Results 11 to 20 of about 5,015 (194)

THE EFFECT OF BICYCLOL ON THE STATE OF THE CONNECTIVE TISSUE COMPONENTS OF THE LIVER EXTRACELLULAR MATRIX IN THE COMPLEX THERAPY OF NON-ALCOHOLIC STEATOHEPATITIS WITH LIVER FIBROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Східноукраїнський медичний журнал, 2021
The aim of the research was to determine the probable effect of metformin, rosuvastatin and bicyclol on markers of hepatocyte cytolysis in patients with nonalcoholic steatohepatitis and diabetes mellitus type 2 with diabetic kidney disease, the degree of
Zorіana Ya. Kotsіubiіchuk, Oksana S. Khukhlina, Aliona A. Antonіv, Oleksandra I. Roshchuk, Olga Ye. Mandryk, Oleksandra V. Garvasіuk   +5 more
doaj   +1 more source

Differential response of chondrocytes and chondrogenic-induced mesenchymal stem cells to C1-OH tributanoylated N-acetylhexosamines. [PDF]

PLoS ONE, 2013
Articular cartilage has a limited ability to self-repair because of its avascular nature and the low mitotic activity of the residing chondrocytes. There remains a significant need to develop therapeutic strategies to increase the regenerative capacity ...
Jeannine M Coburn, Nicholas Bernstein, Rahul Bhattacharya, Udayanath Aich, Kevin J Yarema, Jennifer H Elisseeff   +5 more
doaj   +1 more source

Hydrogen-Bonding Network Anchors the Cyclic Form of Sugar Arylhydrazones [PDF]

, 2016
The “classical” challenge, raised by Emil Fischer as to why one monosaccharide arylhydrazone adopts a cyclic structure but another an acyclic structure, is answered here.
Argay, Avalos, Becke, Behrend, Deulofeu, Fischer, Fraser, Gerecs, Hehre, Kövér, Lee, Messmer, Mester, Mester, Mulloy, Pedersen, Stephens, Takeda, Wolfrom, Wolfrom, Zemplén, Zhao, Zhdanov   +22 more
core   +1 more source

New insights into adipocyte-specific leptin gene expression [PDF]

, 2013
The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate adipocyte-specific expression of leptin ...
Rosen, Evan D., Wrann, Christiane D.
core   +1 more source

Synthesis and in vitro cytotoxicity of acetylated 3-fluoro, 4-fluoro and 3,4-difluoro analogs of D-glucosamine and D-galactosamine

Beilstein Journal of Organic Chemistry, 2016
Background: Derivatives of D-glucosamine and D-galactosamine represent an important family of the cell surface glycan components and their fluorinated analogs found use as metabolic inhibitors of complex glycan biosynthesis, or as probes for the study of
Štěpán Horník, Lucie Červenková Šťastná, Petra Cuřínová, Jan Sýkora, Kateřina Káňová, Roman Hrstka, Ivana Císařová, Martin Dračínský, Jindřich Karban   +8 more
doaj   +1 more source

A single site in human β-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside [PDF]

, 2003
Human β-hexosaminidase A (Hex A) (αβ) is composed of two subunits whose primary structures are ∼60% identical. Deficiency of either subunit results in severe neurological disease due to the storage of GM2 ganglioside; Tay–Sachs disease, α deficiency, and
Abbink, E.J., Beulens, J.W., Dekker, J.M., Dekkers, O.M., DeVries, J.H., Diabet Pearl Parelsnoer Initiative, Elders, P.J.M., Holleman, F., Nijpels, G., Ozcan, B., Pijl, H., Rauh, S.P., Rutte, A., Rutters, F., Schaper, N.C., Schram, M.T., Sijbrands, E.J.G., Silvius, B., Stehouwer, C.D.A., Tack, C.J., Valk, H.W. de, Wolffenbuttel, B.H.R.   +21 more
core   +12 more sources

Bioquímica e ação citotóxica de alfa-aminocetonas endógenas Biochemistry and cytotoxicity of alpha-aminoketones

Química Nova, 2005
alpha-Aminoketones are expected to undergo enolization and subsequent aerobic oxidation yielding oxyradicals and highly toxic a-oxoaldehydes. Our interest has been focused on two endogenous a-aminoketones: 5-aminolevulinic acid (ALA) and aminoacetone (AA)
Fernando Dutra, Etelvino J. H. Bechara
doaj   +1 more source

Effect of Antiepileptic Drug Sodium Valproate on Stomach Tissue Glycoproteins: The Protective Role of Moringa Extract

Archives of Epilepsy, 2023
Objective:Sialic acid, hexoses, hexosamines and fucose are components of glycoprotein, glycolipid and/or ganglioside. These glycoconjugates are essential components of cellular membrane and receptors, which are required for normal cellular activities ...
Umar Faruk Magaji, Syhejla Miftari, Özlem Saçan, Refiye Yanardağ   +3 more
doaj   +1 more source

Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source. [PDF]

PLoS Pathogens, 2010
Intracellular parasites, such as Leishmania spp, must acquire suitable carbon sources from the host cell in order to replicate. Here we present evidence that intracellular amastigote stages of Leishmania exploit amino sugars in the phagolysosome of ...
Thomas Naderer, Joanne Heng, Malcolm J McConville   +2 more
doaj   +1 more source

Cytotoxicity and Glycan-Binding Properties of an 18 kDa Lectin Isolated from the Marine Sponge <em>Halichondria </em><em>o</em><em>kadai</em>

Toxins, 2012
A divalent cation-independent lectin—HOL-18, with cytotoxic activity against leukemia cells, was purified from a demosponge, <em>Halichondria okadai</em>. HOL-18 is a 72 kDa tetrameric lectin that consists of four non-covalently bonded 18 kDa
Yasuhiro Ozeki, Jiharu Hamako, Taei Matsui, Kazuo Nitta, Masahiro Hosono, Shigeki Sugawara, Chang Hun Im, Yukiko Ogawa, Hidetaro Yasumitsu, Robert A. Kanaly, Sarkar M. A. Kawsar, Yuki Fujii, Ryo Matsumoto, Chihiro Iwahara, Imtiaj Hasan, Yasuhiro Koide   +15 more
doaj   +1 more source