Results 201 to 210 of about 114,605 (302)

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, Volume 13, Issue 28, 18 May 2026.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Advancing dual gene therapy for SFTPC deficiency. [PDF]

Mol Ther
Clark RDE, Hanna M, Kolls JK.
europepmc   +1 more source

The Geographical Distribution of Lactose Tolerance‐Associated Alleles 13910*T and 13915*G Is Strongly Linked to Male Founder Events in Eurasia

American Journal of Human Biology, Volume 38, Issue 5, May 2026.
ABSTRACT Lactose tolerance (lactase persistence) represents a very progressive human adaptation, the origins of which remain incompletely understood. This study aims to examine the geographical distribution of the two alleles associated with lactose tolerance in Eurasia (13910*T and 13915*G) in relation to the main Y haplogroups and autosomal ancestry ...
Pavel Grasgruber
wiley   +1 more source

Genetic Diversity and Gene Flow of the Ectomycorrhizal Mushroom <i>Lactarius hatsudake</i> in Southern China: Evidence from SSR Markers. [PDF]

J Fungi (Basel)
Yang S, Mao M, Huang J, Gu B, Zhao K.
europepmc   +1 more source

Oncogenetic testing, diagnosis and follow-up in Birt-Hogg-Dubé syndrome, familial atypical multiple mole melanoma syndrome and neurofibromatosis 1 and 2 [PDF]

, 2015
't Kint de Roodenbeke, Daphné, Baurain, Jean-François, Brochez, Lieve, Caplanusi, Teofila, Claes, Kathleen, Hulstaert, Frank, Legius, Eric, Poppe, Bruce, Robays, Jo, Rottey, Sylvie, Schrijvers, Dirk, Stordeur, Sabine, Ullman, Urielle, Van Maerken, Tom   +13 more
core  

Association of plasma biomarkers with amyloid and tau PET in pre‐dementia stages

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Measuring plasma biomarkers effectively assesses early‐stage Alzheimer's disease. METHODS Subjects were categorized as cognitively unimpaired (CU) (n = 66), CU with subjective cognitive decline (SCD) (n = 100), and mild cognitive impairment (MCI) (n = 25).
Allal Boutajangout, Arjun V. Masurkar, Ricardo Osorio, Ludovic Debure, Mobeena Ghuman, Wajiha Ahmed, Alok Vedvyas, Elizabeth Pirraglia, Jon Links, Louisa Bokacheva, Brianna Vega, Mark A. Bernard, Karyn Marsh, Omonigho M Bubu, Yongzhao Shao, Joshua Chodosh, Henry Rusinek, Thomas Wisniewski   +17 more
wiley   +1 more source

Preparing for Shotgun Sequencing in Forensic Genetics-A Workflow for Analysis of Monozygotic Twins. [PDF]

Genes (Basel)
Meyer OL, Børsting C, Andersen JD, Kampmann ML.   +3 more
europepmc   +1 more source

Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler, Min Sung Gee, Katie O'Gara, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Yueh‐Hao Lu, Nellie Kwang, Kate I. Tsourmas, Christiana Prekopa, Zechuan Shi, Heidi Yahan Liang, Sherilyn D. Collins, Zachary A. Pashkutz, Jenna A. Sanchez, Kai‐Xuan Shi, Amber D. Walker, Shuling Wang, Maigan L. A. Wong, Karina Genaro, Jonathan Neumann, Angela Gomez‐Arboledas, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Ali Mortazavi, Vivek Swarup, Grant R. MacGregor, Kim N. Green   +29 more
wiley   +1 more source

Escape from X inactivation drives sex differences in gene expression. [PDF]

Mol Biol Evol
Zhu C, Xu L, Harpak A.
europepmc   +1 more source

DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long‐Term Survival in Ischemic Stroke: A Prospective Cohort Study

Annals of Neurology, Volume 99, Issue 5, Page 1210-1223, May 2026.
Objective Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation.
B. Díaz‐Benito, P. Calleja, L. Alzamora, A. Ruiz‐García, A. Martínez‐Salio, M. Muñoz‐García, F. Ostos, A. García‐Culebras, A. Moraga, M.A. Moro, I. Lizasoain   +10 more
wiley   +1 more source