Results 1 to 10 of about 299,280 (207)

Severe Multivessel Coronary Artery Disease in an Adolescent With Genetic Dyslipidemia

JACC: Case Reports
Background: Familial hypercholesterolemia is characterized by lifelong elevations in low-density lipoprotein cholesterol (LDL-C) that, when left untreated, markedly increase the risk of premature atherosclerotic cardiovascular disease (ASCVD).
Venessa Thorsen, MSc, George Slim, MD, Navaneetha Saskikumar, MD, Kevin R. Bainey, MD, MSc, Anita Y.M. Chan, MD, PhD, Robert A. Hegele, MD, PhD, Michael Khoury, MD   +6 more
doaj   +1 more source

Primary coronary artery pseudoaneurysm in a patient with familial hypercholesterolemia

Clinical Case Reports, 2019
Rare primary coronary artery pseudoaneurysms in a young patient with heterozygous FH was successfully repaired with direct closure of intimal defects with aneurysmorrhaphy.
Toshiki Fujiyoshi, Masaki Kano, Hitoshi Ogino   +2 more
doaj   +1 more source

Coronary artery bypass grafting in a 14-year-old boy with compound heterozygous LDLR familial hypercholesterolemia: a case report

Frontiers in Pediatrics
Familial hypercholesterolemia (FH), particularly homozygous or compound heterozygous forms, predisposes individuals to premature cardiovascular disease due to severely elevated low-density lipoprotein cholesterol (LDL-C).
Ke Zhu, Fuqiang Zhang, Jin Wang, Chunjing Li   +3 more
doaj   +1 more source

Quantification of low density lipoprotein binding and cholesterol accumulation by single human fibroblasts using fluorescence microscopy.

Journal of Lipid Research, 1980
Using fluorescence microscopy, we have quantified low density lipoprotein (LDL) binding by indirect immunofluorescence and cellular cholesterol with the fluorescent sterol-binding polyene, filipin, in individual cultured human fibroblasts from normal ...
H S Kruth, M Vaughan
doaj   +1 more source

PCSK9 inhibitor failure in a statin-intolerant FH patient with a novel LDLR variant: a case report

Frontiers in Cardiovascular Medicine
BackgroundApproximately 3.8 million patients in China suffer from familial hypercholesterolemia (FH). Statins and PCSK9 inhibitors are recommended by guidelines as therapeutic agents.
Yuan Li, Huiyan Jiang, Yajuan Xiong, Simin Yan, Xin Chen   +4 more
doaj   +1 more source

Early‐onset familial hypercholesterolemia: A case of extensive xanthomas and premature coronary artery disease

Clinical Case Reports
Key Clinical Message Early recognition and management of familial hypercholesterolemia (FH) are crucial, especially in patients with extensive xanthomas and premature coronary artery disease.
Harsimran Kalsi, Ankur Singla, Sukhjot Kaur, Amogh Verma, Nathnael Abera Woldehana, Sarvesh Rustagi, Mahendra Pratap Singh   +6 more
doaj   +1 more source

LDL Receptor Gene-ablated Hamsters: A Rodent Model of Familial Hypercholesterolemia With Dominant Inheritance and Diet-induced Coronary Atherosclerosis

EBioMedicine, 2018
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease caused mainly by LDL receptor (Ldlr) gene mutations. Unlike FH patients, heterozygous Ldlr knockout (KO) mice do not show a dominant FH trait.
Xin Guo, Mingming Gao, Yunan Wang, Xiao Lin, Liu Yang, Nathan Cong, Xiangbo An, Feng Wang, Kai Qu, Liqing Yu, Yuhui Wang, Jinjie Wang, Haibo Zhu, Xunde Xian, George Liu   +14 more
doaj   +1 more source

Life Course Approach for Managing Familial Hypercholesterolemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Treatment of familial hypercholesterolemia is directed toward the moment of the medical encounter. However, risk for heart disease as a consequence of having familial hypercholesterolemia is related to lifelong exposure to elevated low‐density ...
Samuel S. Gidding, Dirk J. Blom, Brian McCrindle, Uma Ramaswami, Raul D. Santos, Gerald F. Watts, Albert Wiegman   +6 more
doaj   +1 more source

Alirocumab—a novel drug for familial hypercholesterolemia

National Journal of Physiology, Pharmacy and Pharmacology, 2016
Familial hypercholesterolemia (FH) is a genetically transmitted condition, wherein abnormally high levels of total cholesterol and low density lipoproteins (LDL) are seen.
Priyanka Kamath, Preethi J Shenoy
doaj   +1 more source

Lipoprotein metabolism in familial hypercholesterolemia: Serial assessment using a one-step ultracentrifugation method

Practical Laboratory Medicine, 2015
Objectives: It is well known that familial hypercholesterolemia (FH) is a common inherited disorder that can markedly elevate the level of plasma LDL cholesterol.
Hayato Tada, Masa-aki Kawashiri, Atsushi Nohara, Akihiro Inazu, Hiroshi Mabuchi, Masakazu Yamagishi, Kenshi Hayashi   +6 more
doaj   +1 more source