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Serum apolipoproteins in heterozygous familial hypercholesterolemia
Clinica Chimica Acta, 1992In order to characterize the abnormalities of the lipoprotein profile in familial hypercholesterolemia (FH), serum apolipoprotein AI, AII, B, CII, CIII, and E levels were determined by the turbidimetric immunoassay in 48 patients with heterozygous FH. Apolipoprotein B levels in FH were about 2.5 fold higher (203 +/- 48 mg/dl, mean +/- S.D.) than the 30
K, Kajinami +3 more
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Coronary artery disease in heterozygous familial hypercholesterolemia
Atherosclerosis, 1982Serum lipids, lipoproteins and Achilles tendon thickness in 52 patients with heterozygous familial hypercholesterolemia (FH) were investigated in order to clarify what are the important factors for the development of coronary artery disease (CAD) in heterozygous FH patients.
K, Hirobe +6 more
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Evolocumab in Children with Heterozygous Familial Hypercholesterolemia
New England Journal of Medicine, 2020Heterozygous familial hypercholesterolemia — in contrast to the more rare and more severe homozygous familial hypercholesterolemia — is a common genetic cholesterol disorder affecting approximately...
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Heterozygous familial hypercholesterolemia presenting as chylomicronemia syndrome
Journal of Clinical Lipidology, 2017Heterozygous familial hypercholesterolemia (HeFH) is characterized by a twofold elevation in low-density lipoprotein cholesterol. Severe elevations in triglycerides are an uncommon manifestation. In this case report, we discuss an atypical presentation of the chylomicronemia syndrome in a patient with HeFH.
Robert S. Rosenson +2 more
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Adrenocortical Response to Adrenocorticotropin in Heterozygous Familial Hypercholesterolemia*
The Journal of Clinical Endocrinology & Metabolism, 1984Receptor-mediated uptake of low density lipoproteins (LDL) provides an important source of cholesterol for corticosteroid synthesis by human adrenocortical cells grown in tissue culture. Recent studies have indicated an impaired adrenocortical response to prolonged ACTH stimulation in patients with abetalipoproteinemia (who lack plasma LDL) and in ...
D R, Illingworth, N A, Alam, S, Lindsey
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Treatment of heterozygous familial hypercholesterolemia: atorvastatin versus simvastatin
Atherosclerosis Supplements, 2001This study compares the cholesterol-lowering efficacy of atorvastatin and simvastatin in attainment of the National Cholesterol Education Program (NCEP) guidelines LDL-cholesterol (LDL-C) goal in patients with heterozygous familial hypercholesterolemia (HFH).
BO, Mario +5 more
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Heterozygous familial hypercholesterolemia case study
Journal of the American Academy of Nurse Practitioners, 2010Abstract Purpose: To examine a case of heterozygous familial hypercholesterolemia (HeFH) in a primary care setting and to review the epidemiology, pathophysiology, etiology, and treatment guidelines to reduce the mortality related to this disease process. Data Sources: Findings from the history, physical exam, and laboratory results of a young French
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Novel Treatment Options for the Management of Heterozygous Familial Hypercholesterolemia
Expert Review of Clinical Pharmacology, 2017Even though statins represent the mainstay of treatment of heterozygous familial hypercholesterolemia (FH), their low-density lipoprotein cholesterol (LDL-C) lowering efficacy is finite and most patients with FH will not achieve LDL-C targets with statin monotherapy.
Konstantinos Tziomalos +1 more
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Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia
Atherosclerosis, 2004Familial hypercholesterolemia (FH) is a genetic disorder of lipoprotein metabolism characterized by very high plasma concentrations of low density lipoprotein cholesterol (LDLc), tendon xanthomas and increased risk of premature coronary heart disease (CHD). FH is a public health problem throughout the world.
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Safety and efficacy of mipomersen in patients with heterozygous familial hypercholesterolemia
Atherosclerosis, 2019Heterozygous familial hypercholesterolemia (HeFH) is a common genetic disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) and increased cardiovascular disease risk. Despite multiple LDL-C-lowering therapies, many HeFH patients do not reach LDL-C targets. Mipomersen, an antisense oligonucleotide against apolipoprotein B (apoB),
Laurens F. Reeskamp +6 more
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