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Pediatric implications of heterozygous familial hypercholesterolemia
, 2003 openaire +2 more sources
Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia [PDF]
New England Journal of Medicine, 2020 Familial hypercholesterolemia is characterized by an elevated level of low-density lipoprotein (LDL) cholesterol and an increased risk of premature atherosclerotic cardiovascular disease. Monoclonal antibodies directed against proprotein convertase subtilisin-kexin type 9 (PCSK9) have been shown to reduce LDL cholesterol levels by more than 50% but ...
Lawrence A Leiter +2 more
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Heterozygous Familial Hypercholesterolemia: Prevalence and Control Rates
Expert Review of Endocrinology and Metabolism, 2021Introduction: Heterozygous familial hypercholesterolemia (heFH) is associated with a very high risk for cardiovascular events. Treatment with potent statins substantially reduces cardiovascular morbidity in these patients. Moreover, combination therapy with statins plus ezetimibe and/or proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors ...
Konstantinos Tziomalos +1 more
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Heterozygous Familial Hypercholesterolemia
Circulation, 2016Familial hypercholesterolemia (FH) is a genetic condition that causes high low-density lipoprotein (LDL) cholesterol (sometimes referred to as bad cholesterol) from birth. FH means high cholesterol that runs in a family. FH is caused by specific DNA changes that are passed on from parents to their children. It is not caused by lifestyle factors such as
Angela, Onorato, Amy C, Sturm
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The Detection of Heterozygous Familial Hypercholesterolemia in Ireland
Advances in Therapy, 2012Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant condition with a population prevalence of 1 in 500, and is associated with significant cardiovascular morbidity and mortality. It may be caused by mutations in the low-density lipoprotein (LDL) receptor, apolipoprotein B100 (Apo B100), or proprotein convertase subtilisin/kexin ...
O'Kane, Maurice J +6 more
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Diet in Children Heterozygous for Familial Hypercholesterolemia
Archives of Pediatrics & Adolescent Medicine, 1977Effects of a cholesterol- and saturate-poor, polyunsaturate-rich diet on plasma total and low-density lipoprotein (LDL) cholesterol levels were assessed in 23 children between the ages of 2 and 7 who were heterozygous for well-documented familial hypercholesterolemia.
C J, Glueck +3 more
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Severe xanthomatosis in heterozygous familial hypercholesterolemia
Journal of Clinical Lipidology, 2018Familial hypercholesterolemia is a genetic lipoprotein disorder characterized by elevated plasma low-density lipoprotein cholesterol level, (tendinous xanthomas, xanthelasmas, and premature arcus corneus) and early onset atherosclerotic cardiovascular disease. Familial hypercholesterolemia is caused by mutations in the low-density lipoprotein receptor,
Sumayah, Aljenedil +3 more
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Peripheral Arterial Disease in Heterozygous Familial Hypercholesterolemia
Atherosclerosis, 2015Familial hypercholesterolemia is characterized by elevated plasma cholesterol and early coronary arterial disease onset. However, few studies investigated the association of heterozygous familial hypercholesterolemia with peripheral arterial disease.In a cross sectional study 202 heterozygous familial hypercholesterolemia patients (91% confirmed by ...
Raul D Santos, Antonio E Pesaro
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Identification of people with heterozygous familial hypercholesterolemia
Current Opinion in Lipidology, 2012Familial hypercholesterolemia is an underdiagnosed autosomal codominant genetic condition associated with significantly increased risk of early cardiovascular disease when untreated. Early diagnosis and treatment decrease the excess risk, and strategies for identification of affected individuals are being developed worldwide.
Annie, Haase, Anne C, Goldberg
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