Results 31 to 40 of about 2,313 (194)

Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives

Molecules, 2014
NAG-thiazoline is a strong competitive inhibitor of GH20 β-N-acetyl- hexosaminidases and GH84 β-N-acetylglucosaminidases. Here, we focused on the design, synthesis and inhibition potency of a series of new derivatives of NAG-thiazoline modified at the C ...
Jana Krejzová, Petr Šimon, Lubica Kalachova, Natallia Kulik, Pavla Bojarová, Petr Marhol, Helena Pelantová, Josef Cvačka, Rüdiger Ettrich, Kristýna Slámová, Vladimír Křen   +10 more
doaj   +1 more source

Agaricus bisporus Crude Extract: Characterization and Analytical Application

Molecules, 2020
In the present work crude Agaricus bisporus extract (ABE) has been prepared and characterized by its tyrosinase activity, protein composition and substrate specificity.
Maria A. Morosanova, Tatyana V. Fedorova, Alexandra S. Polyakova, Elena I. Morosanova   +3 more
doaj   +1 more source

Mechanism of Human Nucleocytoplasmic Hexosaminidase D [PDF]

Biochemistry, 2016
Mammalian β-hexosaminidases have been shown to play essential roles in cellular physiology and health. These enzymes are responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates.
Alteen, Matthew G, Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B H, Vacadlo, David J, Gloster, Tracey Maureen   +5 more
openaire   +4 more sources

A Novel Hyaluronidase from Brown Spider (Loxosceles intermedia) Venom (Dietrich's Hyaluronidase): From Cloning to Functional Characterization [PDF]

, 2013
Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. the venom contains several enzymatic toxins.
Chaim, Olga Meiri, Ferrer, Valeria Pereira, Gremski, Luiza Helena, Gremski, Waldemiro, Mari, Thiago Lopes de, Nader, Helena Bonciani, Senff-Ribeiro, Andrea, Silva, Dilza Trevisan, Silveira, Rafael Bertoni da, Veiga, Silvio Sanches   +9 more
core   +4 more sources

Interaction between human mucins and parasite glycoproteins: the role of lectins and glycosidases in colonization by intestinal protozoa

Revista do Instituto de Medicina Tropical de São Paulo, 2020
Intestinal mucins are the first line of defense against microorganisms. Although knowledge about the mechanisms involved in the establishment of intestinal protozoa is limited, there is evidence that these parasites produce lectin-like molecules and ...
Joel Martínez-Ocaña, Pablo Maravilla, Angélica Olivo-Díaz   +2 more
doaj   +1 more source

Glycosidases during chick embryo lung development and their colocalization with proteoglycans and growth factors

European Journal of Histochemistry, 2009
During development, the epithelial component of the lung goes through a complex orderly process of branching, following strict patterns of space and time.
G Stabellini, M Calvitti, T Baroni, L Marinucci, C Calastrini, P Carinci, E Becchetti   +6 more
doaj   +1 more source

Bifidobacterium mongoliense genome seems particularly adapted to milk oligosaccharide digestion leading to production of antivirulent metabolites

BMC Microbiology, 2020
Background Human milk oligosaccharides (HMO) could promote the growth of bifidobacteria, improving young children’s health. In addition, fermentation of carbohydrates by bifidobacteria can result in the production of metabolites presenting an ...
Pauline Bondue, Christian Milani, Emilie Arnould, Marco Ventura, Georges Daube, Gisèle LaPointe, Véronique Delcenserie   +6 more
doaj   +1 more source

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of β-N-acetylglucosaminidases [PDF]

, 2007
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of β-N-acetylglucosaminidases are described.
Adrian Scaffidi, Backvall, Bailey, Beer, Chen, Chretien, David J. Vocadlo, Davies, Davies, Dennis, Dong, Dorfmueller, Edward J. Taylor, Emsley, Esnouf, Fairweather, Gideon J. Davies, Horsch, Junge, Kappes, Keith A. Stubbs, Knapp, Kraulis, Legler, Lin, Liu, Liu, Macauley, Mark, Money, Murshudov, Namiki, Nicotra, Ogawa, Rana, Rao, Rebecca J. Dennis, Robert V. Stick, Salleh, Scaffidi, Shanmugasundaram, Shitara, Sigurskjold, Stubbs, Stubbs, Svensson, Tanaka, Terinek, Tews, Vocadlo   +49 more
core   +1 more source

Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation [PDF]

, 2016
Bacteroides vulgatus is a member of the human microbiota whose abundance is increased in patients with Crohn's disease. We show that a B. vulgatus glycoside hydrolase from the carbohydrate active enzyme family GH123, BvGH123, is an N-acetyl-β ...
A. John, Abbott, Bojanova, Bäckhed, C. Roth, Cekic, Copley, Darby, Dennis, Drouillard, E. D. Goddard-Borger, Falk, G. J. Davies, Goldman, He, Hemsworth, Knapp, Korczynska, Krissinel, Lai, Larsbrink, Larsbrink, M. Petricevic, Macauley, Macdonald, Mark, Noach, Pudlo, Robb, Ruseler-van Embden, S. J. Williams, Sumida, Sumida, Terrapon, Vocadlo, White, Whitworth, Williams   +37 more
core   +1 more source

Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease

Journal of Lipid Research, 2017
Drug-induced phospholipidosis (DIPL) is characterized by an increase in the phospholipid content of the cell and the accumulation of drugs and lipids inside the lysosomes of affected tissues, including in the liver.
Emmanuelle Lecommandeur, David Baker, Timothy M. Cox, Andrew W. Nicholls, Julian L. Griffin   +4 more
doaj   +1 more source