Results 11 to 20 of about 5,058 (210)
Differential response of chondrocytes and chondrogenic-induced mesenchymal stem cells to C1-OH tributanoylated N-acetylhexosamines. [PDF]
PLoS ONE, 2013 Articular cartilage has a limited ability to self-repair because of its avascular nature and the low mitotic activity of the residing chondrocytes. There remains a significant need to develop therapeutic strategies to increase the regenerative capacity ...
Jeannine M Coburn +5 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2016 Background: Derivatives of D-glucosamine and D-galactosamine represent an important family of the cell surface glycan components and their fluorinated analogs found use as metabolic inhibitors of complex glycan biosynthesis, or as probes for the study of
Štěpán Horník +8 more
doaj +1 more source
IR ion spectroscopy in a combined approach with MS/MS and IM-MS to discriminate epimeric anthocyanin glycosides (cyanidin 3-O-glucoside and -galactoside) [PDF]
, 2019 Anthocyanins are widespread in plants and flowers, being responsible for their different colouring. Two representative members of this family have been selected, cyanidin 3-O-β-glucopyranoside and 3-O-β-galactopyranoside, and probed by mass spectrometry ...
Botta, B. +10 more
core +3 more sources
Química Nova, 2005 alpha-Aminoketones are expected to undergo enolization and subsequent aerobic oxidation yielding oxyradicals and highly toxic a-oxoaldehydes. Our interest has been focused on two endogenous a-aminoketones: 5-aminolevulinic acid (ALA) and aminoacetone (AA)
Fernando Dutra, Etelvino J. H. Bechara
doaj +1 more source
New insights into adipocyte-specific leptin gene expression [PDF]
, 2013 The adipocyte-derived hormone leptin is a critical regulator of many physiological functions, ranging from satiety to immunity. Surprisingly, very little is known about the transcriptional pathways that regulate adipocyte-specific expression of leptin ...
Rosen, Evan D., Wrann, Christiane D.
core +1 more source
Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells [PDF]
, 2010 AIMS/HYPOTHESIS: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of endoplasmic reticulum (ER) stress in the induction of insulin resistance by glucosamine in ...
Andreozzi, F +12 more
core +1 more source
Archives of Epilepsy, 2023 Objective:Sialic acid, hexoses, hexosamines and fucose are components of glycoprotein, glycolipid and/or ganglioside. These glycoconjugates are essential components of cellular membrane and receptors, which are required for normal cellular activities ...
Umar Faruk Magaji +3 more
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A single site in human β-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside [PDF]
, 2003 Human β-hexosaminidase A (Hex A) (αβ) is composed of two subunits whose primary structures are ∼60% identical. Deficiency of either subunit results in severe neurological disease due to the storage of GM2 ganglioside; Tay–Sachs disease, α deficiency, and
Abbink, E.J. +21 more
core +13 more sources
Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source. [PDF]
PLoS Pathogens, 2010 Intracellular parasites, such as Leishmania spp, must acquire suitable carbon sources from the host cell in order to replicate. Here we present evidence that intracellular amastigote stages of Leishmania exploit amino sugars in the phagolysosome of ...
Thomas Naderer +2 more
doaj +1 more source
Toxins, 2012 A divalent cation-independent lectin—HOL-18, with cytotoxic activity against leukemia cells, was purified from a demosponge, <em>Halichondria okadai</em>. HOL-18 is a 72 kDa tetrameric lectin that consists of four non-covalently bonded 18 kDa
Yasuhiro Ozeki +15 more
doaj +1 more source