Results 31 to 40 of about 7,764 (216)

Enzymatic properties and subtle differences in the substrate specificity of phylogenetically distinct invertebrate N-glycan processing hexosaminidases

Glycobiology, 2014
Fused lobes (FDL) hexosaminidases are the most recently genetically defined glycosidases involved in the biosynthesis of N-glycans in invertebrates, and their narrow specificity is essential for the generation of paucimannosidic N-glycans in insects.
Martin Dragosits, Shi Yan, E. Razzazi-Fazeli, I. Wilson, D. Rendić   +4 more
semanticscholar   +1 more source

Interaction between human mucins and parasite glycoproteins: the role of lectins and glycosidases in colonization by intestinal protozoa

Revista do Instituto de Medicina Tropical de São Paulo, 2020
Intestinal mucins are the first line of defense against microorganisms. Although knowledge about the mechanisms involved in the establishment of intestinal protozoa is limited, there is evidence that these parasites produce lectin-like molecules and ...
Joel Martínez-Ocaña, Pablo Maravilla, Angélica Olivo-Díaz   +2 more
doaj   +1 more source

Glycosidases during chick embryo lung development and their colocalization with proteoglycans and growth factors

European Journal of Histochemistry, 2009
During development, the epithelial component of the lung goes through a complex orderly process of branching, following strict patterns of space and time.
G Stabellini, M Calvitti, T Baroni, L Marinucci, C Calastrini, P Carinci, E Becchetti   +6 more
doaj   +1 more source

Bifidobacterium mongoliense genome seems particularly adapted to milk oligosaccharide digestion leading to production of antivirulent metabolites

BMC Microbiology, 2020
Background Human milk oligosaccharides (HMO) could promote the growth of bifidobacteria, improving young children’s health. In addition, fermentation of carbohydrates by bifidobacteria can result in the production of metabolites presenting an ...
Pauline Bondue, Christian Milani, Emilie Arnould, Marco Ventura, Georges Daube, Gisèle LaPointe, Véronique Delcenserie   +6 more
doaj   +1 more source

Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors [PDF]

, 2016
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. A stereoselective synthesis of 2-
Fuente Cebrián, Àlex de la, Riera i Escalé, Antoni, Mena-Barragán, Teresa, Farrar-Tobar, Ronald A., García-Fernández, J. M., Verdaguer i Espaulella, Xavier, Ortiz Mellet, Carmen   +6 more
core   +3 more sources

Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease

Journal of Lipid Research, 2017
Drug-induced phospholipidosis (DIPL) is characterized by an increase in the phospholipid content of the cell and the accumulation of drugs and lipids inside the lysosomes of affected tissues, including in the liver.
Emmanuelle Lecommandeur, David Baker, Timothy M. Cox, Andrew W. Nicholls, Julian L. Griffin   +4 more
doaj   +1 more source

Homozygous variants in the HEXB and MBOAT7 genes underlie neurological diseases in consanguineous families

BMC Medical Genetics, 2019
Background Neurological disorders are a common cause of morbidity and mortality within Pakistani populations. It is one of the most important challenges in healthcare, with significant life-long socio-economic burden. Methods We investigated the cause of
Shazia Khan, Lettie E. Rawlins, Gaurav V. Harlalka, Muhammad Umair, Asmat Ullah, Shaheen Shahzad, Muhammad Javed, Emma L. Baple, Andrew H. Crosby, Wasim Ahmad, Asma Gul   +10 more
doaj   +1 more source

Mechanism of Human Nucleocytoplasmic Hexosaminidase D [PDF]

Biochemistry, 2016
Mammalian β-hexosaminidases have been shown to play essential roles in cellular physiology and health. These enzymes are responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates.
Alteen, Matthew G, Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B H, Vacadlo, David J, Gloster, Tracey Maureen   +5 more
openaire   +4 more sources

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source