Results 101 to 110 of about 1,758,089 (240)

TSTScope Unifies Single‐Cell Multi‐Omics to Identify Functional T Cell States Predictive of Immunotherapy Response

Advanced Science, EarlyView.
TSTScope is an interpretable AI framework that integrates single‐cell transcriptomes with TCR information through curated gene‐program constraints. By linking receptor context to functional T cell states, it reveals response‐associated tumor‐specific T cell programs in lung cancer immunotherapy cohorts and defines an MPR score associated with ...
Shiwei Cao, Jinyu Cheng, Feng‐ao Wang, Chenxin Yi, Jiajun Chen, Keyue Wang, Lulu Liu, Junwei Liu, Yixue Li   +8 more
wiley   +1 more source

Application of Heuristic Algorithms in the Tomography Problem for Pre-Mining Anomaly Detection in Coal Seams. [PDF]

Sensors (Basel), 2022
Brociek R, Pleszczyński M, Zielonka A, Wajda A, Coco S, Lo Sciuto G, Napoli C.   +6 more
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

A Comparison of Metaheuristic Algorithms for Structural Optimization: Performance and Efficiency Analysis

Advances in Civil Engineering
Optimization challenges effectively mirror numerous complex real-world problems. These are typically addressed using two methodologies: approximate methods and exact methods. Within the approximate category, meta-heuristic methods are prominent.
Saeedeh Ghaemifard, Amin Ghannadiasl
doaj   +1 more source

Comparison of heuristic approaches for the multiple depot vehicle scheduling problem [PDF]

Given a set of timetabled tasks, the multi-depot vehicle scheduling problemis a well-known problem that consists of determining least-cost schedulesfor vehicles assigned to several depots such that each task is accomplishedexactly once by a vehicle.
Hertz, A., Huisman, D., Pepin, A.S., Desaulniers, G.   +3 more
core  

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

Application analysis of heuristic algorithms integrating dynamic programming in RNA secondary structure prediction

Intelligent Systems with Applications
Ribonucleic acid is a crucial biomolecule in living organisms, with various types. To promote the research process of ribonucleic acid function, this study is for analyzing the utilization of heuristic algorithms on the ground of fusion dynamic ...
Tao Yuan, Xu Yan
doaj   +1 more source

Application of Meta-Heuristic Algorithms for Training Neural Networks and Deep Learning Architectures: A Comprehensive Review. [PDF]

Neural Process Lett, 2022
Kaveh M, Mesgari MS.
europepmc   +1 more source

A heuristic procedure for one dimensional bin packing problem with additional constraints [PDF]

We proposed a heuristic algorithm to solve the one-dimensional bin-packing problem with additional constraints. The proposed algorithm has been applied to solve a practical vehicle-allocation problem.
Venkata Rao, V., Tirupati Devanath, Kumar Satyendra   +2 more
core  

STWave: Fine‐Scale Spatial Structure Discovery in Microscopic‐Resolution Spatial Transcriptomics via Patchwise Wavelet Graphs

Advanced Science, EarlyView.
STWave transforms massive microscopic‐resolution spatial transcriptomics into interpretable fine‐scale tissue maps through patch‐wise inference, wavelet‐based multi‐scale encoding, and dual‐domain reconstruction. It reduces noise while preserving weak spatial signals, enabling efficient analysis of 6 40 000 spots of 2.47 GB GPU memory and revealing ...
Tao Jiang, Songming Zhang, Xiaofeng Chen, Xiongtao Xiao, Wenming Cao, Weikai Li, Tong Zhao, Bing Li, Xinyue Xu, Zhongshan Li   +9 more
wiley   +1 more source