocampal neurons, and improving anxiety and depression‐like behavioral changes. In addition, GA‐A inhibits neuroinflammation and alleviates oxidative stress independent of activating KCNQ2.
Yang Yao, Zhujun Liu, Xujiao Wang, Cunhao Bian, Rui Wang, Yukun Zhang   +5 more
wiley   +1 more source

Familial hypobetalipoproteinemia in pediatric patients with fatty liver: an under-recognized cause. [PDF]

Front Med (Lausanne)
Loberman Nachum N, Shteyer E, Cohen H, Chorin O, Granot M, Weiss B.   +5 more
europepmc   +1 more source

Does Next Generation Sequencing (NGS)‐Based CYP2D6 Sequencing Improve Genotype–Phenotype Concordance in Tamoxifen‐Treated Patients?

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 731-744, September 2026.
CYP2D6 metabolizes about 20% of commonly used drugs, including tamoxifen, a major hormone therapy for breast cancer. Although the relationship between tamoxifen pharmacokinetics and CYP2D6 genotype has been demonstrated, residual variability in drug exposure remains unexplained.
Jeanne Petit, Julien Plenecassagnes, Aurelie Brice, Florence Dalenc, Ludovic Mallet, Etienne Chatelut, Ayman Al Saati, Fabienne Thomas   +7 more
wiley   +1 more source

Papillary Thyroid Carcinoma, Bilateral Macronodular Adrenal Cortical Disease-Related Cortisol Excess, and Femoral Enchondroma: A Novel Phenotype-Genotype Based on Next-Generation Sequencing (Variants of <i>APC, MSH6</i>, and <i>CACNA1S</i> Genes). [PDF]

Diagnostics (Basel)
Carsote M, Schipor SV, Dumitrascu A, Gheorghe AM, Sima OC, Manda D, Costachescu M, Muresan A, Preda EM, Terzea D.   +9 more
europepmc   +1 more source

Impact of increased population size and three reference genomes on the development of linkage maps in alfalfa

Crop Science, Volume 66, Issue 5, September/October 2026.
Abstract Alfalfa (Medicago sativa L.) is an important perennial forage crop and a highly heterozygous autotetraploid species (2n = 4x = 32), making high‐density linkage mapping challenging. This study evaluated the effects of reference genome choice and population size on the development of genetic linkage maps using genotyping‐by‐sequencing‐derived ...
Harpreet Kaur, Melinda Dornbusch, Laura M. Shannon, Deborah A. Samac   +3 more
wiley   +1 more source

Estimating Effective Number of Breeders Under the Heterozygote-Excess Equilibrium. [PDF]

Mol Ecol Resour
Yang B, Wang D, Shen Y, Li W, Wang H, Wang R, Peng R, Zhang S, Xia Z, Dunn DW, Huang K, Li B.   +11 more
europepmc   +1 more source