Results 211 to 220 of about 78,400 (304)

Association of SPHK1 polymorphisms with Alzheimer's disease susceptibility: Functional impact of the rs2247856 SNP on transcriptional efficiency

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION Sphingosine kinase 1 (SPHK1) has been implicated in the regulation of pro‐resolving lipid mediators relevant to neuroinflammation in Alzheimer's disease (AD). However, no studies have evaluated the genetic association between SPHK1 polymorphisms and AD susceptibility.
Dong‐Ju Kim, Yong‐Chan Kim, Byung‐Hoon Jeong   +2 more
wiley   +1 more source

Contributions of selenoproteins to breast cancer etiology and racial disparity. [PDF]

Cancer Causes Control
Bera S, Liu L, Ma W, Xu Z, Sverdlov M, Deaton R, Macias V, Valyi-Nagy K, Kajdacsy-Balla A, Hoskins K, Wiley EL, Kastrati I, Diamond AM.   +12 more
europepmc   +1 more source

The Indiana University Brain Health Program to deliver amyloid‐targeted therapy to Alzheimer's disease patients

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.
Abstract INTRODUCTION The Indiana University Brain Health Program was developed to support safe implementation of amyloid‐targeting therapies (ATTs) for early Alzheimer's disease (AD). METHODS We established Neurology Brain Health Navigators (neuroBHNs) to extend our Brain Health Navigator model into specialty care.
Jared R. Brosch, Sophia Wang, Liana G. Apostolova, Atul Agarwal, Jason W. Allen, Laurie Gutmann, Meredith Tobar, Linda Gonzalez, Dontraelle Johnson, Lindsay Treadway, Julie Connolly, Angela Tang, Ethan Lettich, Sam Davies, Nancy Kuhn, Dustin B. Hammers, David Clark, Martin Farlow, Deanna R. Willis, Nicole Fowler, Donna M. Wilcock   +20 more
wiley   +1 more source

A Practical Framework for GT‐Seq Panel Optimization

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Genotyping‐in‐thousands by sequencing (GT‐seq) panels are powerful tools in ecological, evolutionary and conservation genomics, yet the optimization process critical for robust and reproducible genotyping remains poorly formalized. Here, we present an iterative workflow for GT‐seq panel optimization that emphasizes systematic refinement ...
Chandika RG, Caitlin N. Ott‐Conn, Peter T. Euclide, Julie A. Blanchong, Angela Schmoldt, Randy W. DeYoung, Daniel P. Walsh, Wes A. Larson, Emily K. Latch   +8 more
wiley   +1 more source

A feasibility study of whole genome germline testing as an adjunct screening tool in a UK general private practice. [PDF]

Sci Rep
Jones AB, Pichert G, Side L, Homfray T, McVeigh T, Hicks S, Williams C, Pellerin D, Cirigliano V, Leon M, Palao B, Izquierdo L, Ordonez E, Gongora E, Davies C, Healy J, Thomas R, Narayanan P, Al Shakarchi G, Amin Z, Dadaev T, Bancroft E, Kote-Jarai Z, Eeles R, Sandberg M.   +24 more
europepmc   +1 more source

Early Epidemiologic and Immune Predictors of Atopic Dermatitis: Reduced Cord Blood Regulatory B10 Cells in the Munich Atopy Prediction Study (MAPS)

Allergy, Volume 81, Issue 7, Page 2463-2477, July 2026.
In this prospective birth cohort from Munich, comprehensive clinical assessments and longitudinal lifestyle questionnaires were combined with cord blood immune profiling. Infants who later developed AD showed altered cord blood immune signatures, including reduced CD4+ T cells, increased B cells and markedly decreased Breg cells. Epidemiologic factors,
S. Preis, S. Kaesler, M. Koeberle, M. Hils, B. Evers, R. L. Silva, Y. Skabytska, L. Schellenberger, H. Hufnagel, M. Schielein, B. Kuschel, Y. Amar, A. Zink, T. Biedermann, Z. Kurgyis   +14 more
wiley   +1 more source

Different larval habitats and insecticide resistance frequency of Anopheles sinensis in Ganghwagun, Incheon, South Korea. [PDF]

Sci Rep
Eom TH, Lee HY, Hong H, Lee E, Lee J, Eun JH, Seo S, Goh Y, Lee E, Yeo SJ.   +9 more
europepmc   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Straightened Small Pinnae in TRPV4 c.1024G>T Heterozygous Cats. [PDF]

Anim Genet
Matsumoto Y, Ishii R, Ukawa H, Hiyoshi-Kanemoto S, Hayashi H, Onishi H, Ataka K, Horie R.   +7 more
europepmc   +1 more source