Results 51 to 60 of about 2,313 (194)

The subunits of human hexosaminidase A [PDF]

Biochemical Journal, 1976
Previous studies of the subunit structure of hexosaminidase gave ambiguous results, but suggested that the enzyme was composed of six equally sized subunits. Dissociation of hexosaminidase A with p-chloromercuribenzoate produces an alkylated fragment with mol.wt. approx.
E, Beutler, A, Yoshida, W, Kuhl, J E, Lee   +3 more
openaire   +2 more sources

Solvent‐Dependent Biological Activities of Aqueous and Ethanolic Extracts From Edible Insect Larvae

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This study compares the functional activity profiles of aqueous and ethanolic extracts from edible insect larvae. Solvent‐dependent extraction resulted in distinct bioactivity patterns, highlighting the importance of extraction conditions in determining the functional potential of insect‐derived bioactive compounds.
Min‐Cheol Kang, Seung Tae Im, Tae‐Kyung Kim, Min Kyung Park, Hae In Yong, Ginnae Ahn, Eui Jeong Han, Ji‐Yoon Cha, Kyung‐Mo Song, Yun‐Sang Choi   +9 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Peptide‐Incorporated Biomaterials Promote Regeneration of Peripheral Nerve Injuries

Advanced Science, Volume 13, Issue 23, 23 April 2026.
Peptide‐incorporated biomaterials provide precise, tunable biological cues that mimic functional protein domains to regulate behaviors of neurons, Schwann cells, immune cells, and endothelial cells, thereby enhancing axon elongation, Schwann cell support, inflammatory microenvironment modulation, and vascularization, offering a promising alternative to
Zhiwei Zhao, Jianfeng Liu, Jincheng Li, Di Li, Jianxun Ding, Bin Liu   +5 more
wiley   +1 more source

Contribution of shape and charge to the inhibition of a family GH99 endo-α-1,2-mannanase [PDF]

, 2017
[Image: see text] Inhibitor design incorporating features of the reaction coordinate and transition-state structure has emerged as a powerful approach for the development of enzyme inhibitors.
Davies, Gideon John, Fernandes, Pearl Z., Ganeko, Bernardo-Seisdedos, Jiménez-Barbero, Jesús, Millet, Oscar, Petricevic, Marija, Raich, Lluís, Rovira, Carme, Sobala, Lukasz, Sollogoub, Matthieu, Thompson, Andrew James, Williams, Spencer J., Zhu, Sha   +12 more
core   +4 more sources

Diagnostic performance of salivary markers of Alzheimer's disease: A systematic review

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract High heterogeneity of diagnostic accuracy have been reported for salivary markers of Alzheimer's disease (AD), but the reasons remain unclear. This systematic review aims to evaluate the potential sources of heterogeneity in the diagnostic performance of salivary biomarkers for the identification of AD.
Priscilla Vendramini Borelli, Leonardo Machado, Giovanna Carello‐Collar, Pamela C. L. Ferreira, Amanda Muliterno Domingues Lourenço de Lima, Bruna Bellaver, Tharick Ali Pascoal, Andrea L. Benedet, Nicholas J. Ashton, Eduardo R Zimmer, Wyllians Vendramini Borelli   +10 more
wiley   +1 more source

Isoenzymes of N-acetyl-beta-hexosaminidase.

Acta Biochimica Polonica, 1999
Biological significance, structure and posttranslational processing of N-acetyl-beta-hexosaminidase isoenzymes are described. Clinical application of N-acetyl-beta-hexosaminidase is also reviewed.
K, Zwierz, A, Zalewska, A, Zoch-Zwierz
openaire   +3 more sources

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy [PDF]

, 2016
Sustained glucose and glutamine transport are essential for activated T lymphocytes to support ATP and macromolecule biosynthesis. We now show that glutamine and glucose also fuel an indispensible dynamic regulation of intracellular protein O ...
A Boudil, A Golks, A Suzuki, A Wolfer, AJ Marko, AL Doedens, AN Macintyre, AP Kelly, C-H Chang, C-Y Huang, Daan M F van Aalten, DC Turnock, DK Finlay, Doreen A Cantrell, EL Carr, EL Pearce, FV Rao, G Balciunaite, GC Preston, GW Hart, GW Hart, HC Dorfmueller, HJ Hinton, J Rolf, J Zhang, J Zhong, Katarzyna M Grzes, KP Kearse, Linda V Sinclair, LJ Beverly, LV Sinclair, M Ciofani, M Ciofani, M Dose, M Dose, M Nakaya, Mahima Swamy, MP Mycko, MR Bond, N O'Donnell, NJ MacIver, P Ramakrishnan, P-C Ho, R Shafi, R Wang, Sebastian Damerow, Shalini Pathak, TJ Hagenbeek, TJ Hagenbeek, TM Gloster, TM Schmitt, TY Chou, U Koch, W Liao, Z Wang   +54 more
core   +3 more sources

Sequence‐Based and Functional Analysis for the Discovery of N‐Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This research offers valuable understanding of how N‐glycans are broken down by the gut microbiota of infants, focusing on glycoside hydrolase families GH2, GH20, and GH18. It reveals that the gut microbiota of breastfed infants has a diverse array of genes coding for these enzymes.
Irene Boscá‐Sánchez, Jesús Rodríguez‐Díaz, María J. Yebra   +2 more
wiley   +1 more source

Ruthenibacterium lactatiformans gen. nov., sp.nov., an anaerobic, lactate-producing member of the family Ruminococcaceae isolated from human faeces [PDF]

, 2016
Two novel strains of Gram-stain-negative, rod-shaped, obligately anaerobic, non-spore-forming, non-motile bacteria were isolated from the faeces of healthy human subjects.
Bozhenko, Vladimir K., Chaplin, Andrei V., Efimov, Boris A., Kafarskaia, Lyudmila I., Shcherbakova, Victoria A., Shkoporov, Andrei N., Suzina, Natalia E.   +6 more
core   +1 more source