Results 61 to 70 of about 2,313 (194)

Activity‐Informed Network Analysis Reveals Keystone Microbes Shaping Freshwater Ecosystem Function

Environmental Microbiology Reports, Volume 18, Issue 2, April 2026.
Graphical abstract illustrating the workflow and key findings of this study. We first applied SPIEC‐EASI to metagenomic abundance data to construct microbial co‐occurrence networks and selected the top 15 MAGs based on degree centrality. We then used CARlasso to detect relationships between the top MAGs and environmental features.
Qiyao Yang, Rosa Aghdam, Patricia Q. Tran, Karthik Anantharaman, Claudia Solís‐Lemus   +4 more
wiley   +1 more source

Major Cat Allergen Fel d 4: Structure and Identification of a Cross‐Reactive IgE‐Epitope‐Containing Area

Allergy, Volume 81, Issue 4, Page 1075-1088, April 2026.
This study reports the three‐dimensional structure of an important cat allergen, Fel d 4, that shares high homology with Equ c 1 (i.e., major horse allergen) and Can f 6 (i.e., dog allergen). The C‐terminal region of the Fel d 4 contains a major IgE‐reactive epitope.
Nikolina Todorović, Daria Trifonova, Zicheng Liu, Mirela Curin, Laszlo Schooltink, Theo Sagmeister, Christoph Grininger, Renata Kiss, Nina Gottstein, Bernd Gesslbauer, Andreas Winkler, Tea Pavkov‐Keller, Alexander Karaulov, Rudolf Valenta, Walter Keller   +14 more
wiley   +1 more source

Familial X-linked cardiomyopathy (Danon disease): diagnostic confirmation by mutation analysis of the LAMP2 gene [PDF]

, 2018
A boy presented at age 2.5 years with mild left ventricular hypertrophy and mild myopathy. Hypertrophic cardiomyopathy progressed relentlessly, leading to death at age 16 years shortly before planned heart transplantation.
Ballhausen, Diana, Balmer, Christian, Bauersfeld, Urs, Boltshauser, Eugen, Bosshard, Nils, Steinmann, Beat, Superti-Furga, Andrea   +6 more
core  

The Dietary Polyphenol Resveratrol in Intestinal Ischemia–Reperfusion Injury: From Multifaceted Protective Mechanisms to Clinical Translation Challenges

Food Science &Nutrition, Volume 14, Issue 3, March 2026.
Intestinal ischemia–reperfusion (I/R) injury is a life‐threatening condition with mortality approaching 50%, driven by oxidative stress, inflammatory cascades, ferroptosis, and intestinal barrier disruption that ultimately precipitates distant organ dysfunction.
Xue‐feng Zhang, Zhi Huang, Yuan Zeng, Yan Zhang, Ping Li, Fei‐xiang Wang, Liang Nie   +6 more
wiley   +1 more source

Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Mast cells drive early allergic asthma by releasing histamine, interleukins and prostaglandins, causing airway hyperresponsiveness, mucus overproduction and inflammation. These events sustain symptoms and promote structural remodelling, contributing to the progression of the disease.
Iêda Maria dos Santos, João Lázaro de Oliveira Rocha, Edilson Beserra de Alencar Filho, Fabrício Souza Silva   +3 more
wiley   +1 more source

GM2-Gangliosidosis (Sandhoff and Tay Sachs disease): Diagnosis and Neuroimaging Findings (An Iranian Pediatric Case Series) [PDF]

, 2014
How to Cite This Article: Karimzadeh P, Jafari N, Nejad Biglari H, Jabbeh Dari S, Ahmad Abadi F, Alaee MR, Nemati H, Saket S,Tonekaboni SH, Taghdiri MM, Ghofrani M. GM2-Gangliosidosis (Sandhoff and Tay Sachs disease): Diagnosis and Neuroimaging Findings (
AHMAD ABADI, Farzad, ALAEE, Mohammad-Reza, GHOFRANI, Mohammad, JABBEH DARI, Sayena, JAFARI, Narjes, KARIMZADEH, Parvaneh, NEJAD BIGLARI, Habibeh, NEMATI, Hamid, SAKET, Sasan, TAGHDIRI, Mohammad-Mahdi, TONEKABONI, Seyed Hassan   +10 more
core   +2 more sources

Calcium Dysregulation Promotes Glioma Progression by Inhibiting STAT3 Degradation Through Blocking Chaperone‐Mediated Autophagy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Calcium dysregulation is closely associated with cancer cell proliferation, migration, and invasion. Transient receptor potential canonical 1 (TRPC1) plays an essential role in regulating calcium homeostasis. However, the role of TRPC1 in calcium dysregulation in gliomas remains incompletely understood. In this study, we demonstrate that TRPC1
Jialong Chen, Yixi Lai, Mingque Li, ZiWei Cai, Renjian Lu, Linhua Liu, Yongming Peng, Chunlai Fu, Zhefan Xie, Xueqion Zhou, Jiaxian Liu, He Zhang   +11 more
wiley   +1 more source

Longitudinal metabolomics study of phosphate‐adenine‐guanosine‐glucose‐saline‐mannitol stored red blood cells

Transfusion, Volume 66, Issue 3, Page 455-467, March 2026.
Abstract Background The storage of red blood cells (RBCs) is essential for transfusion but leads to storage lesions that compromise RBC quality and increase the risk of transfusion‐related adverse effects, including allergic transfusion reactions (ATRs). Understanding storage‐induced metabolic change is crucial for enhancing transfusion safety.
Gürkan Bal, Maia Dzamashvili, Zhuoran Li, Magda Babina, Nidal Toman, Abdulgabar Salama   +5 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, Volume 600, Issue 4, Page 504-514, February 2026.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors [PDF]

, 2015
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. A stereoselective synthesis of 2-
Farrar-Tobar, Ronald A., Fuente, Alex de la, García Fernández, José Manuel, Mena Barragán, Teresa, Ortiz Mellet, Carmen, Riera, Antoni, Verdaguer, Xavier   +6 more
core   +3 more sources