Results 31 to 40 of about 17,549 (208)

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Cross-Species Transmission of Swine Hepatitis E Virus Genotype 3 to Rabbits

Viruses, 2020
Hepatitis E virus (HEV) is a quasi-enveloped, positive-sense single stranded RNA virus. HEV continually expands the host ranges across animal species.
Sang-Hoon Han, Byung-Joo Park, Hee-Seop Ahn, Yong-Hyun Kim, Hyeon-Jeong Go, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, Sang-Won Lee, Yang-Kyu Choi, In-Soo Choi   +10 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Ribavirin as a First Treatment Approach for Hepatitis E Virus Infection in Transplant Recipient Patients

Microorganisms, 2019
The hepatitis E virus (HEV) is the major cause of acute hepatitis of viral origin worldwide. Despite its usual course as an asymptomatic self-limited hepatitis, there are highly susceptible populations, such as those with underlying immunosuppression ...
Antonio Rivero-Juarez, Nicolau Vallejo, Pedro Lopez-Lopez, Ana Isabel Díaz-Mareque, Mario Frias, Aldara Vallejo, Javier Caballero-Gómez, María Rodríguez-Velasco, Esther Molina, Antonio Aguilera   +9 more
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Characterisation and evaluation of predisposing factors for the development of xanthinuria in dogs with leishmaniosis under allopurinol therapy

Parasites & Vectors
Background Allopurinol, one of the drugs routinely used to treat canine leishmaniosis (CanL), is an inhibitor of the enzyme xanthine oxidase, which plays a fundamental role in purine metabolism.
Sara Clemente Oliveira, Carolina Arenas, Marina Domínguez-Ruiz, Eva Prosper, Maria Joana Dias, Rodolfo Oliveira Leal   +5 more
doaj   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

HEV Dynamometer Testing with State-of-Charge Corrections in the 1995 HEV Challenge [PDF]

SAE Technical Paper Series, 1996
<div class="htmlview paragraph">In the 1995 HEV Challenge competition, 17 prototype Hybrid Electric Vehicles (HEVs) were tested by using special HEV test procedures. The contribution of the batteries during the test, as measured by changes in battery state-of-charge (SOC), were accounted for by applying SOC corrections to the test data acquired ...
Duoba, M., Larsen, R.
openaire   +1 more source

Driving Change Together: How Innovative Communication Powers Electrification in the Automotive Industry

Business Strategy and the Environment, EarlyView.
ABSTRACT This paper examines how organizations in the automotive sector respond to the internal communication challenges posed by the transition to electric vehicle production. Unlike typical organizational change, electrification is driven not only by market forces but also by sociopolitical and regulatory pressures to reduce carbon emissions and ...
Tobias Hein, Ruth Woodfield, Jeffrey Hughes   +2 more
wiley   +1 more source

The potential of 48V HEV in real driving [PDF]

, 2016
{"references": ["M. Nalbach, A. K\u00f6rner, C. Hoff, \"Potential and Components of 48V\nLow Cost Hybrid Vehicles\", Intelligent Transport Systems, 10th\nSymposium Hybrid and Electric Vehicles, Braunschweig, 2013.", "T. D\u00f6rsam, S. Kehl, A. Klinkig, A. Radon, O. Sirch, \"Die neue\nSpannungsebene 48V im Kraftfahrzeug\", in ATZelektronik, vol. 7, no.\
Schudeleit, Mark, Sieg, Christian, Küçükay, Ferit   +2 more
openaire   +2 more sources